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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 7/2015

01-10-2015 | Original Article

Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in a Patient with Chronic Granulomatous Disease and Active Infection: A First Report

Authors: Mark Parta, Dianne Hilligoss, Corin Kelly, Nana Kwatemaa, Narda Theobald, Harry Malech, Elizabeth M. Kang

Published in: Journal of Clinical Immunology | Issue 7/2015

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Abstract

Purpose

We describe haploidentical hematopoietic cell transplantation (HCT) with high-dose post-transplant cyclophosphamide (PTCy) in a boy with x-linked chronic granulomatous disease (CGD).

Methods

A persistent and life-threatening fungal infection was the indication for HSCT. Non-myeloablative conditioning with PTCy (50 mg/kg days 3 and 4) was used in the absence of fully matched donors.

Results

Engraftment occurred on day 24. The patient experienced Grade 2 graft-versus-host disease of the skin and gastrointestinal tract and CMV infection, both of which were controlled. Chimerism was 100 % at days 30 and 6 months. Cessation of antifungal therapy was consistent with cure of the infection.

Conclusions

Haploidentical HCT with high-dose PTCy for CGD is feasible and succeeded even in the context of active infection.
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Metadata
Title
Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in a Patient with Chronic Granulomatous Disease and Active Infection: A First Report
Authors
Mark Parta
Dianne Hilligoss
Corin Kelly
Nana Kwatemaa
Narda Theobald
Harry Malech
Elizabeth M. Kang
Publication date
01-10-2015
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 7/2015
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-015-0204-y

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