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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 1/2012

01-03-2012

Relevance of vitamin D in muscle health

Author: Heike A. Bischoff-Ferrari

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 1/2012

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Abstract

This review will summarize the impact of vitamin D deficiency on muscle health. Mechanistic evidence regarding the presence of the specific vitamin D receptor in muscle tissue and muscle biopsy abnormalities observed with deficiency will be reviewed, as well as molecular and non-molecular effects of vitamin D in muscle tissue. At the clinical level, the evidence from randomized controlled trials of vitamin D supplementation on functional improvement and fall reduction will be summarized. Further, the manuscript will discuss whether vitamin D effects on fall prevention modulate in part its benefit on fracture prevention and why fall prevention is essential in fracture prevention at higher age. Finally, trial and epidemiological data will be reviewed to assess desirable serum 25-hydroxyvitamin D levels for optimal muscle health.
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Metadata
Title
Relevance of vitamin D in muscle health
Author
Heike A. Bischoff-Ferrari
Publication date
01-03-2012
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 1/2012
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-011-9200-6

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