Published in:
01-08-2013 | Nephrology - Original Paper
High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
Authors:
Tanja Antunovic, Aleksandra Stefanovic, Marina Ratkovic, Branka Gledovic, Najdana Gligorovic-Barhanovic, Dragica Bozovic, Jasmina Ivanisevic, Milica Prostran, Marina Stojanov
Published in:
International Urology and Nephrology
|
Issue 4/2013
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Abstract
Purpose
We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.
Methods
SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.
Results
sUA among survivors (112.1 ± 13.82 μmol/L) was significantly lower than in deceased (160.8 ± 16.81 μmol/L, p < 0.001), while SOD was higher in survivors (31.8 ± 6.61 kU/L) than among deceased (20.2 ± 3.03, p < 0.05). Kaplan–Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (≥127.11 μmol/L, p < 0.001), and for SOD in the lowest tertile (≤23.83 kU/L, p < 0.05).
Conclusion
Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.