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Inflammation
Published in: Inflammation 3-4/2007

01-08-2007

Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction

Authors: Jun Guo, Guo-sheng Lin, Cui-yu Bao, Zhi-min Hu, Ming-yan Hu

Published in: Inflammation | Issue 3-4/2007

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Abstract

The aim of the present study was to investigate the role of anti-inflammation for MSCs transplantation in rat models of myocardial infarction. Rats with AMI induced by occlusion of the left coronary artery were randomized to MSCs transplantation group, MI group and sham operated group. The effects of MSCs transplantation on cardiac inflammation and left ventricular remodeling in non-infarcted zone were observed after 4 weeks of MI. We found that MSC transplantation (1) decreased protein production and gene expression of inflammation cytokines TNF-α, IL-1β and IL-6, (2) inhibited deposition of type I and III collagen, as well as gene and protein expression of MMP-1 and TIMP-1, (3) attenuated LV cavitary dilation and transmural infarct thinning, thus prevent myocardial remodeling after myocardial infarction, and (4) increased EF, FS, LVESP and dp/dtmax (P < 0.01), decreased LVDd, LVEDV, LVEDP (P < 0.05). Anti-inflammation role for MSCs transplantation might partly account for the cardiac protective effect in ischemic heart disease.
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Metadata
Title
Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction
Authors
Jun Guo
Guo-sheng Lin
Cui-yu Bao
Zhi-min Hu
Ming-yan Hu
Publication date
01-08-2007
Published in
Inflammation / Issue 3-4/2007
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-007-9025-3

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