Top

Published in:

01-08-2010 | Original paper

Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Authors: Dominique S. Michaud, Alina Vrieling, Li Jiao, Julie B. Mendelsohn, Emily Steplowski, Shannon M. Lynch, Jean Wactawski-Wende, Alan A. Arslan, H. Bas Bueno-de-Mesquita, Charles S. Fuchs, Myron Gross, Kathy Helzlsouer, Eric J. Jacobs, Andrea LaCroix, Gloria Petersen, Wei Zheng, Naomi Allen, Laufey Ammundadottir, Manuela M. Bergmann, Paolo Boffetta, Julie E. Buring, Federico Canzian, Stephen J. Chanock, Françoise Clavel-Chapelon, Sandra Clipp, Matthew S. Freiberg, J. Michael Gaziano, Edward L. Giovannucci, Susan Hankinson, Patricia Hartge, Robert N. Hoover, F. Allan Hubbell, David J. Hunter, Amy Hutchinson, Kevin Jacobs, Charles Kooperberg, Peter Kraft, Jonas Manjer, Carmen Navarro, Petra H. M. Peeters, Xiao-Ou Shu, Victoria Stevens, Gilles Thomas, Anne Tjønneland, Geoffrey S. Tobias, Dimitrios Trichopoulos, Rosario Tumino, Paolo Vineis, Jarmo Virtamo, Robert Wallace, Brian M. Wolpin, Kai Yu, Anne Zeleniuch-Jacquotte, Rachael Z. Stolzenberg-Solomon

Published in: Cancer Causes & Control | Issue 8/2010

Abstract

The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case–control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86–2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02–4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63–2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.

Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108CrossRefPubMed

Iodice S, Gandini S, Maisonneuve P, Lowenfels AB (2008) Tobacco and the risk of pancreatic cancer: a review and meta-analysis. Langenbecks Arch Surg 393(4):535–545CrossRefPubMed

Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A, Barzi F, Woodward M (2005) Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 92(11):2076–2083CrossRefPubMed

Giovannucci E, Michaud D (2007) The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 132(6):2208–2225CrossRefPubMed

Michaud DS (2004) Epidemiology of pancreatic cancer. Minerva Chir 59(2):99–111PubMed

Lowenfels AB, Maisonneuve P, Lankisch PG (1999) Chronic pancreatitis and other risk factors for pancreatic cancer. Gastroenterol Clin North Am 28(3):673–685 xCrossRefPubMed

World Cancer Research Fund, American Institute for Cancer Research (2008) Pancreas. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Intitute for Cancer Research, Washington, DC

Lin Y, Tamakoshi A, Kawamura T, Inaba Y, Kikuchi S, Motohashi Y, Kurosawa M, Ohno Y (2002) Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan collaborative cohort study for evaluation of cancer risk. Int J Cancer 99(5):742–746CrossRefPubMed

Isaksson B, Jonsson F, Pedersen NL, Larsson J, Feychting M, Permert J (2002) Lifestyle factors and pancreatic cancer risk: a cohort study from the Swedish Twin registry. Int J Cancer 98:480–482CrossRefPubMed

10.

Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS (2001) Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 10(5):429–437PubMed

11.

Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, Taylor PR, Virtamo J, Albanes D (2001) Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol 153(7):680–687CrossRefPubMed

12.

Coughlin SS, Calle EE, Patel AV, Thun MJ (2000) Predictors of pancreatic cancer mortality among a large cohort of United States adults. Cancer Causes Control 11(10):915–923CrossRefPubMed

13.

Villeneuve PJ, Johnson KC, Hanley AJ, Mao Y (2000) Alcohol, tobacco and coffee consumption and the risk of pancreatic cancer: results from the Canadian Enhanced Surveillance System case-control project. Canadian Cancer Registries Epidemiology Research Group. Eur J Cancer Prev 9(1):49–58

14.

Nilsen TI, Vatten LJ (2000) A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trondelag, Norway. Cancer Causes Control 11(7):645–652CrossRefPubMed

15.

Allen NE, Beral V, Casabonne D, Kan SW, Reeves GK, Brown A, Green J (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101(5):296–305CrossRefPubMed

16.

Zheng W, McLaughlin JK, Gridley G, Bjelke E, Schuman LM, Silverman DT, Wacholder S, Co-Chien HT, Blot WJ, Fraumeni JF Jr (1993) A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States). Cancer Causes Control 4(5):477–482CrossRefPubMed

17.

Harnack LJ, Anderson KE, Zheng W, Folsom AR, Sellers TA, Kushi LH (1997) Smoking, alcohol, coffee, and tea intake and incidence of cancer of the exocrine pancreas: the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev 6(12):1081–1086PubMed

18.

Heuch I, Kvale G, Jacobsen BK, Bjelke E (1983) Use of alcohol, tobacco and coffee, and risk of pancreatic cancer. Br J Cancer 48:637–643PubMed

19.

Silverman DT, Brown LM, Hoover RN, Schiffman M, Lillemoe KD, Schoenberg JB, Swanson GM, Hayes RB, Greenberg RS, Benichou J et al (1995) Alcohol and pancreatic cancer in blacks and whites in the United States. Cancer Res 55(21):4899–4905PubMed

20.

Partanen TJ, Vainio HU, Ojajarvi IA, Kauppinen TP (1997) Pancreas cancer, tobacco smoking and consumption of alcoholic beverages: a case-control study. Cancer Lett 116(1):27–32CrossRefPubMed

21.

Suzuki T, Matsuo K, Sawaki A, Mizuno N, Hiraki A, Kawase T, Watanabe M, Nakamura T, Yamao K, Tajima K, Tanaka H (2008) Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev 17(10):2742–2747CrossRefPubMed

22.

Jiao L, Silverman DT, Schairer C, Thiebaut AC, Hollenbeck AR, Leitzmann MF, Schatzkin A, Stolzenberg-Solomon RZ (2009) Alcohol use and risk of pancreatic cancer: the NIH-AARP diet and health study. Am J Epidemiol 169(9):1043–1051CrossRefPubMed

23.

Sigvardsson S, Hardell L, Przybeck TR, Cloninger R (1996) Increased cancer risk among Swedish female alcoholics. Epidemiology 7(2):140–143CrossRefPubMed

24.

Tonnesen H, Moller H, Andersen JR, Jensen E, Juel K (1994) Cancer morbidity in alcohol abusers. Br J Cancer 69(2):327–332PubMed

25.

Ye W, Lagergren J, Weiderpass E, Nyren O, Adami HO, Ekbom A (2002) Alcohol abuse and the risk of pancreatic cancer. Gut 51(2):236–239CrossRefPubMed

26.

Adami HO, McLaughlin JK, Hsing AW, Wolk A, Ekbom A, Holmberg L, Persson I (1992) Alcoholism and cancer risk: a population-based cohort study. Cancer Causes Control 3(5):419–425CrossRefPubMed

27.

Genkinger JM, Spiegelman D, Anderson KE, Bergkvist L, Bernstein L, van den Brandt PA, English DR, Freudenheim JL, Fuchs CS, Giles GG, Giovannucci E, Hankinson SE, Horn-Ross PL, Leitzmann M, Mannisto S, Marshall JR, McCullough ML, Miller AB, Reding DJ, Robien K, Rohan TE, Schatzkin A, Stevens VL, Stolzenberg-Solomon RZ, Verhage BA, Wolk A, Ziegler RG, Smith-Warner SA (2009) Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies. Cancer Epidemiol Biomarkers Prev 18(3):765–776CrossRefPubMed

28.

Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox JW Jr, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, Gonzalez CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 41(9):986–990CrossRefPubMed

29.

Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, Lacroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjonneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF Jr, Hoover RN, Hartge P, Chanock SJ (2010) A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42(3):224–228

30.

The ATBC Cancer Prevention Study Group (1994) The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann Epidemiol 4(1):1–10

31.

Huang HY, Alberg AJ, Norkus EP, Hoffman SC, Comstock GW, Helzlsouer KJ (2003) Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol 157(4):335–344CrossRefPubMed

32.

Calle EE, Rodriguez C, Jacobs EJ, Almon ML, Chao A, McCullough ML, Feigelson HS, Thun MJ (2002) The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer 94(9):2490–2501CrossRefPubMed

33.

Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C, Vignat J, Overvad K, Tjonneland A, Clavel-Chapelon F, Thiebaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, Gonzalez CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R (2002) European prospective investigation into cancer and nutrition (EPIC): study populations and data collection. Public Health Nutr 5(6B):1113–1124

34.

Kato I, Akhmedkhanov A, Koenig K, Toniolo PG, Shore RE, Riboli E (1997) Prospective study of diet and female colorectal cancer: the New York University Women’s Health Study. Nutr Cancer 28(3):276–281CrossRefPubMed

35.

Gohagan JK, Prorok PC, Hayes RB, Kramer BS (2000) The prostate, lung, colorectal and ovarian (PLCO) cancer screening trial of the national cancer institute: history, organization, and status. Control Clin Trials 21(6 Suppl):251S–272SCrossRefPubMed

36.

Cai H, Zheng W, Xiang YB, Xu WH, Yang G, Li H, Shu XO (2007) Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai men’s health study. Br J Nutr 98(5):1006–1013CrossRefPubMed

37.

Zheng W, Chow WH, Yang G, Jin F, Rothman N, Blair A, Li HL, Wen W, Ji BT, Li Q, Shu XO, Gao YT (2005) The Shanghai women’s health study: rationale, study design, and baseline characteristics. Am J Epidemiol 162(11):1123–1131CrossRefPubMed

38.

Design of the Women’s Health Initiative clinical trial and observational study (1998) The Women’s Health Initiative Study Group. Control Clin Trials 19(1):61–109

39.

Belanger CF, Hennekens CH, Rosner B, Speizer FE (1978) The nurses’ health study. Am J Nurs 78:1039–1040CrossRefPubMed

40.

Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, Stampfer MJ (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338:464–468CrossRefPubMed

41.

Buring JE (1992) The women’s health study research group. The women’s health study: summary of the study design. J Myocardiol Ischemia 4:27–29

42.

(1989) Physician’s health study: aspirin and primary prevention of coronary heart disease. N Engl J Med 321(26):1825–1828

43.

Kung HC, Hoyert DL, Xu JQ, Murphy SL (2008) National vital statistics reports. Deaths: final data for 2005. National Center for Health Statistics, Hyattsville

44.

Go VL, Gukovskaya A, Pandol SJ (2005) Alcohol and pancreatic cancer. Alcohol 35(3):205–211CrossRefPubMed

Title: Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)
Authors: Dominique S. Michaud
Alina Vrieling
Li Jiao
Julie B. Mendelsohn
Emily Steplowski
Shannon M. Lynch
Jean Wactawski-Wende
Alan A. Arslan
H. Bas Bueno-de-Mesquita
Charles S. Fuchs
Myron Gross
Kathy Helzlsouer
Eric J. Jacobs
Andrea LaCroix
Gloria Petersen
Wei Zheng
Naomi Allen
Laufey Ammundadottir
Manuela M. Bergmann
Paolo Boffetta
Julie E. Buring
Federico Canzian
Stephen J. Chanock
Françoise Clavel-Chapelon
Sandra Clipp
Matthew S. Freiberg
J. Michael Gaziano
Edward L. Giovannucci
Susan Hankinson
Patricia Hartge
Robert N. Hoover
F. Allan Hubbell
David J. Hunter
Amy Hutchinson
Kevin Jacobs
Charles Kooperberg
Peter Kraft
Jonas Manjer
Carmen Navarro
Petra H. M. Peeters
Xiao-Ou Shu
Victoria Stevens
Gilles Thomas
Anne Tjønneland
Geoffrey S. Tobias
Dimitrios Trichopoulos
Rosario Tumino
Paolo Vineis
Jarmo Virtamo
Robert Wallace
Brian M. Wolpin
Kai Yu
Anne Zeleniuch-Jacquotte
Rachael Z. Stolzenberg-Solomon
Publication date: 01-08-2010
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 8/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9548-z

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2010

Age-period-cohort analysis of cancers not related to tobacco, screening, or HIV: sex and race differences

Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case–control study in New Caledonia

Circulating cytokines and risk of B-cell non-Hodgkin lymphoma: a prospective study

Total antioxidant capacity intake and colorectal cancer risk in the Health Professionals Follow-up Study

Interleukin-22 genetic polymorphisms and risk of colon cancer

Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts

Keynote webinar | Spotlight on antibody–drug conjugates in cancer