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Open Access 01-07-2017

Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life

Authors: Eline H. van Roekel, Martijn J. L. Bours, Malou E. M. te Molder, José J. L. Breedveld-Peters, Steven W. M. Olde Damink, Leo J. Schouten, Silvia Sanduleanu, Geerard L. Beets, Matty P. Weijenberg

Published in: Quality of Life Research | Issue 7/2017

Abstract

Purpose

Increased visceral adiposity (visceral obesity) and muscle wasting (sarcopenia) at colorectal cancer (CRC) diagnosis, quantified by computed tomography (CT) image analysis, have been unfavorably associated with short-term clinical outcomes and survival, but associations with long-term health-related quality of life (HRQoL) have not been investigated. We studied associations of visceral adiposity, muscle fat infiltration, muscle mass, and sarcopenia at CRC diagnosis with HRQoL 2–10 years post-diagnosis.

Methods

A cross-sectional study was conducted in 104 stage I‒III CRC survivors, diagnosed at Maastricht University Medical Center+, the Netherlands (2002–2010). Diagnostic CT images at the level of the third lumbar vertebra were analyzed to retrospectively determine visceral adipose tissue area (cm²); intermuscular adipose tissue area (cm²) and mean muscle attenuation (Hounsfield units) as measures of muscle fat infiltration; and skeletal muscle index (SMI, cm²/m²) as measure of muscle mass and for determining sarcopenia.

Results

Participants showed a large variation in body composition parameters at CRC diagnosis with a mean visceral adipose tissue area of 136.1 cm² (standard deviation: 93.4) and SMI of 47.8 cm²/m² (7.2); 47% was classified as being viscerally obese, and 32% as sarcopenic. In multivariable linear regression models, associations of the body composition parameters with long-term global quality of life, physical, role and social functioning, disability, fatigue, and distress were not significant, and observed mean differences were below predefined minimal important differences.

Conclusions

Although visceral obesity and sarcopenia are relatively common at CRC diagnosis, we found no significant associations of these parameters with long-term HRQoL in stage I–III CRC survivors.

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Title: Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life
Authors: Eline H. van Roekel
Martijn J. L. Bours
Malou E. M. te Molder
José J. L. Breedveld-Peters
Steven W. M. Olde Damink
Leo J. Schouten
Silvia Sanduleanu
Geerard L. Beets
Matty P. Weijenberg
Publication date: 01-07-2017
Publisher: Springer International Publishing
Published in: Quality of Life Research / Issue 7/2017
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-017-1539-z

2024 ASCO Annual Meeting

Springer Medicine

Associations of adipose and muscle tissue parameters at colorectal cancer diagnosis with long-term health-related quality of life

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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