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01-12-2011

Prospective Cohort Study of Gastrointestinal Complications and Vascular Diseases in Patients Taking Aspirin: Rationale and Design of the MAGIC Study

Authors: Hideki Origasa, Shinya Goto, Kazuyuki Shimada, Shinichiro Uchiyama, Yasushi Okada, Kentaro Sugano, Hideyuki Hiraishi, Naomi Uemura, Yasuo Ikeda, on behalf of the MAGIC Investigators

Published in: Cardiovascular Drugs and Therapy | Issue 6/2011

Abstract

Objective

Although aspirin has been widely prescribed for the prevention of cardiovascular events, its risk of gastrointestinal complications is of great concern. Despite expectations for such, few data are available on the prevalence or incidence of gastrointestinal complications in aspirin users in Japan. The Management of Aspirin-induced GastroIntestinal Complications (MAGIC) is the first attempt at collaboration among cardiologists, neurologists, and gastroenterologists to obtain such findings. We aim to share all about the MAGIC study.

Methods

The MAGIC is a prospective cohort study involving patients taking low-dose aspirin (81 mg to 325 mg per day) for longer than 1 month. Participants are recruited from multiple disease categories, including those with coronary artery disease, cerebrovascular disease, atrial fibrillation, and other cardiovascular conditions requiring antithrombotic therapy. Its duration of follow-up is 1 year. At baseline and 1 year follow-up, all participants will undergo endoscopic examination. The primary outcome is upper gastrointestinal complications, classified as erosions, ulcers, and bleeding. Secondary outcomes include LANZA score, non-fatal cardiovascular events, any bleeding, cancer, and death.

Results

1,533 participants were entered in the MAGIC cohort. By underlying disease, about 45% of them had coronary artery diseases, followed by cerebrovascular diseases (35%), atrial fibrillation (10%) and other cardiovascular diseases (10%).

Conclusions

The MAGIC study will yield important findings with regard to the prevalence and incidence of gastrointestinal complications and related risk factors for low-dose aspirin users. It may also report that use of anti-secretory agents such as proton pump inhibitors reduces the risk of such complications.

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Title: Prospective Cohort Study of Gastrointestinal Complications and Vascular Diseases in Patients Taking Aspirin: Rationale and Design of the MAGIC Study
Authors: Hideki Origasa
Shinya Goto
Kazuyuki Shimada
Shinichiro Uchiyama
Yasushi Okada
Kentaro Sugano
Hideyuki Hiraishi
Naomi Uemura
Yasuo Ikeda
on behalf of the MAGIC Investigators
Publication date: 01-12-2011
Publisher: Springer US
Published in: Cardiovascular Drugs and Therapy / Issue 6/2011
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-011-6328-2

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Prospective Cohort Study of Gastrointestinal Complications and Vascular Diseases in Patients Taking Aspirin: Rationale and Design of the MAGIC Study

Abstract

Objective

Methods

Results

Conclusions

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