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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 3/2011

01-06-2011

The Antiasthma Effect of Neonatal BCG Vaccination Does Not Depend on the Th17/Th1 but IL-17/IFN-γ Balance in a BALB/c Mouse Asthma Model

Authors: Yu Deng, Weichao Chen, Na Zang, Siming Li, Yan Luo, Ke Ni, Lijia Wang, Xiaohong Xie, Wei Liu, Xiqiang Yang, Zhou Fu, Enmei Liu

Published in: Journal of Clinical Immunology | Issue 3/2011

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Abstract

Objective

This study aimed to determine whether the protective effects of the Mycobacterium bovis Bacillus Calmette–Guérin (BCG) vaccination on allergic asthma are associated with the T helper (Th) 17/Th1 balance in a murine asthma model.

Methods

BALB/c neonates were vaccinated with BCG on the first day after birth, sensitized with ovalbumin, and then challenged with allergen. The resulting airway inflammation and responsiveness were measured. The levels of IL-17 and interferon (IFN)-γ in BALF and ratio of Th17/Th1 were investigated.

Results

We found that although BCG neonatal vaccination inhibited airway hyperresponsiveness and inflammation following allergen challenge in a BALB/c mouse asthma model, reduced levels of Th2 cytokines were not observed. However, BCG neonatal vaccination reduced IL-17 production and increased IFN-γ production in both the bronchoalveolar lavage fluid and the lung lymphocytes in asthmatic mice.

Conclusion

The antiasthma effects of neonatal BCG vaccination reversed the IL-17/IFN-γ imbalance in a murine asthma model but did not depend on modifying the Th17/Th1 balance.
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Metadata
Title
The Antiasthma Effect of Neonatal BCG Vaccination Does Not Depend on the Th17/Th1 but IL-17/IFN-γ Balance in a BALB/c Mouse Asthma Model
Authors
Yu Deng
Weichao Chen
Na Zang
Siming Li
Yan Luo
Ke Ni
Lijia Wang
Xiaohong Xie
Wei Liu
Xiqiang Yang
Zhou Fu
Enmei Liu
Publication date
01-06-2011
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 3/2011
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-010-9503-5

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