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Published in: Pituitary 1/2017

01-02-2017

Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary

Authors: Luis V. Syro, Fabio Rotondo, Carlos A. Serna, Leon D. Ortiz, Kalman Kovacs

Published in: Pituitary | Issue 1/2017

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Abstract

Introduction

Histologic, immunohistochemical and electron microscopic studies have provided conclusive evidence that a marked diversity exists between tumors which secrete growth hormone (GH) in excess. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH—releasing hormone secreting tumors or in familial pituitary tumor syndromes.

Materials and methods

A literature search was performed for information regarding pathology, GH-producing tumors and acromegaly.

Results

This review summarizes the current knowledge on the morphology of GH-producing and silent GH adenomas, as well as GH hyperplasia of the pituitary.

Conclusion

The importance of morphologic classification and identification of different subgroups of patients with GH-producing adenomas and their impact on clinical management is discussed.
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Metadata
Title
Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary
Authors
Luis V. Syro
Fabio Rotondo
Carlos A. Serna
Leon D. Ortiz
Kalman Kovacs
Publication date
01-02-2017
Publisher
Springer US
Published in
Pituitary / Issue 1/2017
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-016-0748-8

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