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Journal of Assisted Reproduction and Genetics

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01-11-2007 | Original Papers

Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions

Authors: Ruth B. Lathi, Sara D. Mark, Lynn M. Westphal, Amin A. Milki

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2007

Abstract

Purpose

The objective of this study is to determine the rate of abnormalities detected by cytogenetic testing of first trimester miscarriages, in patients with and without an embryonic pole seen on ultrasound.

Materials and methods

A retrospective study of 272 D&Cs for missed abortions in an academic infertility practice from 1999 to 2006. Karyotype results were compared with transvaginal ultrasound findings. Chi-squared analysis was used with a P < 0.05 for significance.

Results

There was a high rate of abnormal karyotypes in all miscarriages (65%). Rates of abnormal karyotypes were 58% and 68% in cases with anembryonic gestations and those with a fetal pole seen, respectively (P > 0.05).

Conclusion

The high rate of abnormalities detected in both groups suggests that useful results can be obtained from chromosomal testing of the POC regardless of ultrasound findings. Further studies on the prognostic value and cost effectiveness of chromosomal testing are needed.

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Title: Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions
Authors: Ruth B. Lathi
Sara D. Mark
Lynn M. Westphal
Amin A. Milki
Publication date: 01-11-2007
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2007
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-007-9166-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cytogenetic testing of anembryonic pregnancies compared to embryonic missed abortions

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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