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01-04-2009 | Laboratory Investigation - Human/Animal Tissue

Growth factor receptors signaling in glioblastoma cells: therapeutic implications

Authors: Mia Carapancea, Oana Alexandru, Ani S. Fetea, Laura Dragutescu, Juan Castro, Ada Georgescu, A. Popa-Wagner, Magnus L. Bäcklund, Rolf Lewensohn, Anica Dricu

Published in: Journal of Neuro-Oncology | Issue 2/2009

Abstract

In this study, we investigated the protein expression of platelet-derived growth factor receptor (PDGFR), insulin like growth factor-1 receptor (IGF-1R), phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated kinase (ERK1/2) in five primary glioblastoma (GB), with a view to their possible use as therapeutic targets. Our results demonstrated that appreciable levels of these proteins could be detected in the analysed GB cell lines, except for a low level of PDGFR and ERK1/2 expression in one GB cell line. The small molecule inhibitors towards IGF-1R, PDGFR, PI3-K and ERK1/2 respectively, have only modest or no anti-tumour activity on GB cells and therefore their combination with other therapy modalities was analysed. The interaction between small inhibitors and radiation was mostly additive or sub-additive; synergistic interaction was found in five of forty analysed combinations. Our results showed that GB cells are in general resistant to treatment and illustrate the difficulties in predicting the treatment response in malignant gliomas.

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Title: Growth factor receptors signaling in glioblastoma cells: therapeutic implications
Authors: Mia Carapancea
Oana Alexandru
Ani S. Fetea
Laura Dragutescu
Juan Castro
Ada Georgescu
A. Popa-Wagner
Magnus L. Bäcklund
Rolf Lewensohn
Anica Dricu
Publication date: 01-04-2009
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2009
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9753-8

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Growth factor receptors signaling in glioblastoma cells: therapeutic implications

Abstract

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Abstract

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