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International Urology and Nephrology
Published in: International Urology and Nephrology 3/2012

01-06-2012 | Urology - Original Paper

The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study

Author: Mohammad Reza Safarinejad

Published in: International Urology and Nephrology | Issue 3/2012

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Abstract

Objective

It has been shown that coenzyme Q10 (CoQ10) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ10 supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT.

Patients and methods

Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ10 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ10 discontinuation.

Results

Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ10 therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.

Conclusions

CoQ10 supplementation improves semen quality with beneficial effect on pregnancy rate.
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Metadata
Title
The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study
Author
Mohammad Reza Safarinejad
Publication date
01-06-2012
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 3/2012
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-011-0081-0

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