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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-12-2013

Multifaceted Leptin Network: The Molecular Connection Between Obesity and Breast Cancer

Authors: Neeraj K. Saxena, Dipali Sharma

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 3-4/2013

Abstract

High plasma levels of leptin, a major adipocytokine produced by adipocytes, are correlated with increased fat mass in obese state. Leptin is emerging as a key candidate molecule linking obesity with breast cancer. Acting via endocrine, paracrine, and autocrine manner, leptin impacts various stages of breast tumorigenesis from initiation and primary tumor growth to metastatic progression. Leptin also modulates the tumor microenvironment mainly through supporting migration of endothelial cells, neo-angiogenesis and sustaining recruitment of macrophage and monocytes. Various studies have shown that hyperactive leptin-signaling network leads to concurrent activation of multiple oncogenic pathways resulting in enhanced proliferation, decreased apoptosis, acquisition of mesenchymal phenotype, potentiated migration and enhanced invasion potential of tumor cells. Furthermore, the capability of leptin to interact with other molecular effectors of obese state including, estrogen, IGF-1, insulin, VEGF and inflammatory cytokines further increases its impact on breast tumor progression in obese state. This article presents an overview of the studies investigating the involvement of leptin in breast cancer.

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Title: Multifaceted Leptin Network: The Molecular Connection Between Obesity and Breast Cancer
Authors: Neeraj K. Saxena
Dipali Sharma
Publication date: 01-12-2013
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 3-4/2013
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-013-9308-2

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Other articles of this Issue 3-4/2013

Obesity and Breast Cancer: A Multipartite Connection

Insulin and IGFs in Obesity-Related Breast Cancer

Impact of Obesity on Development and Progression of Mammary Tumors in Preclinical Models of Breast Cancer

Clinical Studies Examining the Impact of Obesity on Breast Cancer Risk and Prognosis

Deconvoluting the Obesity and Breast Cancer Link: Secretome, Soil and Seed Interactions