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Inflammation
Published in: Inflammation 2/2013

Open Access 01-04-2013

The Influence of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hematological Parameters During Experimentally Induced Pleuritis in Rats

Authors: Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Justyna Bazan, Katarzyna Dzierzba, Monika Całkosińska, Jacek Majda, Maciej Dobrzyński, Agnieszka Bronowicka-Szydełko

Published in: Inflammation | Issue 2/2013

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Abstract

Proper functioning of homeostatic mechanisms is characteristic for every healthy organism and enables adapting to environmental changes. These complicated systematic reactions can neutralize the harmful stress factors leading to various inflammatory reactions. The aim of this study was to determine dynamic changes in the inflammatory reaction after single 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration of 5 μg/kg body weight into rats with experimentally induced pleuritis. These changes were observed by monitoring the hematological blood parameters during inflammation. The obtained results proved that dioxins contribute to various changes in the character of the inflammatory response. TCDD administration before pleuritis initiation caused an increase of lymphocytes and significant decrease of the number of neutrophils during inflammation. The current study proved that administration of low TCDD dose (seven times lower than used in other studies) can cause thymus, spleen, or lymphatic gland atrophy. This finding indicates the toxic influence of small TCDD dose especially on the immune system.
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Metadata
Title
The Influence of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hematological Parameters During Experimentally Induced Pleuritis in Rats
Authors
Ireneusz Całkosiński
Joanna Rosińczuk-Tonderys
Justyna Bazan
Katarzyna Dzierzba
Monika Całkosińska
Jacek Majda
Maciej Dobrzyński
Agnieszka Bronowicka-Szydełko
Publication date
01-04-2013
Publisher
Springer US
Published in
Inflammation / Issue 2/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-012-9558-y

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