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International Ophthalmology

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01-12-2024 | Moxifloxacin | Original Paper

Comparison of preoperative prophylaxis with povidone–iodine (5%) and moxifloxacin (0.5%) versus povidone–iodine (5%) alone: a prospective study from India

Authors: Sanjana S. Sreedhar, A. R. Rajalakshmi, Swathi Nagarajan, Joshy M. Easow, Prabha Rajendran

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To compare the effect of povidone-iodine (PI) 5% and moxifloxacin 0.5% solutions versus PI 5% solution alone on the conjunctival bacterial flora.

Methodology

This is a comparative study in which the study population comprised adult patients scheduled for elective small incision cataract surgery. The eye to be operated (control eye) received topical moxifloxacin 0.5% drops 4 times, 1 day before surgery and 2 applications on the day of surgery. As placebo, the contralateral eye (study eye) received saline 0.90% drops as per the same schedule. Before surgery, on table, PI 5% was instilled in the conjunctival sac in both eyes. Conjunctival swabs were taken before initiation of therapy and 3 min after instillation of PI.

Results

Of the 96 pairs of eyes included in the study, conjunctival cultures before prophylaxis were similar between the two groups (p = 0.31), with 54 samples (56%) of the study group and 49 (51%) of the control group showing growth. With positive cultures reducing to 7 (14%) in the study group and 8 (16%) in the control group, both the prophylaxis methods appeared equally efficacious (p = 0.79). Both the groups showed a significant reduction in positive cultures following prophylaxis (p < 0.0001).

Conclusions

PI 5% alone as preoperative prophylaxis was as effective as its combination therapy with moxifloxacin 0.5% in the reduction in conjunctival bacterial colonization.

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Title: Comparison of preoperative prophylaxis with povidone–iodine (5%) and moxifloxacin (0.5%) versus povidone–iodine (5%) alone: a prospective study from India
Authors: Sanjana S. Sreedhar
A. R. Rajalakshmi
Swathi Nagarajan
Joshy M. Easow
Prabha Rajendran
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Moxifloxacin
Antibiotic
Cataract
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03025-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of preoperative prophylaxis with povidone–iodine (5%) and moxifloxacin (0.5%) versus povidone–iodine (5%) alone: a prospective study from India

Abstract

Purpose

Methodology

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methodology

Results

Conclusions

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