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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 5/2009

01-09-2009

Osteoimmunology: Crosstalk Between the Immune and Bone Systems

Authors: Tomoki Nakashima, Hiroshi Takayanagi

Published in: Journal of Clinical Immunology | Issue 5/2009

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Abstract

Introduction

The interaction between the immune and skeletal systems has long been acknowledged, but investigation into rheumatoid arthritis (RA) as well as the various bone phenotypes found in immunocompromised gene-deficient mice has highlighted the importance of the dynamic interplay between the two systems. This has led to the recent emergence and subsequent rapid evolution of the field of osteoimmunology.

Bone Destruction with Arthritis as a RANKL Disease

In the bone destruction associated with RA, IL-17-producing helper T cells (TH17) play a major role by inducing receptor activator of nuclear factor-κB ligand (RANKL). RANKL stimulates osteoclastogenesis through nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which is well known as a crucial regulator of immunity.

New Players in Osteoimmunology

In addition to cellular interactions via cytokines, the immune and skeletal systems share various molecules, including transcription factors, signaling molecules, and membrane receptors.

Conclusion

The scope of osteoimmunology has grown to encompass a wide range of molecular and cellular interactions, the elucidation of which will provide a scientific basis for future therapeutic approaches to diseases of both the immune and skeletal systems.
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Metadata
Title
Osteoimmunology: Crosstalk Between the Immune and Bone Systems
Authors
Tomoki Nakashima
Hiroshi Takayanagi
Publication date
01-09-2009
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue 5/2009
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-009-9316-6

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