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Open Access 06-08-2022 | Glioma | Review

Health-related quality of life in adults with low-grade gliomas: a systematic review

Authors: Ben Rimmer, Iakov Bolnykh, Lizzie Dutton, Joanne Lewis, Richéal Burns, Pamela Gallagher, Sophie Williams, Vera Araújo-Soares, Fiona Menger, Linda Sharp

Published in: Quality of Life Research | Issue 3/2023

Abstract

Purpose

Low-grade glioma (LGG) patients may face health-related quality-of-life (HRQoL) impairments, due to the tumour, treatment and associated side-effects and prospects of progression. We systematically identified quantitative studies assessing HRQoL in adult LGG patients, for: aspects of HRQoL impacted; comparisons with non-cancer controls (NCC) and other groups; temporal trends; and factors associated with HRQoL.

Methods

MEDLINE, CINAHL, Embase, PubMed, and PsycINFO were systematically searched from inception to 14th September 2021. Following independent screening of titles and abstracts and full-texts, population and study characteristics, and HRQoL findings were abstracted from eligible papers, and quality appraised. Narrative synthesis was conducted.

Results

Twenty-nine papers reporting 22 studies (cross-sectional, n = 13; longitudinal, n = 9) were identified. Papers were largely good quality, though many excluded patients with cognitive and communication impairments. Comparators included high-grade gliomas (HGG) (n = 7); NCCs (n = 6) and other patient groups (n = 3). Nineteen factors, primarily treatment (n = 8), were examined for association with HRQoL. There was substantial heterogeneity in HRQoL instruments used, factors and aspects of HRQoL assessed and measurement timepoints. HRQoL, primarily cognitive functioning and fatigue, in adult LGG patients is poor, and worse than in NCCs, though better than in HGG patients. Over time, HRQoL remained low, but stable. Epilepsy/seizure burden was most consistently associated with worse HRQoL.

Conclusion

LGG patients experience wide-ranging HRQoL impairments. HRQoL in those with cognitive and communication impairments requires further investigation. These findings may help clinicians recognise current supportive care needs and inform types and timings of support needed, as well as inform future interventions.

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Title: Health-related quality of life in adults with low-grade gliomas: a systematic review
Authors: Ben Rimmer
Iakov Bolnykh
Lizzie Dutton
Joanne Lewis
Richéal Burns
Pamela Gallagher
Sophie Williams
Vera Araújo-Soares
Fiona Menger
Linda Sharp
Publication date: 06-08-2022
Publisher: Springer International Publishing
Keywords: Glioma
Glioma
Glioma
Published in: Quality of Life Research / Issue 3/2023
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-022-03207-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Health-related quality of life in adults with low-grade gliomas: a systematic review

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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