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Published in:

01-10-2011

Oxidized LDL, LOX-1 and Atherosclerosis

Authors: Sona Mitra, Tanu Goyal, Jawahar L. Mehta

Published in: Cardiovascular Drugs and Therapy | Issue 5/2011

Abstract

An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. Ox-LDL plays a more important role in the genesis and progression of atherosclerosis than the native LDL. Ox-LDL leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. Ox-LDL is taken up by macrophages via scavenger receptors, such as SR-A1, SR-A2 and LOX-1. Lately, LOX-1, a type II membrane protein receptor of ox-LDL, has gained much importance in relation to effects of ox-LDL on endothelial biology. Endothelial cells primarily express LOX-1 as receptor for ox-LDL and ox-LDL has been shown to upregulate expression of LOX-1. In addition, ox-LDL promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. In this review we discuss the role of ox-LDL and LOX-1 in genesis and progression of atherosclerosis.

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Title: Oxidized LDL, LOX-1 and Atherosclerosis
Authors: Sona Mitra
Tanu Goyal
Jawahar L. Mehta
Publication date: 01-10-2011
Publisher: Springer US
Published in: Cardiovascular Drugs and Therapy / Issue 5/2011
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-011-6341-5

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LOX-1 and Obesity

LOX-1 Transcription

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page