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Published in: European Journal of Epidemiology 2/2017

01-02-2017 | NEW STUDY

The LIFE Child study: a population-based perinatal and pediatric cohort in Germany

Authors: Tanja Poulain, Ronny Baber, Mandy Vogel, Diana Pietzner, Toralf Kirsten, Anne Jurkutat, Andreas Hiemisch, Anja Hilbert, Jürgen Kratzsch, Joachim Thiery, Michael Fuchs, Christian Hirsch, Franziska G. Rauscher, Markus Loeffler, Antje Körner, Matthias Nüchter, Wieland Kiess, the LIFE Child study team

Published in: European Journal of Epidemiology | Issue 2/2017

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Abstract

The LIFE Child study is a large population-based longitudinal childhood cohort study conducted in the city of Leipzig, Germany. As a part of LIFE, a research project conducted at the Leipzig Research Center for Civilization Diseases, it aims to monitor healthy child development from birth to adulthood and to understand the development of lifestyle diseases such as obesity. The study consists of three interrelated cohorts; the birth cohort, the health cohort, and the obesity cohort. Depending on age and cohort, the comprehensive study program comprises different medical, psychological, and sociodemographic assessments as well as the collection of biological samples. Optimal data acquisition, process management, and data analysis are guaranteed by a professional team of physicians, certified study assistants, quality managers, scientists and statisticians. Due to the high popularity of the study, more than 3000 children have already participated until the end of 2015, and two-thirds of them participate continuously. The large quantity of acquired data allows LIFE Child to gain profound knowledge on the development of children growing up in the twenty-first century. This article reports the number of available and analyzable data and demonstrates the high relevance and potential of the study.
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Literature
3.
go back to reference Larsen PS, Kamper-Jørgensen M, Adamson A, Barros H, Bonde JP, Brescianini S, et al. Pregnancy and birth cohort resources in Europe: a large opportunity for aetiological child health research. Paediatr Perinat Epidemiol. 2013;27:393–414. doi:10.1111/ppe.12060.CrossRefPubMed Larsen PS, Kamper-Jørgensen M, Adamson A, Barros H, Bonde JP, Brescianini S, et al. Pregnancy and birth cohort resources in Europe: a large opportunity for aetiological child health research. Paediatr Perinat Epidemiol. 2013;27:393–414. doi:10.​1111/​ppe.​12060.CrossRefPubMed
5.
go back to reference Golding J, Pembrey M, Jones R, ALSPAC Study Team. ALSPAC—the avon longitudinal study of parents and children: study methodology. Paediatr Perinat Epidemiol. 2001;15:74–87.CrossRefPubMed Golding J, Pembrey M, Jones R, ALSPAC Study Team. ALSPAC—the avon longitudinal study of parents and children: study methodology. Paediatr Perinat Epidemiol. 2001;15:74–87.CrossRefPubMed
6.
go back to reference Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, et al. The Danish National Birth Cohort: its background, structure and aim. Scan J Public Health. 2001;29:300–7.CrossRef Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, et al. The Danish National Birth Cohort: its background, structure and aim. Scan J Public Health. 2001;29:300–7.CrossRef
7.
go back to reference Hölling H, Schlack R, Kamtsiuris P, Butschalowsky H, Schlaud M, Kurth BM. The KiGGS study. Nationwide representative longitudinal and cross-sectional study on the health of children and adolescents within the framework of health monitoring at the Robert Koch Institute. Bundesgesundheitsbl. 2012;55:836–42. doi:10.1007/s00103-012-1486-3.CrossRef Hölling H, Schlack R, Kamtsiuris P, Butschalowsky H, Schlaud M, Kurth BM. The KiGGS study. Nationwide representative longitudinal and cross-sectional study on the health of children and adolescents within the framework of health monitoring at the Robert Koch Institute. Bundesgesundheitsbl. 2012;55:836–42. doi:10.​1007/​s00103-012-1486-3.CrossRef
11.
go back to reference Winkler J, Stolzenberg H. Adjustierung des Sozialen-Schicht-Index für die Anwendung im Kinder-und Jugendgesundheitssurvey (KiGGS). Wismar: Hochsch. Fachbereich Wirtschaft; 2009. Winkler J, Stolzenberg H. Adjustierung des Sozialen-Schicht-Index für die Anwendung im Kinder-und Jugendgesundheitssurvey (KiGGS). Wismar: Hochsch. Fachbereich Wirtschaft; 2009.
12.
go back to reference Lawlor DA, Fraser A, Lindsay RS, Ness A, Dabelea D, Catalano P, et al. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia. 2010;53:89–97. doi:10.1007/s00125-009-1560-z.CrossRefPubMed Lawlor DA, Fraser A, Lindsay RS, Ness A, Dabelea D, Catalano P, et al. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia. 2010;53:89–97. doi:10.​1007/​s00125-009-1560-z.CrossRefPubMed
14.
go back to reference Kromeyer-Hauschild K, Wabitsch M, Kunze D, Gellert F, Geiß HC, Hesse V, et al. Perzentile für den Body-mass-Index für das Kindes-und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatss Kinderheilk. 2001;149:807–18.CrossRef Kromeyer-Hauschild K, Wabitsch M, Kunze D, Gellert F, Geiß HC, Hesse V, et al. Perzentile für den Body-mass-Index für das Kindes-und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatss Kinderheilk. 2001;149:807–18.CrossRef
15.
go back to reference Kromeyer-Hauschild K, Moss A, Wabitsch M. Referenzwerte für den Body-Mass-Index für Kinder, Jugendliche und Erwachsene in Deutschland. Anpassung der AGA-BMI-Referenz im Altersbereich von 15 bis 18 Jahren. Adipositas. 2015;9:123–7. Kromeyer-Hauschild K, Moss A, Wabitsch M. Referenzwerte für den Body-Mass-Index für Kinder, Jugendliche und Erwachsene in Deutschland. Anpassung der AGA-BMI-Referenz im Altersbereich von 15 bis 18 Jahren. Adipositas. 2015;9:123–7.
16.
go back to reference Freedman DS, Goodman A, Contreras OA, DasMahapatra P, Srinivasan SR, Berenson GS. Secular trends in BMI and blood pressure among children and adolescents: the Bogalusa Heart Study. Pediatrics. 2012;130:159–66. doi:10.1542/peds.2011-3302.CrossRef Freedman DS, Goodman A, Contreras OA, DasMahapatra P, Srinivasan SR, Berenson GS. Secular trends in BMI and blood pressure among children and adolescents: the Bogalusa Heart Study. Pediatrics. 2012;130:159–66. doi:10.​1542/​peds.​2011-3302.CrossRef
19.
go back to reference Kurth B, Schaffrath Rosario A. The prevalence of overweight and obese children and adolescents living in Germany: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsbl. 2007;50:736–43. doi:10.1007/s00103-007-0235-5.CrossRef Kurth B, Schaffrath Rosario A. The prevalence of overweight and obese children and adolescents living in Germany: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsbl. 2007;50:736–43. doi:10.​1007/​s00103-007-0235-5.CrossRef
22.
25.
go back to reference Asher MI, Montefort S, Björkstén B, Lai CKW, Strachan DP, Weiland SK, Williams H. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–43. doi:10.1016/S0140-6736(06)69283-0.CrossRefPubMed Asher MI, Montefort S, Björkstén B, Lai CKW, Strachan DP, Weiland SK, Williams H. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–43. doi:10.​1016/​S0140-6736(06)69283-0.CrossRefPubMed
26.
go back to reference Bekes K, John MT, Zyriax R, Schaller HG, Hirsch C. The German version of the Child Perceptions Questionnaire (CPQ-G11-14): translation process, reliability, and validity in the general population. Clin Oral Investig. 2012;16:165–71. doi:10.1007/s00784-010-0496-5.CrossRefPubMed Bekes K, John MT, Zyriax R, Schaller HG, Hirsch C. The German version of the Child Perceptions Questionnaire (CPQ-G11-14): translation process, reliability, and validity in the general population. Clin Oral Investig. 2012;16:165–71. doi:10.​1007/​s00784-010-0496-5.CrossRefPubMed
27.
go back to reference John MT, Patrick DL, Slade GD. The German version of the Oral Health Impact Profile: translation and psychometric properties. Eur J Oral Sci. 2002;110:425–33.CrossRefPubMed John MT, Patrick DL, Slade GD. The German version of the Oral Health Impact Profile: translation and psychometric properties. Eur J Oral Sci. 2002;110:425–33.CrossRefPubMed
28.
go back to reference Wagner MO, Bos K, Jekauc D, Karger C, Mewes N, Oberger J, et al. Cohort profile: the Motorik-Modul Longitudinal Study: physical fitness and physical activity as determinants of health development in German children and adolescents. Int J Epidemiol. 2014;43:1410–6. doi:10.1093/ije/dyt098.CrossRefPubMed Wagner MO, Bos K, Jekauc D, Karger C, Mewes N, Oberger J, et al. Cohort profile: the Motorik-Modul Longitudinal Study: physical fitness and physical activity as determinants of health development in German children and adolescents. Int J Epidemiol. 2014;43:1410–6. doi:10.​1093/​ije/​dyt098.CrossRefPubMed
31.
go back to reference Manning JT. The finger ratio. Sex, behaviour and disease revealed in the fingers. London: Faber and Faber; 2008. Manning JT. The finger ratio. Sex, behaviour and disease revealed in the fingers. London: Faber and Faber; 2008.
32.
go back to reference Herberth G, Hinz D, Bauer M, Röder S, Olek S, Hühn J, et al. Environmental exposure during pregnancy modulates fetal Treg development with consequences for the allergy risk of the child. J Reprod Immunol. 2012;94:54. doi:10.1016/j.jri.2012.03.336.CrossRef Herberth G, Hinz D, Bauer M, Röder S, Olek S, Hühn J, et al. Environmental exposure during pregnancy modulates fetal Treg development with consequences for the allergy risk of the child. J Reprod Immunol. 2012;94:54. doi:10.​1016/​j.​jri.​2012.​03.​336.CrossRef
33.
go back to reference Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, et al. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy. 2013;68:220–8. doi:10.1111/all.12081.CrossRefPubMed Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, et al. Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy. 2013;68:220–8. doi:10.​1111/​all.​12081.CrossRefPubMed
34.
go back to reference Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U. Examining the relationship between attention-deficit/hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry. 2012;21:39–49. doi:10.1007/s00787-011-0230-0.CrossRefPubMed Erhart M, Herpertz-Dahlmann B, Wille N, Sawitzky-Rose B, Holling H, Ravens-Sieberer U. Examining the relationship between attention-deficit/hyperactivity disorder and overweight in children and adolescents. Eur Child Adolesc Psychiatry. 2012;21:39–49. doi:10.​1007/​s00787-011-0230-0.CrossRefPubMed
35.
go back to reference Holtkamp K, Konrad K, Müller B, Heussen N, Herpertz S, Herpertz-Dahlmann B, Hebebrand J. Overweight and obesity in children with attention-deficit/hyperactivity disorder. Int J Obes Relat Metab Disord. 2004;28:685–9. doi:10.1038/sj.ijo.0802623.CrossRefPubMed Holtkamp K, Konrad K, Müller B, Heussen N, Herpertz S, Herpertz-Dahlmann B, Hebebrand J. Overweight and obesity in children with attention-deficit/hyperactivity disorder. Int J Obes Relat Metab Disord. 2004;28:685–9. doi:10.​1038/​sj.​ijo.​0802623.CrossRefPubMed
36.
go back to reference Bayley N. Bayley scales of infant development. 3rd ed. Frankfurt/Main: Pearson; 2006. Bayley N. Bayley scales of infant development. 3rd ed. Frankfurt/Main: Pearson; 2006.
37.
go back to reference Ravens-Sieberer U. The Kidscreen questionnaires: quality of life questionnaires for children and adolescents. Lengerich: Pabst Science Publ; 2006. Ravens-Sieberer U. The Kidscreen questionnaires: quality of life questionnaires for children and adolescents. Lengerich: Pabst Science Publ; 2006.
38.
go back to reference Goodman R. The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry. 1997;38:581–6.CrossRefPubMed Goodman R. The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry. 1997;38:581–6.CrossRefPubMed
40.
go back to reference Döpfner M, Lehmkuhl G. DISYPS-KJ: Diagnostik-System für psychische Störungen im Kindes-und Jugendalter nach ICD-10 und DSM-IV. 1st ed. Bern: Huber; 1998. Döpfner M, Lehmkuhl G. DISYPS-KJ: Diagnostik-System für psychische Störungen im Kindes-und Jugendalter nach ICD-10 und DSM-IV. 1st ed. Bern: Huber; 1998.
41.
42.
go back to reference Birch LL, Fisher JO, Grimm-Thomas K, Markey CN, Sawyer R, Johnson SL. Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness. Appetite. 2001;36:201–10. doi:10.1006/appe.2001.0398.CrossRefPubMed Birch LL, Fisher JO, Grimm-Thomas K, Markey CN, Sawyer R, Johnson SL. Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness. Appetite. 2001;36:201–10. doi:10.​1006/​appe.​2001.​0398.CrossRefPubMed
43.
go back to reference Hilbert A, Hartmann AS, Czaja J. Child Eating Disorder Examination-Questionnaire for Children: psychometric properties of the German version. Klin. Diagnostik u. Evaluation. 2008;1:447–64. Hilbert A, Hartmann AS, Czaja J. Child Eating Disorder Examination-Questionnaire for Children: psychometric properties of the German version. Klin. Diagnostik u. Evaluation. 2008;1:447–64.
44.
45.
go back to reference Schlarb AA, Schwerdtle B, Hautzinger M. Validation and psychometric properties of the German version of the Children’s Sleep Habits Questionnaire (CSHQ-DE). Somnologie. 2010;14:260–6. doi:10.1007/s11818-010-0495-4.CrossRef Schlarb AA, Schwerdtle B, Hautzinger M. Validation and psychometric properties of the German version of the Children’s Sleep Habits Questionnaire (CSHQ-DE). Somnologie. 2010;14:260–6. doi:10.​1007/​s11818-010-0495-4.CrossRef
46.
47.
48.
go back to reference Löwe B, Spitzer RL, Zipfel S, Herzog W. Gesundheitsfragebogen für Patienten (PHQ D). Komplettversion und Kurzform. Karlsruhe: Pfizer; 2002. Löwe B, Spitzer RL, Zipfel S, Herzog W. Gesundheitsfragebogen für Patienten (PHQ D). Komplettversion und Kurzform. Karlsruhe: Pfizer; 2002.
49.
go back to reference Neumann E, Rohmann E, Bierhoff H. Development and validation of scales for measuring avoidance and anxiety in romantic relationships: the Bochum Adult Attachment Questionnaire. Diagnostica. 2007;53:33–47. doi:10.1026/0012-1924.53.1.33.CrossRef Neumann E, Rohmann E, Bierhoff H. Development and validation of scales for measuring avoidance and anxiety in romantic relationships: the Bochum Adult Attachment Questionnaire. Diagnostica. 2007;53:33–47. doi:10.​1026/​0012-1924.​53.​1.​33.CrossRef
50.
go back to reference Wei M, Russell DW, Mallinckrodt B, Vogel DL. The Experiences in Close Relationship Scale (ECR)-short form: reliability, validity, and factor structure. J Personal Assess. 2007;88:187–204. doi:10.1080/00223890701268041.CrossRef Wei M, Russell DW, Mallinckrodt B, Vogel DL. The Experiences in Close Relationship Scale (ECR)-short form: reliability, validity, and factor structure. J Personal Assess. 2007;88:187–204. doi:10.​1080/​0022389070126804​1.CrossRef
52.
go back to reference Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131:485–91.CrossRefPubMed Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131:485–91.CrossRefPubMed
53.
go back to reference Ceglarek U, Müller P, Stach B, Bührdel P, Thiery J, Kiess W. Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria. Clini Chem Lab Med. 2002;40:693–7. doi:10.1515/CCLM.2002.119. Ceglarek U, Müller P, Stach B, Bührdel P, Thiery J, Kiess W. Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria. Clini Chem Lab Med. 2002;40:693–7. doi:10.​1515/​CCLM.​2002.​119.
56.
go back to reference Quante M, Bruckmann S, Wallborn T, Wolf N, Sergeyev E, Adler M, et al. Managing incidental findings and disclosure of results in a paediatric research cohort—the LIFE child study cohort. J Pediatr Endocrinol Metab. 2015;28:75–82. doi:10.1515/jpem-2014-0079.CrossRefPubMed Quante M, Bruckmann S, Wallborn T, Wolf N, Sergeyev E, Adler M, et al. Managing incidental findings and disclosure of results in a paediatric research cohort—the LIFE child study cohort. J Pediatr Endocrinol Metab. 2015;28:75–82. doi:10.​1515/​jpem-2014-0079.CrossRefPubMed
Metadata
Title
The LIFE Child study: a population-based perinatal and pediatric cohort in Germany
Authors
Tanja Poulain
Ronny Baber
Mandy Vogel
Diana Pietzner
Toralf Kirsten
Anne Jurkutat
Andreas Hiemisch
Anja Hilbert
Jürgen Kratzsch
Joachim Thiery
Michael Fuchs
Christian Hirsch
Franziska G. Rauscher
Markus Loeffler
Antje Körner
Matthias Nüchter
Wieland Kiess
the LIFE Child study team
Publication date
01-02-2017
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 2/2017
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-016-0216-9

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