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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 4/2010

01-07-2010

Reduced CD27 Expression on Antigen-Specific CD4+ T Cells Correlates with Persistent Active Tuberculosis

Authors: Jing Jiang, Xianyuan Wang, Xinjing Wang, Zhihong Cao, Yanhua Liu, Mei Dong, Aihua Tong, Xiaoxing Cheng

Published in: Journal of Clinical Immunology | Issue 4/2010

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Abstract

Objective

CD27, a member of the tumor necrosis factor receptor family, has important role in generation of T cell immunity. In this study, association of CD27 expression on mycobacterial antigen-specific CD4+ T cells with pulmonary tuberculosis (TB) was investigated.

Methods

Mycobacterial antigen-specific CD4+ T cells were identified based on CD154 expression and CD27 expression on antigen-specific CD4 T cells was analyzed by flow cytometry.

Results

Compared with tuberculin-positive controls, patients with bacterial culture-positive pulmonary TB had significantly reduced CD27 expression on antigen-specific CD4 T cells. The persistent active TB patients had much lower percentages of CD27+ antigen-specific CD4 T cells than culture-positive new TB patients (P = 0.008) and healthy controls (P = 0.005). Logistic regression analysis on frequencies of CD27-expressing antigen-specific CD4 T cells and TB patients’ clinical characteristics indicated that low percentage of CD27+ antigen-specific CD4 T cells correlated significantly with persistent active tuberculosis (P = 0.002, odds ratio = 19.6).

Conclusion

It is concluded that frequency of CD27+ antigen-specific CD4 T cells could be used as an immunological marker for persistent active TB.
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Metadata
Title
Reduced CD27 Expression on Antigen-Specific CD4+ T Cells Correlates with Persistent Active Tuberculosis
Authors
Jing Jiang
Xianyuan Wang
Xinjing Wang
Zhihong Cao
Yanhua Liu
Mei Dong
Aihua Tong
Xiaoxing Cheng
Publication date
01-07-2010
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 4/2010
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-010-9418-1

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