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Inflammation
Published in: Inflammation 5/2016

01-10-2016 | ORIGINAL ARTICLE

Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats

Authors: Vanessa Leal Scarabelot, Liciane Fernandes Medeiros, Carla de Oliveira, Lauren Naomi Spezia Adachi, Isabel Cristina de Macedo, Stefania Giotti Cioato, Joice S. de Freitas, Andressa de Souza, Alexandre Quevedo, Wolnei Caumo, Iraci Lucena da Silva Torres

Published in: Inflammation | Issue 5/2016

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Abstract

Melatonin is a neuroendocrine hormone that presents a wide range of physiological functions including regulating circadian rhythms and sleep, enhancing immune function, sleep improvement, and antioxidant effects. In addition, melatonin has received special attention in pain treatment since it is effective and presents few adverse effects. In this study, we evaluated the effect of acute dose of melatonin upon hyperalgesia induced by complete Freund’s adjuvant in a chronic orofacial pain model in Sprague–Dawley rats. Nociceptive behavior was assessed by facial Von Frey and the hot plate tests at baseline and thereafter 30, 60, and 120 min, 24 h, and 7 days after melatonin treatment. We demonstrated that acute melatonin administration alters mechanical and thermal hyperalgesia induced by an orofacial pain model (TMD), highlighting that the melatonin effect upon mechanical hyperalgesia remained until 7 days after its administration. Besides, we observed specific tissue profiles of neuroimmunomodulators linked to pain conditions and/or melatonin effect (brain-derived neurotrophic factor, nerve growth factor, and interleukins 6 and 10) in the brainstem levels, and its effects were state-dependent of the baseline of these animals.
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Metadata
Title
Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats
Authors
Vanessa Leal Scarabelot
Liciane Fernandes Medeiros
Carla de Oliveira
Lauren Naomi Spezia Adachi
Isabel Cristina de Macedo
Stefania Giotti Cioato
Joice S. de Freitas
Andressa de Souza
Alexandre Quevedo
Wolnei Caumo
Iraci Lucena da Silva Torres
Publication date
01-10-2016
Publisher
Springer US
Published in
Inflammation / Issue 5/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-016-0399-y

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