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Published in: Reviews in Endocrine and Metabolic Disorders 3/2006

01-09-2006

The renaissance of insulin pump treatment in childhood type 1 diabetes

Authors: William V. Tamborlane, Karena Swan, Kristin A. Sikes, Amy T. Steffen, Stuart A Weinzimer

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 3/2006

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Abstract

Current goals for the treatment of children and adolescents with type 1 diabetes mellitus include achieving near-normal blood sugar levels, minimizing the risk of hypoglycemia, optimizing quality of life, and preventing or delaying long-term microvascular and macrovascular complications. Continuous subcutaneous insulin infusion (CSII), or insulin pump therapy, provides a treatment option that can assist in the attainment of all of these goals in all ages of children. In pediatric patients, CSII has been demonstrated to reduce both glycosylated hemoglobin levels and frequency of severe hypoglycemia, without sacrifices in safety, quality of life, or weight gain, particularly in conjunction with the use of new insulin analogs and improvements in pump technology. Clinical studies of safety and efficacy of CSII in children are reviewed, as well as criteria for patient selection and practical considerations using pump therapy in youth with T1DM.
Literature
1.
go back to reference Tamborlane WV, Sherwin RS, Genel M, Felig P. Reduction to normal of plasma glucose in juvenile diabetics by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med 1979;300 11:573–8.PubMedCrossRef Tamborlane WV, Sherwin RS, Genel M, Felig P. Reduction to normal of plasma glucose in juvenile diabetics by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med 1979;300 11:573–8.PubMedCrossRef
2.
go back to reference Pickup JC, Keen H, Parsons JA, Alberti KG. Continuous subcutaneous insulin infusion: an approach to achieving normoglycemia. Br Med J 1978;1 6107:204–7.PubMedCrossRef Pickup JC, Keen H, Parsons JA, Alberti KG. Continuous subcutaneous insulin infusion: an approach to achieving normoglycemia. Br Med J 1978;1 6107:204–7.PubMedCrossRef
3.
go back to reference Lauritzen T, Pramming S, Deckert T, Binder C. Pharmacokinetics of continuous subcutaneous insulin infusion. Diabetologia 1983;24 5:326–9.PubMedCrossRef Lauritzen T, Pramming S, Deckert T, Binder C. Pharmacokinetics of continuous subcutaneous insulin infusion. Diabetologia 1983;24 5:326–9.PubMedCrossRef
4.
go back to reference Tamborlane WV, Sherwin RS, Genel M, Felig P. Outpatient management of juvenile-onset diabetics with a portable subcutaneous insulin infusion pump. Am J Med 1980;68:190–6.PubMedCrossRef Tamborlane WV, Sherwin RS, Genel M, Felig P. Outpatient management of juvenile-onset diabetics with a portable subcutaneous insulin infusion pump. Am J Med 1980;68:190–6.PubMedCrossRef
5.
go back to reference DCCT Research Group. Resource utilization and costs of care in the Diabetes Control and Complications Trial. Diabetes Care 1995;18 11:1468–78.CrossRef DCCT Research Group. Resource utilization and costs of care in the Diabetes Control and Complications Trial. Diabetes Care 1995;18 11:1468–78.CrossRef
6.
go back to reference Amiel SA, Tamborlane WV, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin dependent diabetes mellitus. N Engl J Med 1987;316:1376–83.PubMedCrossRef Amiel SA, Tamborlane WV, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin dependent diabetes mellitus. N Engl J Med 1987;316:1376–83.PubMedCrossRef
7.
go back to reference Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988;37:901–7.PubMedCrossRef Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988;37:901–7.PubMedCrossRef
8.
go back to reference Cryer PE. Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM: a vicious cycle. Diabetes 1992;41:255–60.PubMedCrossRef Cryer PE. Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM: a vicious cycle. Diabetes 1992;41:255–60.PubMedCrossRef
9.
go back to reference DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The diabetes control and complications trial. N Engl J Med 1993;329 14:977–86.CrossRef DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The diabetes control and complications trial. N Engl J Med 1993;329 14:977–86.CrossRef
10.
go back to reference The DCCT Research Group. The effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: the diabetes control and complications trial. J Pediatr 1994;125 2:177–88.CrossRef The DCCT Research Group. The effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: the diabetes control and complications trial. J Pediatr 1994;125 2:177–88.CrossRef
11.
go back to reference DCCT/EDIC Research Group. Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the diabetes control and complications trial. J Pediatr 2001;139 6:804–12.CrossRef DCCT/EDIC Research Group. Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the diabetes control and complications trial. J Pediatr 2001;139 6:804–12.CrossRef
12.
go back to reference Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV. Continuous subcutaneous insulin infusion: a new way to achieve strict metabolic control, decrease severe hypoglycemia and enhance coping in adolescents with type I diabetes. Diabetes Care 1999;22 11:1779–84.PubMedCrossRef Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV. Continuous subcutaneous insulin infusion: a new way to achieve strict metabolic control, decrease severe hypoglycemia and enhance coping in adolescents with type I diabetes. Diabetes Care 1999;22 11:1779–84.PubMedCrossRef
13.
go back to reference Ahern JA, Boland EA, Doane R, Ahern JJ, Rose P, Vincent M, et al. Insulin pump therapy in pediatrics: a therapeutic alternative to safely lower therapy HbA1c levels across all age groups. Pediatric Diabetes 2002;3 1:10–5.PubMedCrossRef Ahern JA, Boland EA, Doane R, Ahern JJ, Rose P, Vincent M, et al. Insulin pump therapy in pediatrics: a therapeutic alternative to safely lower therapy HbA1c levels across all age groups. Pediatric Diabetes 2002;3 1:10–5.PubMedCrossRef
14.
go back to reference Maniatis AK, Klingensmith GJ, Slover RH, Mowry CJ, Chase HP. Continuous subcutaneous insulin infusion therapy for children and adolescents: an option for routine diabetes care. Pediatrics 2001;107 2:351–6.PubMedCrossRef Maniatis AK, Klingensmith GJ, Slover RH, Mowry CJ, Chase HP. Continuous subcutaneous insulin infusion therapy for children and adolescents: an option for routine diabetes care. Pediatrics 2001;107 2:351–6.PubMedCrossRef
15.
go back to reference Plotnick LP, Clark LM, Brancati FL, Erlinger T. Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes. Diabetes Care 2003;26 4:1142–46.PubMedCrossRef Plotnick LP, Clark LM, Brancati FL, Erlinger T. Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes. Diabetes Care 2003;26 4:1142–46.PubMedCrossRef
16.
go back to reference Sulli N, Shashaj B. Continuous subcutaneous insulin infusion in children and adolescents with diabetes mellitus: decreased HbA1c with low risk of hypoglycemia. J Pediatr Endocrinol Metab 2003;16 3:393–9.PubMed Sulli N, Shashaj B. Continuous subcutaneous insulin infusion in children and adolescents with diabetes mellitus: decreased HbA1c with low risk of hypoglycemia. J Pediatr Endocrinol Metab 2003;16 3:393–9.PubMed
17.
go back to reference Willi SM, Planton J, Egede L, Schwarz S. Benefits of continuous subcutaneous insulin infusion in children with type 1 diabetes mellitus. J Pediatr 2003;143 6:796–801.PubMedCrossRef Willi SM, Planton J, Egede L, Schwarz S. Benefits of continuous subcutaneous insulin infusion in children with type 1 diabetes mellitus. J Pediatr 2003;143 6:796–801.PubMedCrossRef
18.
go back to reference Liberatore R Jr, Perlman K, Buccino J, Artiles-Sisk A, Daneman D. Continuous insulin infusion pump treatment in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2004;17 2:223–6.PubMed Liberatore R Jr, Perlman K, Buccino J, Artiles-Sisk A, Daneman D. Continuous insulin infusion pump treatment in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2004;17 2:223–6.PubMed
19.
go back to reference Mack-Fogg JE, Orlowski CC, Jospe N. Continuous subcutaneous insulin infusion in toddlers and children with type 1 diabetes mellitus is safe and effective. Pediatric Diabetes 2005;6 1:17–21.PubMedCrossRef Mack-Fogg JE, Orlowski CC, Jospe N. Continuous subcutaneous insulin infusion in toddlers and children with type 1 diabetes mellitus is safe and effective. Pediatric Diabetes 2005;6 1:17–21.PubMedCrossRef
20.
go back to reference Weinzimer SA, Ahern JA, Doyle EA, Vincent MR, Dziura J, Steffen AT, et al. Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: a follow-up report. Pediatrics 2004;114 6:1601–5.PubMedCrossRef Weinzimer SA, Ahern JA, Doyle EA, Vincent MR, Dziura J, Steffen AT, et al. Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: a follow-up report. Pediatrics 2004;114 6:1601–5.PubMedCrossRef
21.
go back to reference Tubiana-Rufi N, deLonlay P, Bloch J, Czernichow P. Remission of severe hypoglycemic incidents in young diabetic children treated with subcutaneous infusion. Arch Pediatr 1996;3 10:969–76.PubMedCrossRef Tubiana-Rufi N, deLonlay P, Bloch J, Czernichow P. Remission of severe hypoglycemic incidents in young diabetic children treated with subcutaneous infusion. Arch Pediatr 1996;3 10:969–76.PubMedCrossRef
22.
go back to reference Litton J, Rice A, Friedman N, Oden J, Lee MM, Freemark M. Insulin pump therapy in toddlers and pre-school children with type 1 diabetes mellitus. J Pediatr 2002;141 4:490–5.PubMedCrossRef Litton J, Rice A, Friedman N, Oden J, Lee MM, Freemark M. Insulin pump therapy in toddlers and pre-school children with type 1 diabetes mellitus. J Pediatr 2002;141 4:490–5.PubMedCrossRef
23.
go back to reference Shehadeh N, Battelino T, Galatzer A, Naveh T, Hadash A, de Vries L, et al. Insulin pump therapy for 1–6 year old children with type 1 diabetes. Isr Med Assoc J 2004;6 5:284–6.PubMed Shehadeh N, Battelino T, Galatzer A, Naveh T, Hadash A, de Vries L, et al. Insulin pump therapy for 1–6 year old children with type 1 diabetes. Isr Med Assoc J 2004;6 5:284–6.PubMed
24.
go back to reference Springer D, Dziura J, Tamborlane WV, Steffen AT, Ahern JH, Vincent M, Weinzimer SA. Optimal control of type 1 diabetes in youth receiving intensive treatment. J Pediatr 2006;149:227–32.PubMedCrossRef Springer D, Dziura J, Tamborlane WV, Steffen AT, Ahern JH, Vincent M, Weinzimer SA. Optimal control of type 1 diabetes in youth receiving intensive treatment. J Pediatr 2006;149:227–32.PubMedCrossRef
25.
go back to reference The DCCT Research Group. The absence of a glycemic threshold for the development of long-term complications the prospective of the diabetes control and complications trial. Diabetes 1996;45:1289–98.CrossRef The DCCT Research Group. The absence of a glycemic threshold for the development of long-term complications the prospective of the diabetes control and complications trial. Diabetes 1996;45:1289–98.CrossRef
26.
go back to reference de Beaufort CE, Houtzagers CM, Bruining GJ, Aarsen RS, den Boer NC, Grose WF, et al. Continuous subcutaneous insulin infusion (CSII) versus conventional injection therapy in newly diagnosed diabetic children: two-year follow-up of a randomized, prospective trial. Diabet Med 1989;6 9:766–71.PubMedCrossRef de Beaufort CE, Houtzagers CM, Bruining GJ, Aarsen RS, den Boer NC, Grose WF, et al. Continuous subcutaneous insulin infusion (CSII) versus conventional injection therapy in newly diagnosed diabetic children: two-year follow-up of a randomized, prospective trial. Diabet Med 1989;6 9:766–71.PubMedCrossRef
27.
go back to reference Weintrob N, Benzaquen H, Galatzar A, Shalitin S, Lazar L, Fayman G, et al. Comparison of continuous subcutaneous insulin infusion and multiple daily injection regimens in children with type 1 diabetes: a randomized open crossover trial. Pediatrics 2003;112 3 Pt 1:559–64.PubMedCrossRef Weintrob N, Benzaquen H, Galatzar A, Shalitin S, Lazar L, Fayman G, et al. Comparison of continuous subcutaneous insulin infusion and multiple daily injection regimens in children with type 1 diabetes: a randomized open crossover trial. Pediatrics 2003;112 3 Pt 1:559–64.PubMedCrossRef
28.
go back to reference Heise T, Nosek L, Ronn BB, Endahl L, Heinemann L, Kapitza C, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes 2004;53 6:1614–20.PubMedCrossRef Heise T, Nosek L, Ronn BB, Endahl L, Heinemann L, Kapitza C, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes 2004;53 6:1614–20.PubMedCrossRef
29.
go back to reference Lepore M, Pampanelli S, Fanelli C, Porcellati F, Bartocci L, Di Vincenzo A, et al. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 2000;49 12:2142–8.PubMedCrossRef Lepore M, Pampanelli S, Fanelli C, Porcellati F, Bartocci L, Di Vincenzo A, et al. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes 2000;49 12:2142–8.PubMedCrossRef
30.
go back to reference Kaplan W, Rodriguez LM, Smith OE, Haymond MW, Heptulla RA. Effects of mixing glargine and short-acting insulin analogs on glucose control. Diabetes Care 2004;27:2739–40.PubMedCrossRef Kaplan W, Rodriguez LM, Smith OE, Haymond MW, Heptulla RA. Effects of mixing glargine and short-acting insulin analogs on glucose control. Diabetes Care 2004;27:2739–40.PubMedCrossRef
31.
go back to reference Schober E, Schoenle E, Van Dyk J, Wernicke-Panten K, Pediatric Study Group of Insulin Glargine. Comparative trial between insulin glargine and NPH insulin in children and adolescents with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2002;15 4:369–76.PubMed Schober E, Schoenle E, Van Dyk J, Wernicke-Panten K, Pediatric Study Group of Insulin Glargine. Comparative trial between insulin glargine and NPH insulin in children and adolescents with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2002;15 4:369–76.PubMed
32.
go back to reference Murphy NP, Keane SM, Ong KK, Ford-Adams M, Edge JA, Acerini CL, et al. Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens. Diabetes Care 2003;26 3:799–804.PubMedCrossRef Murphy NP, Keane SM, Ong KK, Ford-Adams M, Edge JA, Acerini CL, et al. Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens. Diabetes Care 2003;26 3:799–804.PubMedCrossRef
33.
go back to reference White NH, Tamborlane W, Ususkin K. Less variability in blood glucose values with insulin glargine vs intermediate-acting insulin (NPH or Lente) in adolescents with T1DM. Diabetes 2006;55 Suppl 1:A138. White NH, Tamborlane W, Ususkin K. Less variability in blood glucose values with insulin glargine vs intermediate-acting insulin (NPH or Lente) in adolescents with T1DM. Diabetes 2006;55 Suppl 1:A138.
34.
go back to reference Doyle EA, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV. A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. Diabetes Care 2004;27 7:1554–8.PubMedCrossRef Doyle EA, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV. A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. Diabetes Care 2004;27 7:1554–8.PubMedCrossRef
35.
go back to reference Wilson DM, Buckingham BA, Kunselman EL, Sullivan MM, Paguntalan HU, Gittelman SE. A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Diabetes Care 2005;28 1:15–9.PubMedCrossRef Wilson DM, Buckingham BA, Kunselman EL, Sullivan MM, Paguntalan HU, Gittelman SE. A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Diabetes Care 2005;28 1:15–9.PubMedCrossRef
36.
go back to reference Di Meglio LA, Pottorff TM, Boyd SR, France L, Fineberg N, Eugster EA. A randomized, controlled study of insulin pump therapy in diabetic preschoolers. J Pediatr 2004;145 3:380–4.CrossRef Di Meglio LA, Pottorff TM, Boyd SR, France L, Fineberg N, Eugster EA. A randomized, controlled study of insulin pump therapy in diabetic preschoolers. J Pediatr 2004;145 3:380–4.CrossRef
37.
go back to reference Fox LA, Buckloh LM, Smith SD, Wysocki T, Mauras N. A randomized controlled trial of insulin pump therapy in young children with type 1 diabetes. Diabetes Care 2005;28:1277–81.PubMedCrossRef Fox LA, Buckloh LM, Smith SD, Wysocki T, Mauras N. A randomized controlled trial of insulin pump therapy in young children with type 1 diabetes. Diabetes Care 2005;28:1277–81.PubMedCrossRef
38.
go back to reference Jeha GS. Karaviti LP. Anderson B. Smith EO. Donaldson S. McGirk TS. Haymond MW. Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursions and the risk of hypoglycemia. Diabetes Technol Ther 2005;7:876–84.PubMedCrossRef Jeha GS. Karaviti LP. Anderson B. Smith EO. Donaldson S. McGirk TS. Haymond MW. Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursions and the risk of hypoglycemia. Diabetes Technol Ther 2005;7:876–84.PubMedCrossRef
39.
go back to reference The DirecNet Study Group. Impact of exercise on overnight glycemic control in children with type 1 diabetes. J Pediatr 2005;147:528–34.CrossRef The DirecNet Study Group. Impact of exercise on overnight glycemic control in children with type 1 diabetes. J Pediatr 2005;147:528–34.CrossRef
40.
go back to reference The DirecNet Study Group. The effects of aerobic exercise on glucose and counter-regulatory hormone levels in children with type 1 diabetes. Diabetes Care 2006;29:20–5.CrossRef The DirecNet Study Group. The effects of aerobic exercise on glucose and counter-regulatory hormone levels in children with type 1 diabetes. Diabetes Care 2006;29:20–5.CrossRef
41.
go back to reference The Diabetes Research in Children Network (DirecNet) Study Group. Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin. Diabetes Care 2006;29:2200–4.CrossRef The Diabetes Research in Children Network (DirecNet) Study Group. Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin. Diabetes Care 2006;29:2200–4.CrossRef
42.
go back to reference Burdick J, Chase HP, Slover RH, Knievel K, Scrimgeour L, Maniatis AK, et al. Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy. Pediatrics 2004;113 3 Pt 1:e221–4.PubMedCrossRef Burdick J, Chase HP, Slover RH, Knievel K, Scrimgeour L, Maniatis AK, et al. Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy. Pediatrics 2004;113 3 Pt 1:e221–4.PubMedCrossRef
43.
go back to reference Danne T, Battelino T, Kordonouri O, Hanas R, Klinkert C, Ludvigsson J, et al. A cross-sectional international survey of continuous subcutaneous insulin infusion in 377 children and adolescents with type 1 diabetes mellitus from 10 countries. Pediatric Diabetes 2005;6:193–8.PubMedCrossRef Danne T, Battelino T, Kordonouri O, Hanas R, Klinkert C, Ludvigsson J, et al. A cross-sectional international survey of continuous subcutaneous insulin infusion in 377 children and adolescents with type 1 diabetes mellitus from 10 countries. Pediatric Diabetes 2005;6:193–8.PubMedCrossRef
44.
go back to reference Sullivan-Bolyai S, Knafl K, Tamborlane W, Grey M. Parent’s reflections on managing their children’s diabetes with insulin pumps. J Nursing Scholarsh 2004;36 4:316–23.CrossRef Sullivan-Bolyai S, Knafl K, Tamborlane W, Grey M. Parent’s reflections on managing their children’s diabetes with insulin pumps. J Nursing Scholarsh 2004;36 4:316–23.CrossRef
45.
go back to reference Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV. CSII: a “new” way to achieve strict metabolic control, decrease severe hypoglycemia and enhance coping in adolescents with type 1 diabetes. Diabetes Care 1999;22:1779–84.PubMedCrossRef Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV. CSII: a “new” way to achieve strict metabolic control, decrease severe hypoglycemia and enhance coping in adolescents with type 1 diabetes. Diabetes Care 1999;22:1779–84.PubMedCrossRef
46.
go back to reference Low KG, Massa L, Lehman D, Olshan JS. Insulin pump use in young adolescents with type 1 diabetes: a descriptive study. Pediatric Diabetes 2005;6 1:22–31.PubMedCrossRef Low KG, Massa L, Lehman D, Olshan JS. Insulin pump use in young adolescents with type 1 diabetes: a descriptive study. Pediatric Diabetes 2005;6 1:22–31.PubMedCrossRef
47.
go back to reference Tamborlane WV, Fredrickson L. Insulin pump therapy of childhood diabetes: guidelines for us. Treat Endocrinol 2003;2:11–21.PubMedCrossRef Tamborlane WV, Fredrickson L. Insulin pump therapy of childhood diabetes: guidelines for us. Treat Endocrinol 2003;2:11–21.PubMedCrossRef
48.
go back to reference Ahern JA, Ramchandani N, Cooper J, Himmel A, Silver D, Tamborlane WV. Using a primary nurse manager to implement DCCT recommendations in a large pediatric program. Diabetes Educ 2000;26 6:990–4.PubMed Ahern JA, Ramchandani N, Cooper J, Himmel A, Silver D, Tamborlane WV. Using a primary nurse manager to implement DCCT recommendations in a large pediatric program. Diabetes Educ 2000;26 6:990–4.PubMed
49.
go back to reference Melzer SM, Richards GE, Covington ML. Reimbursement and costs of pediatric ambulatory diabetes care by using the resource-based relative value scale: is multidisciplinary care financially viable? Pediatric Diabetes 2004;5 3:133–42.PubMedCrossRef Melzer SM, Richards GE, Covington ML. Reimbursement and costs of pediatric ambulatory diabetes care by using the resource-based relative value scale: is multidisciplinary care financially viable? Pediatric Diabetes 2004;5 3:133–42.PubMedCrossRef
50.
go back to reference Boland E, Monsod T, Brandt CA, Fernando S, DeLucia M, Tamborlane WV. Limitations of conventional methods of self-monitoring of blood glucose: Lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes. Diabetes Care 2001;24:1858–62.PubMedCrossRef Boland E, Monsod T, Brandt CA, Fernando S, DeLucia M, Tamborlane WV. Limitations of conventional methods of self-monitoring of blood glucose: Lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes. Diabetes Care 2001;24:1858–62.PubMedCrossRef
51.
go back to reference Diabetes Research in Children Network (DirecNet) Study Group. The accuracy of the CGMS in children with type 1 diabetes: results of the diabetes research in children network (DirecNet) accuracy study. Diabetes Technol Ther 2003;5 5:781–9.CrossRef Diabetes Research in Children Network (DirecNet) Study Group. The accuracy of the CGMS in children with type 1 diabetes: results of the diabetes research in children network (DirecNet) accuracy study. Diabetes Technol Ther 2003;5 5:781–9.CrossRef
52.
go back to reference Diabetes Research in Children Network (DirecNet) Study Group. The accuracy of the GlucoWatch G2 biographer in children with type 1 diabetes: results of the diabetes research in children network (DirecNet) accuracy study. Diabetes Technol Ther 2003;5 5:791–800.CrossRef Diabetes Research in Children Network (DirecNet) Study Group. The accuracy of the GlucoWatch G2 biographer in children with type 1 diabetes: results of the diabetes research in children network (DirecNet) accuracy study. Diabetes Technol Ther 2003;5 5:791–800.CrossRef
53.
go back to reference Diabetes Research in Children Network (DirecNet) Study Group. A multicenter study of the accuracy of the One Touch Ultra home glucose meter in children with type 1 diabetes. Diabetes Technol Ther 2003;5 6:933–41.CrossRef Diabetes Research in Children Network (DirecNet) Study Group. A multicenter study of the accuracy of the One Touch Ultra home glucose meter in children with type 1 diabetes. Diabetes Technol Ther 2003;5 6:933–41.CrossRef
54.
go back to reference The DirecNet Study Group. Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study. Diabetes Technol Ther 2005;7 1:109–14.CrossRef The DirecNet Study Group. Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study. Diabetes Technol Ther 2005;7 1:109–14.CrossRef
55.
go back to reference DirecNet Study Group. Accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with T1DM. Diabetes 2006;55 Suppl 1:A91–2. DirecNet Study Group. Accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with T1DM. Diabetes 2006;55 Suppl 1:A91–2.
56.
go back to reference Weinzimer SA, Steil GM, Kurtz N, Swan KL, Tamborlane WV. Automated feedback-controlled insulin delivery in children with type 1 diabetes mellitus: a preliminary report. Diabetes 2006;55 Suppl 1:A102. Weinzimer SA, Steil GM, Kurtz N, Swan KL, Tamborlane WV. Automated feedback-controlled insulin delivery in children with type 1 diabetes mellitus: a preliminary report. Diabetes 2006;55 Suppl 1:A102.
Metadata
Title
The renaissance of insulin pump treatment in childhood type 1 diabetes
Authors
William V. Tamborlane
Karena Swan
Kristin A. Sikes
Amy T. Steffen
Stuart A Weinzimer
Publication date
01-09-2006
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 3/2006
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-006-9018-9

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