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Digestive Diseases and Sciences

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01-08-2010 | Original Article

Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats

Authors: Miguel-Ángel Llamas, María-Ángeles Aller, Domingo Marquina, María-Paz Nava, Jaime Arias

Published in: Digestive Diseases and Sciences | Issue 8/2010

Abstract

Purpose

Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- (48 h) and long-term (1 month) postoperative evolution.

Results

At 48 h, ileal total aerobes bacteria (p < 0.001) and Lactobacillus decrease in sham-operated (SO) and portal hypertensive (PH) rats. At 1 month, ileal Enterococci and Streptococcus sp. show a statistically significant decrease in SO- and PH-rats. Lactobacillus decreases in the colon in SO- (p < 0.01) and in PH-rats (p < 0.001). At 1 month, colonic Enterococci decreases compared to control (p < 0.001) and SO-rats (p < 0.01). These intestinal microfloral changes are associated with bacterial translocation to mesenteric lymph nodes at 48 h (50%; p = 0.004) and 1 month (100%; p < 0.001) of postoperative evolution in PH-rats.

Conclusions

The enlargement of the stenosed portal tract related to triple partial portal vein ligation in the rat, since it increases the resistance to the portal blood flow, may be a key factor involved in one of the pathological consequences of portal hypertension, as is bacterial translocation to mesenteric lymph nodes.

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Title: Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats
Authors: Miguel-Ángel Llamas
María-Ángeles Aller
Domingo Marquina
María-Paz Nava
Jaime Arias
Publication date: 01-08-2010
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 8/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-009-1001-3

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