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01-04-2011 | Case Report

Central nervous system Hodgkin lymphoma: case report and review of the literature

Authors: Sara Torgerson, Horatiu Olteanu, Matthew Tinguely, Timothy S. Fenske

Published in: Journal of Neuro-Oncology | Issue 2/2011

Abstract

Central nervous system (CNS) involvement by Hodgkin lymphoma (HL) is extremely rare, accounting for 0.5% or less of HL cases. In contrast, CNS involvement can occur in 5–30% of patients with non-Hodgkin lymphoma. CNS HL can present at any point in the course of HL, most commonly during relapsing disease, and has been described in both immunocompromised and immunocompetent patients. We describe a case of HL affecting the CNS and bone marrow on initial presentation in a 79-year-old immunocompetent female with a prior history of squamous cell carcinoma of the larynx and adenocarcinoma of the lung. Following the case report, a review of the literature on CNS HL is presented.

Anselmo A, Proia A, Cartoni C, Baroni CD, Maurizi Enrici R, Delfini R, Avvisati G (1996) Meningeal localization in a patient with Hodgkin’s disease. Description of a case and review of the literature. Ann Oncol 7:1071–1075PubMed

Apollonsky N, Edelman M, Johnson A, Bhuiya T, Karayalcin G (2008) Intracerebral presentation of Hodgkin disease mimicking meningioma in a young woman: case presentation with literature review. J Pediatr Hematol Oncol 30(5):369–372PubMedCrossRef

Ashby MA, Barber PC, Holmes AE, Freer C, Collins RD (1988) Primary intracranial Hodgkin’s disease: a case report and discussion. Am J Surg Patholog 12(4):294–299CrossRef

Figueroa B, Brown J, Nascimento A, Fisher D, Tuli S (2004) Hodgkin’s lymphoma of the CNS masquerading as meningioma. J Clin Oncol 22:4228–4230PubMedCrossRef

Gerstner ER, Abrey LE, Schiff D, Ferreri AJ, Lister A, Montoto S, Tsang R, Thiel E, Graus F, Behringer D, Illerhaus G, Weaver S, Wen P, Voloschin A, Harris NL, Batchelor TT (2008) CNS Hodgkin lymphoma. Blood 112(5):1658–1661PubMedCrossRef

Hirmiz K, Foyle A, Wilke D, Burrell S, Brownstone R, Ago C, Pahil R, Couban S (2004) Intracranial presentation of systemic Hodgkin’s disease. Leuk Lymphoma 45(8):1667–1671PubMedCrossRef

Morawa E, Ragam A, Sirota R, Nabhan C (2007) Hodgkin’s lymphoma involving the CNS. J Clin Oncol 25(11):1437–1438PubMedCrossRef

Re D, Fuchs M, Schober T, Engert A, Diehl V (2007) CNS involvement in Hodgkin’s lymphoma. J Clin Oncol 25(21):3182PubMedCrossRef

Shet AS, Saba N, Rausch D, Belzer M (2004) Intra-cranial lesions in a patient with Hodgkin lymphoma. Leuk Lymphoma 45(2):419–422PubMedCrossRef

10.

Bierman P, Giglio P (2005) Diagnosis and treatment of central nervous system involvement in non-Hodgkin’s lymphoma. Hematol Oncol Clin N Am 19:597–609CrossRef

11.

Hollender A, Kvaloy S, Nome O, Skovlun E, Lote K, Holte H (2002) Central nervous system involvement following diagnosis of non-Hodgkin’s lymphoma: a risk model. Ann Oncol 13:1099–1107PubMedCrossRef

12.

Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F (1999) Primary extranodal non-Hodgkin’s lymphomas. Part 2: head and neck, central nervous system and other less common sites. Ann Oncol 10:1023–1033PubMedCrossRef

13.

Chim CS, Shek TW, Liang R (2000) Unusual features of Hodgkin disease. Case 2: meningeal relapse in Hodgkin’s disease. J Clin Oncol 18(5):1150–1155

14.

Nakayama H, Tokuuye K, Kagami Y, Sumi M, Murayama S, Kawashima M, Imai A, Ikeda H, Tobinai K (2000) Brain involvement in Hodgkin’s disease: case reports and review of the literature. Radiat Med 18(3):205–208PubMed

15.

Biagi J, MacKenzie R, Lim M, Sapp M, Berinstein N (2000) Primary Hodgkin’s disease of the CNS in an immunocompetent patient: a case study and review of the literature. Neuro Oncol 2(4):239–243PubMed

16.

Klein R, Müllges W, Bendszus M, Woydt M, Kreipe H, Roggendorf W (1999) Primary intracerebral Hodgkin’s disease: report of a case with Epstein-Barr virus association and review of the literature. Am J Surg Pathol 23(4):477–481PubMedCrossRef

17.

Massarweh S, Udden MM, Shahab I, Kroll M, Sears DA, Lynch GR, Teh BS, Lu HH (2003) HIV-related Hodgkin’s disease with central nervous system involvement and association with Epstein-Barr virus. Am J Hematol 72(3):216–219PubMedCrossRef

18.

Guermazi A, Brice P, de Kerviler E, Fermé C, Hennequin C, Mengnin V, Frija J (2001) Extranodal Hodgkin disease: spectrum of disease. Radiographics 21:161–179PubMed

Title: Central nervous system Hodgkin lymphoma: case report and review of the literature
Authors: Sara Torgerson
Horatiu Olteanu
Matthew Tinguely
Timothy S. Fenske
Publication date: 01-04-2011
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2011
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-010-0320-8

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Central nervous system Hodgkin lymphoma: case report and review of the literature

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