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Published in: Breast Cancer Research and Treatment 3/2015

01-04-2015 | Epidemiology

Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium

Authors: Elisa V. Bandera, Urmila Chandran, Chi-Chen Hong, Melissa A. Troester, Traci N. Bethea, Lucile L. Adams-Campbell, Christopher A. Haiman, Song-Yi Park, Andrew F. Olshan, Christine B. Ambrosone, Julie R. Palmer, Lynn Rosenberg

Published in: Breast Cancer Research and Treatment | Issue 3/2015

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Abstract

African American (AA) women are more likely than white women to be obese and to be diagnosed with ER− and triple-negative (TN) breast cancer, but few studies have evaluated the impact of obesity and body fat distribution on breast cancer subtypes in AA women. We evaluated these associations in the AMBER Consortium by pooling data from four large studies. Cases were categorized according to hormone receptor status as ER+, ER−, and TN (ER−, PR−, and HER2−) based on pathology data. A total of 2104 ER+ cases, 1070 ER− cases (including 491 TN cases), and 12,060 controls were included. Odds ratios (OR) and 95 % confidence intervals (CI) were computed using logistic regression, taking into account breast cancer risk factors. In postmenopausal women, higher recent (most proximal value to diagnosis/index date) BMI was associated with increased risk of ER+ cancer (OR 1.31; 95 % CI 1.02–1.67 for BMI ≥35 vs. <25 kg/m2) and with decreased risk of TN tumors (OR 0.60; 95 % CI 0.39–0.93 for BMI ≥35 vs. <25). High young adult BMI was associated with decreased premenopausal ER+ cancer and all subtypes of postmenopausal cancer, and high recent waist-to-hip ratio with increased risk of premenopausal ER+ tumors (OR 1.35; 95 % CI 1.01–1.80) and all tumor subtypes combined in postmenopausal women (OR 1.26; 95 % CI 1.02–1.56). The impact of general and central obesity varies by menopausal status and hormone receptor subtype in AA women. Our findings imply different mechanisms for associations of adiposity with TN and ER+ breast cancers.
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Metadata
Title
Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium
Authors
Elisa V. Bandera
Urmila Chandran
Chi-Chen Hong
Melissa A. Troester
Traci N. Bethea
Lucile L. Adams-Campbell
Christopher A. Haiman
Song-Yi Park
Andrew F. Olshan
Christine B. Ambrosone
Julie R. Palmer
Lynn Rosenberg
Publication date
01-04-2015
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 3/2015
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-015-3353-z

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