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01-03-2007 | Original Paper

Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study

Authors: Kyung-Jae Lee, Manami Inoue, Tetsuya Otani, Motoki Iwasaki, Shizuka Sasazuki, Shoichiro Tsugane, JPHC Study Group

Published in: Cancer Causes & Control | Issue 2/2007

Abstract

Objective

To prospectively examine the association between physical activity and the risk of developing colorectal cancer in a large population-based cohort study of Japanese men and women, and to investigate whether the effects of physical activity on colorectal cancer risk differ by sex and subsite.

Methods

We analyzed data from a population-based cohort of 65,022 subjects. A total of 486 incident colorectal cancers (154 proximal colon, 166 distal colon and 149 rectal cancers) was identified during 6 years of follow-up.

Results

We observed a significant inverse association between physical activity and the risk of developing colorectal cancer, particularly colon cancer, among men. Relative to men in the lowest level of metabolic equivalent (MET) hours per day, those in the highest level had a RR of 0.69 (95% CI = 0.49–0.97). A significant decrease in risk of colorectal cancer was associated with increasing MET hours per day among men. This inverse association was essentially limited to colon cancer. A significant decrease in risk with increasing MET-hour score was observed predominantly for proximal colon cancer among men. In contrast, no significant decrease was seen among women.

Conclusion

These findings suggest that physical activity may prevent colon cancer among Japanese men.

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Title: Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study
Authors: Kyung-Jae Lee
Manami Inoue
Tetsuya Otani
Motoki Iwasaki
Shizuka Sasazuki
Shoichiro Tsugane
JPHC Study Group
Publication date: 01-03-2007
Publisher: Kluwer Academic Publishers
Published in: Cancer Causes & Control / Issue 2/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-006-0098-3

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Abstract

Objective

Methods

Results

Conclusion

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