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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 7/2019

01-10-2019 | CME Review

Regulatory T Cells: the Many Faces of Foxp3

Authors: Peter Georgiev, Louis-Marie Charbonnier, Talal A. Chatila

Published in: Journal of Clinical Immunology | Issue 7/2019

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Abstract

Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary nor sufficient to specify many aspects of the Treg cell phenotype, its sustained expression in Treg cells is indispensable for their phenotypic stability, metabolic fitness, and regulatory function. In this review, we summarize recent advances in Treg cell biology, with a particular emphasis on the role of Foxp3 as a transcriptional modulator and metabolic gatekeeper essential to an effective immune regulatory response. We discuss these findings in the context of human inborn errors of immune dysregulation, with a focus on FOXP3 mutations, leading to Treg cell deficiency. We also highlight emerging concepts of therapeutic Treg cell reprogramming to restore tolerance in the settings of immune dysregulatory disorders.
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Metadata
Title
Regulatory T Cells: the Many Faces of Foxp3
Authors
Peter Georgiev
Louis-Marie Charbonnier
Talal A. Chatila
Publication date
01-10-2019
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 7/2019
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-019-00684-7

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