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International Urology and Nephrology
Published in: International Urology and Nephrology 1/2012

01-02-2012 | Nephrology – Original Paper

Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients

Authors: Erhan Tatar, Meltem Sezis Demirci, Fatih Kircelli, Ozkan Gungor, Mehmet Nuri Turan, Ebru Sevinc Ok, Gulay Asci, Mehmet Ozkahya, Ercan Ok

Published in: International Urology and Nephrology | Issue 1/2012

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Abstract

Background

Insulin resistance is a risk factor for cardiovascular morbidity and mortality in the general and end-stage renal disease populations. In this study, we investigated the association between insulin resistance and arterial stiffness in nondiabetic peritoneal dialysis (PD) patients.

Methods

Fifty-three patients were enrolled. Patients were divided into 2 groups as homeostasis model assessment of insulin resistance (HOMA-IR) ≤2.97 (low) and >2.97 (high). Carotid–femoral pulse wave velocity (c-f PWV) analysis and intima-media thickness of the carotid artery were measured.

Results

Mean age was 46 ± 12 years and HOMA-IR was 2.97 ± 1.77 (0.77–8.88). Mean c-f PWV was 7.6 ± 1.7 m/s. HOMA-IR was positively correlated with age, body mass index, and c-f PWV and negatively with serum HDL cholesterol and parathormone. In linear regression analysis, age and mean arterial pressure were predictors for c-f PWV. When patients were divided into 2 groups according to median age as ≤49 and >50, mean arterial pressure, male gender, and age were predictors for c-f PWV in patients aged ≤49, whereas HOMA-IR was the only predictor for c-f PWV in patients aged >50 years.

Conclusion

Insulin resistance is an independent risk factor for arterial stiffness in PD patients older than 50 years. IR is not associated with carotid intima-media thickness.
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Metadata
Title
Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients
Authors
Erhan Tatar
Meltem Sezis Demirci
Fatih Kircelli
Ozkan Gungor
Mehmet Nuri Turan
Ebru Sevinc Ok
Gulay Asci
Mehmet Ozkahya
Ercan Ok
Publication date
01-02-2012
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 1/2012
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-011-9984-z

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