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01-03-2007 | Original ARTICLE

The Multiple Faces of Glucagon-Like Peptide-1—Obesity, Appetite, and Stress: What Is Next? A Review

Authors: Eldo E. Frezza, MD, MBA, FACS, Mitchell S. Wachtel, MD, Maurizio Chiriva-Internati, Phd

Published in: Digestive Diseases and Sciences | Issue 3/2007

Abstract

By itself, glucagon-like peptide-1(GLP-1) appears to be an excellent drug for appetite control and the treatment of obesity. Unfortunately, few enzymes, such as IV dipeptidyl peptidase and renal excretin, degrade and render GLP-1 inactive within minutes. A receptor agonist, exendin-4, with a longer biological half-life than GLP-1, has been tried. Subcutaneous injection of exendin-4 or continuous IV injection of GLP-1 warrants further research and investigation.

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Title: The Multiple Faces of Glucagon-Like Peptide-1—Obesity, Appetite, and Stress: What Is Next? A Review
Authors: Eldo E. Frezza, MD, MBA, FACS
Mitchell S. Wachtel, MD
Maurizio Chiriva-Internati, Phd
Publication date: 01-03-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Digestive Diseases and Sciences / Issue 3/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9096-2

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