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Critical Care
Published in: Critical Care 5/2012

01-10-2012 | Review

Clinical review: Biomarkers of acute kidney injury: where are we now?

Authors: Marlies Ostermann, Barbara J Philips, Lui G Forni

Published in: Critical Care | Issue 5/2012

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Abstract

The recognition that acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality has resulted in a substantial number of publications over the past 5 years or more. In no small part these have, to a degree, highlighted the inadequacy of conventional markers of renal insufficiency in the acute setting. Much effort has been invested in the identification of early, specific AKI markers in order to aid early diagnosis of AKI and hopefully improve outcome. The search for a 'biomarker' of AKI has seen early promise replaced by a degree of pessimism due to the lack of a clear candidate molecule and variability of results. We outline the major studies described to date as well as discuss potential reasons for the discrepancies observed and suggest that evolution of the field may result in success with ultimately an improvement in patient outcomes.
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Metadata
Title
Clinical review: Biomarkers of acute kidney injury: where are we now?
Authors
Marlies Ostermann
Barbara J Philips
Lui G Forni
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11380

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