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The International Journal of Cardiovascular Imaging

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01-08-2017 | Original Paper

The consistency of myocardial strain derived from heart deformation analysis

Authors: Eric J. Keller, Shanna Fang, Kai Lin, Benjamin H. Freed, Peter M. Smith, Bruce S. Spottiswoode, Rachel Davids, Maria Carr, Marie-Pierre Jolly, Michael Markl, James C. Carr, Jeremy D. Collins

Published in: The International Journal of Cardiovascular Imaging | Issue 8/2017

Abstract

The purpose of this study was to assess the consistency of semi-automated myocardial strain analysis by prototype software across field strengths, temporal resolutions, and examinations. 35 volunteers (48 ± 13 years; 20% women) and 25 patients (54 ± 12 years; 44% women) without significant cardiac dysfunction underwent cine cardiac magnetic resonance imaging (CMR) at 1.5 T with a temporal resolution of 39.2 msec. 34 subjects also underwent imaging at 3.0 T; 16 had repeat examinations within 14 days; and 9 underwent CMR with temporal resolutions of 12.5 and 39.2 msec on the same day. Prototype heart deformation analysis (HDA) software was used to retrospectively quantify strain from segmented balanced steady state free precession (bSSFP) cinegraphic images. Myocardial contours were automatically generated on short axis images and drawn at end-diastole by two independent reviewers on long-axis images. Contours were automatically propagated throughout the cardiac cycle. Global and regional peak systolic strain were compared across observers, field strengths, temporal resolutions, and examinations. Inter-observer agreement was excellent (ICC > 0.87, p < 0.01). Inter-examination variability was low, ranging from 1.7 (1.0–2.4)% to 2.5 (1.9–3.1)%, except for radial strain: 9.2 (7.6–10.5)%. Most global and regional strain values were not significantly different across field strengths and temporal resolutions (p > 0.05). Normal global peak systolic strain values with HDA were −25.0 (−24.0 to −26.1)% (LV circumferential), 60.5 (55.3 to 65.6)% (LV radial), −22.3 (−20.5 to − 24.0)% (LV longitudinal), and −26.0 (−23.8 to −28.2)% (RV longitudinal). HDA prototype software enabled efficient and consistent quantification of myocardial strain from conventional bSSFP cine CMR data, demonstrating clinical feasibility.

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Title: The consistency of myocardial strain derived from heart deformation analysis
Authors: Eric J. Keller
Shanna Fang
Kai Lin
Benjamin H. Freed
Peter M. Smith
Bruce S. Spottiswoode
Rachel Davids
Maria Carr
Marie-Pierre Jolly
Michael Markl
James C. Carr
Jeremy D. Collins
Publication date: 01-08-2017
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 8/2017
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-017-1090-6

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