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01-12-2019 | Gastric Cancer | SHORT REPORT

Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells

Authors: Jian-Ning Yao, Xue-Xiu Zhang, Yan-Zhen Zhang, Jia-Heng Li, Dong-Yao Zhao, Bing Gao, Hai-Ning Zhou, Shi-Lin Gao, Lian-Feng Zhang

Published in: Investigational New Drugs | Issue 6/2019

Summary

Background Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Novel anticancer drugs against gastric cancer are urgently needed. Methods Compound 10 was designed and synthesized via a molecular hybridization strategy based on the natural product formononetin. It was evaluated for their antiproliferative activity against three gastric cancer cell lines (SGC7901, MKN45 and MGC803). Results Derivative 10 displayed potently antiproliferative activity with an IC₅₀ value of 1.07 μM against SGC7901 cells. Derivative 10 could inhibit the growth and migration against gastric cancer SGC7901 cells through the Wnt/β-Catenin and AKT/mTOR pathways. From the in vivo expremints, it could effectively inhibited SGC7901 xenograft tumor growth in vivo without significant loss of the body weight. Conclusion Derivative 10 is an novel antitumor agent with potential for further clinical applications to treat gastric cancer.

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Title: Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells
Authors: Jian-Ning Yao
Xue-Xiu Zhang
Yan-Zhen Zhang
Jia-Heng Li
Dong-Yao Zhao
Bing Gao
Hai-Ning Zhou
Shi-Lin Gao
Lian-Feng Zhang
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Gastric Cancer
Coumarin
Gastric Cancer
Published in: Investigational New Drugs / Issue 6/2019
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-019-00767-7

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