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European Archives of Psychiatry and Clinical Neuroscience

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01-12-2006 | ORIGINAL PAPER

Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003

Authors: Arja Mainio, MD, PhD, Satu Tuunanen, BM, Helinä Hakko, PhD, Asko Niemelä, MD, John Koivukangas, MD, PhD, Pirkko Räsänen, MD, PhD

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 8/2006

Abstract

Objectives

To assess the long-term survival of brain tumor patients, and in particular to evaluate the relation of quality of life (QOL) to survival among low-grade glioma patients.

Methods

The postoperative survival of 101 brain tumor patients was followed from surgery (1990–1992) until the end of the year 2003. Depression was evaluated by the Beck Depression Inventory (BDI) and QOL with Sintonen’s 15D scale before operation and at one year as well as at five years after operation.

Results

The mean survival times in years (SD) were significantly related to tumor malignancy, being the shortest, 1.9 (0.6), for patients with high-grade gliomas, while patients with low-grade gliomas or a benign brain tumor had mean survival times of 9.1 (1.0) and 11.6 (0.5), respectively. At all follow-ups, depressed low-grade glioma patients had a significantly shorter survival time, 3.3–5.8 years, compared to non-depressed low-grade glioma patients, 10.0–11.7 years. A decreased level of QOL in low-grade glioma patients was significantly related to the shorter survival.

Conclusions

The results suggest that depression and decreased QOL among low-grade glioma patients is related to shorter survival at long-term follow-up. Decreased QOL may serve as an indicator for poor prognosis in low-grade glioma patients.

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Title: Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003
Authors: Arja Mainio, MD, PhD
Satu Tuunanen, BM
Helinä Hakko, PhD
Asko Niemelä, MD
John Koivukangas, MD, PhD
Pirkko Räsänen, MD, PhD
Publication date: 01-12-2006
Publisher: Steinkopff-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 8/2006
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-006-0674-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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