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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 3/2014

01-09-2014

Cardiovascular and hemodynamic effects of glucagon-like peptide-1

Authors: Adam G. Goodwill, Kieren J. Mather, Abass M. Conteh, Daniel J. Sassoon, Jillian N. Noblet, Johnathan D. Tune

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 3/2014

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Abstract

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has been shown to have hemodynamic and cardioprotective capacity in addition to its better characterized glucoregulatory actions. Because of this, emerging research has focused on the ability of GLP-1 based therapies to drive myocardial substrate selection, enhance cardiac performance and regulate heart rate, blood pressure and vascular tone. These studies have produced consistent and reproducible results amongst numerous laboratories. However, there are obvious disparities in findings obtained in small animal models versus those of higher mammals. This species dependent discrepancy calls to question, the translational value of individual findings. Moreover, few studies of GLP-1 mediated cardiovascular action have been performed in the presence of a pre-existing comorbidities (e.g. obesity/diabetes) which limits interpretation of the effectiveness of incretin-based therapies in the setting of disease. This review addresses cardiovascular and hemodynamic potential of GLP-1 based therapies with attention to species specific effects as well as the interaction between therapies and disease.
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Metadata
Title
Cardiovascular and hemodynamic effects of glucagon-like peptide-1
Authors
Adam G. Goodwill
Kieren J. Mather
Abass M. Conteh
Daniel J. Sassoon
Jillian N. Noblet
Johnathan D. Tune
Publication date
01-09-2014
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 3/2014
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-014-9290-z

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