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Breast Cancer Research and Treatment

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29-08-2023 | Mammography | Epidemiology

Diagnostic performance of screening mammography according to menstrual cycle among Asian women

Authors: Mi-ri Kwon, Yoosoo Chang, Inyoung Youn, Shin Ho Kook, Yoosun Cho, Boyoung Park, Seungho Ryu

Published in: Breast Cancer Research and Treatment | Issue 2/2023

Abstract

Purpose

To investigate the performance metrics of screening mammography according to menstrual cycle week in premenopausal Asian women.

Methods

This retrospective study included 69,556 premenopausal Asian women who underwent their first screening mammography between 2011 and 2019. The presence or absence of a breast cancer diagnosis within 12 months after the index screening mammography served as the reference standard, determined by linking the study data to the national cancer registry data. Menstrual cycles were calculated, and participants were assigned to groups according to weeks 1–4. The performance metrics included cancer detection rate (CDR), sensitivity, specificity, and positive predictive value (PPV), with comparisons across menstrual cycles.

Results

Among menstrual cycles, the lowest CDR at 4.7 per 1000 women (95% confidence interval [CI], 3.8–5.8 per 1000 women) was observed in week 4 (all P < 0.05). The highest sensitivity of 72.7% (95% CI, 61.4–82.3) was observed in week 1, although the results failed to reach statistical significance. The highest specificity of 80.4% (95% CI, 79.5–81.3%) was observed in week 1 (P = 0.01). The lowest PPV of 2.2% (95% CI, 1.8–2.7) was observed in week 4 (all P < 0.05).

Conclusion

Screening mammography tended to show a higher performance during week 1 and a lower performance during week 4 of the menstrual cycle among Asian women. These results emphasize the importance of timing recommendations that consider menstrual cycles to optimize the effectiveness of screening mammography for breast cancer detection.

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Title: Diagnostic performance of screening mammography according to menstrual cycle among Asian women
Authors: Mi-ri Kwon
Yoosoo Chang
Inyoung Youn
Shin Ho Kook
Yoosun Cho
Boyoung Park
Seungho Ryu
Publication date: 29-08-2023
Publisher: Springer US
Keywords: Mammography
Mammography
Breast Cancer
Breast Cancer
Published in: Breast Cancer Research and Treatment / Issue 2/2023
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-023-07087-8

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