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International Ophthalmology

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01-12-2024 | Magnetic Resonance Imaging | Original Paper

Whole-orbit-based multiparametric assessment of disease activity of thyroid eye disease on Dixon MRI

Authors: Duojin Xia, Haiyang Zhang, Hui Wang, Mengda Jiang, Yan Tang, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

This study aimed to explore the diagnostic value of whole-orbit-based multiparametric assessment on Dixon MRI for the evaluation of the thyroid eye disease (TED) activity.

Methods

The retrospective study enrolled patients diagnosed as TED and obtained their axial and coronal Dixon MRI scans. Multiparameters were assessed, including water fraction (WF), fat fraction (FF) of extraocular muscles (EOMs), orbital fat (OF), and lacrimal gland (LG). The thickness of OF and herniation of LG were also measured. Univariable and multivariable logistic regression was applied to construct prediction models based on single or multiple structures. Receiver operating characteristic (ROC) curve analysis was also implemented.

Results

Univariable logistic analysis revealed significant differences in water fraction (WF) of the superior rectus (P = 0.018), fat fraction (FF) of the medial rectus (P = 0.029), WF of OF (P = 0.004), and herniation of LG (P = 0.012) between the active and inactive TED phases. Multivariable logistic analysis and corresponding receiver operating characteristic curve (ROC) analysis of each structure attained the area under the curve (AUC) values of 0.774, 0.771, and 0.729 for EOMs, OF, and LG, respectively, while the combination of the four imaging parameters generated a final AUC of 0.909.

Conclusions

Dixon MRI may be used for fine multiparametric assessment of multiple orbital structures. The whole-orbit-based model improves the diagnostic performance of TED activity evaluation.

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Title: Whole-orbit-based multiparametric assessment of disease activity of thyroid eye disease on Dixon MRI
Authors: Duojin Xia
Haiyang Zhang
Hui Wang
Mengda Jiang
Yan Tang
Yinwei Li
Jing Sun
Xuefei Song
Huifang Zhou
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03138-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Whole-orbit-based multiparametric assessment of disease activity of thyroid eye disease on Dixon MRI

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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