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Published in: European Journal of Epidemiology 4/2024

09-04-2024 | COHORT PROFILE

A population-based cohort of drug exposures and adverse pregnancy outcomes in China (DEEP): rationale, design, and baseline characteristics

Authors: Jing Tan, Yiquan Xiong, Chunrong Liu, Peng Zhao, Pei Gao, Guowei Li, Jin Guo, Mingxi Li, Wanqiang Wei, Guanhua Yao, Yongyao Qian, Lishan Ye, Huanyang Qi, Hui Liu, Moliang Chen, Kang Zou, Lehana Thabane, Xin Sun

Published in: European Journal of Epidemiology | Issue 4/2024

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Abstract

The DEEP cohort is the first population-based cohort of pregnant population in China that longitudinally documented drug uses throughout the pregnancy life course and adverse pregnancy outcomes. The main goal of the study aims to monitor and evaluate the safety of drug use through the pregnancy life course in the Chinese setting. The DEEP cohort is developed primarily based on the population-based data platforms in Xiamen, a municipal city of 5 million population in southeast China. Based on these data platforms, we developed a pregnancy database that documented health care services and outcomes in the maternal and other departments. For identifying drug uses, we developed a drug prescription database using electronic healthcare records documented in the platforms across the primary, secondary and tertiary hospitals. By linking these two databases, we developed the DEEP cohort. All the pregnant women and their offspring in Xiamen are provided with health care and followed up according to standard protocols, and the primary adverse outcomes – congenital malformations – are collected using a standardized Case Report Form. From January 2013 to December 2021, the DEEP cohort included 564,740 pregnancies among 470,137 mothers, and documented 526,276 live births, 14,090 miscarriages and 6,058 fetal deaths/stillbirths and 25,723 continuing pregnancies. In total, 13,284,982 prescriptions were documented, in which 2,096 chemicals drugs, 163 biological products, 847 Chinese patent medicines and 655 herbal medicines were prescribed. The overall incidence rate of congenital malformations was 2.0% (10,444/526,276), while there were 25,526 (4.9%) preterm births and 25,605 (4.9%) live births with low birth weight.
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Metadata
Title
A population-based cohort of drug exposures and adverse pregnancy outcomes in China (DEEP): rationale, design, and baseline characteristics
Authors
Jing Tan
Yiquan Xiong
Chunrong Liu
Peng Zhao
Pei Gao
Guowei Li
Jin Guo
Mingxi Li
Wanqiang Wei
Guanhua Yao
Yongyao Qian
Lishan Ye
Huanyang Qi
Hui Liu
Moliang Chen
Kang Zou
Lehana Thabane
Xin Sun
Publication date
09-04-2024
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 4/2024
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-024-01124-6

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