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Journal of Mammary Gland Biology and Neoplasia
Published in: Journal of Mammary Gland Biology and Neoplasia 3-4/2013

01-12-2013

Leptin and Adiponectin: Emerging Therapeutic Targets in Breast Cancer

Author: Eva Surmacz

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 3-4/2013

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Abstract

Obesity is a recognized risk factor for breast cancer development and poorer response to therapy. Two major fat tissue-derived adipokines, leptin and adiponectin have been implicated in mammary carcinogenesis. Leptin appears to promote breast cancer progression through activation of mitogenic, antiapoptotic, and metastatic pathways, while adiponectin may restrict tumorigenic processes primarily by inhibiting cell metabolism. Furthermore, adiponectin is known to counteract detrimental leptin effects in breast cancer models. Thus, therapeutic inhibition of pro-neoplastic leptin pathways and reactivation of anti-neoplastic adiponectin signaling may benefit breast cancer patients, especially the obese subpopulation. This review focuses on current experimental strategies aiming at leptin and adiponectin pathways in breast cancer models. Novel leptin receptor antagonists and adiponectin receptor agonists as well as other compounds for therapeutic modulation of adipokine pathways are discussed in detail, including potential pharmacological advantages and limitations of these approaches.
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Metadata
Title
Leptin and Adiponectin: Emerging Therapeutic Targets in Breast Cancer
Author
Eva Surmacz
Publication date
01-12-2013
Publisher
Springer US
Published in
Journal of Mammary Gland Biology and Neoplasia / Issue 3-4/2013
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-013-9302-8

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