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Cancer Causes & Control
Published in: Cancer Causes & Control 2/2007

01-03-2007 | Original Paper

Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer

Authors: Maureen A. Murtaugh, Karen Curtin, Carol Sweeney, Roger K. Wolff, Richard Holubkov, Bette J. Caan, Martha L. Slattery

Published in: Cancer Causes & Control | Issue 2/2007

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Abstract

Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone. Data were from participants in a case–control study conducted in Northern California and Utah (751 cases and 979 controls). We examined independent associations and interactions of folate, B vitamins, methionine, alcohol, and MTHFR polymorphisms (MTHFR C677T and A1298C) with rectal cancer. Dietary folate intake was associated with a reduction in rectal cancer OR 0.66, 95% CI 0.48–0.92 (>475 mcg day compared to < = 322 mcg) as was a combination of nutrient intakes contributing to higher methyl donor status (OR 0.79, 95% CI 0.66–0.95). Risk was reduced among women with the 677 TT genotype (OR 0.54, 95% CI 0.30–0.9), but not men (OR 1.11, 95% CI 0.70–1.76) and with the 1298 CC genotype in combined gender analysis (OR 0.67, 95% CI 0.46–0.98). These data are consistent with a protective effect of increasing dietary folate against rectal cancer and suggest a protective role of the MTHFR 677 TT genotype in women and 1298 CC in men and women. Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer.
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Metadata
Title
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer
Authors
Maureen A. Murtaugh
Karen Curtin
Carol Sweeney
Roger K. Wolff
Richard Holubkov
Bette J. Caan
Martha L. Slattery
Publication date
01-03-2007
Publisher
Kluwer Academic Publishers
Published in
Cancer Causes & Control / Issue 2/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-006-0099-2

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