Published in:
01-11-2006
Frequency and Clinical Manifestations of Patients with Primary Immunodeficiency Disorders in Iran: Update from the Iranian Primary Immunodeficiency Registry
Authors:
NIMA REZAEI, ASGHAR AGHAMOHAMMADI, MOSTAFA MOIN, ZAHRA POURPAK, MASOUD MOVAHEDI, MOHAMMAD GHARAGOZLOU, LIDA ATAROD, BAHRAM MIRSAEID GHAZI, ANNA ISAEIAN, MARYAM MAHMOUDI, KAMRAN ABOLMAALI, DAVOUD MANSOURI, SABA ARSHI, NASER JAVAHER TARASH, ROYA SHERKAT, HEDAYAT AKBARI, REZA AMIN, ABDOLVAHAB ALBORZI, SARA KASHEF, REZA FARID, IRAJ MOHAMMADZADEH, MEHRNAZ SADEGHI SHABESTARI, MOHAMMAD NABAVI, ABOLHASSAN FARHOUDI
Published in:
Journal of Clinical Immunology
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Issue 6/2006
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Abstract
Primary immunodeficiency disorders (PID) are a heterogeneous group of diseases, characterized by an increased susceptibility to infections. A total of 930 patients (573 males and 357 females) are registered in Iranian PID Registry (IPIDR) during three decades. Predominantly antibody deficiencies were the most common (38.4%), followed by congenital defects of phagocyte number and/or function (28.3%), other well-defined immunodeficiency syndromes (17.7%), combined T- and B-cell immunodeficiencies (11.0%), complement deficiencies (2.4%), and diseases of immune dysregulation (2.3%). Common variable immunodeficiency was the most frequent disorder (20.8%), followed by chronic granulomatous disease, ataxia-telangiectasia, btk deficiency, selective IgA deficiency, and T-B-severe combined immunodeficiency. The frequency of other PID disorders was less than 50 in number (<5%). There is an increasing trend in recognition of more PID in the recent years. Construction of such registry is not only important for its epidemiological aspect but also for its role in increasing the physician's knowledge about such disorders.