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Published in: Breast Cancer Research and Treatment 1/2012

01-08-2012 | Letter To the Editor

Breast fat and breast cancer

Authors: Andreas Pettersson, Rulla M. Tamimi

Published in: Breast Cancer Research and Treatment | Issue 1/2012

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Excerpt

There is a well-established association between high mammographic density and risk of breast cancer. We recently observed, somewhat to our surprise, a strong inverse association between the nondense area on a mammogram and risk of breast cancer [1]. In this article, we briefly discuss this finding in the context of previous studies of mammographic density and breast cancer risk, as well as in context of prior findings of the association between excess body weight and breast cancer risk. We suggest that the notion that breast fat plays a protective role in breast carcinogenesis, at least during the premenopausal years, should be considered. …
Literature
1.
go back to reference Pettersson A, Hankinson SE, Willett WC, Lagiou P, Trichopoulos D, Tamimi RM (2011) Nondense mammographic area and risk of breast cancer. Breast Cancer Res 13(5):R100PubMedCrossRef Pettersson A, Hankinson SE, Willett WC, Lagiou P, Trichopoulos D, Tamimi RM (2011) Nondense mammographic area and risk of breast cancer. Breast Cancer Res 13(5):R100PubMedCrossRef
2.
go back to reference Byrne C, Schairer C, Wolfe J et al (1995) Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 87(21):1622–1629PubMedCrossRef Byrne C, Schairer C, Wolfe J et al (1995) Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst 87(21):1622–1629PubMedCrossRef
3.
go back to reference McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15(6):1159–1169PubMedCrossRef McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15(6):1159–1169PubMedCrossRef
4.
go back to reference Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526PubMedCrossRef Trichopoulos D, Lipman RD (1992) Mammary gland mass and breast cancer risk. Epidemiology 3(6):523–526PubMedCrossRef
5.
go back to reference Stuedal A, Ma H, Bernstein L, Pike MC, Ursin G (2008) Does breast size modify the association between mammographic density and breast cancer risk? Cancer Epidemiol Biomarkers Prev 17(3):621–627PubMedCrossRef Stuedal A, Ma H, Bernstein L, Pike MC, Ursin G (2008) Does breast size modify the association between mammographic density and breast cancer risk? Cancer Epidemiol Biomarkers Prev 17(3):621–627PubMedCrossRef
6.
go back to reference Lokate M, Peeters PH, Peelen LM, Haars G, Veldhuis WB, van Gils CH (2011) Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue. Breast Cancer Res 13(5):R103PubMedCrossRef Lokate M, Peeters PH, Peelen LM, Haars G, Veldhuis WB, van Gils CH (2011) Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue. Breast Cancer Res 13(5):R103PubMedCrossRef
7.
go back to reference Stone J, Ding J, Warren RM, Duffy SW, Hopper JL (2010) Using mammographic density to predict breast cancer risk: dense area or percentage dense area. Breast Cancer Res 12(6):R97 Stone J, Ding J, Warren RM, Duffy SW, Hopper JL (2010) Using mammographic density to predict breast cancer risk: dense area or percentage dense area. Breast Cancer Res 12(6):R97
8.
go back to reference Torres-Mejia G, De Stavola B, Allen DS et al (2005) Mammographic features and subsequent risk of breast cancer: a comparison of qualitative and quantitative evaluations in the Guernsey prospective studies. Cancer Epidemiol Biomarkers Prev 14(5):1052–1059PubMedCrossRef Torres-Mejia G, De Stavola B, Allen DS et al (2005) Mammographic features and subsequent risk of breast cancer: a comparison of qualitative and quantitative evaluations in the Guernsey prospective studies. Cancer Epidemiol Biomarkers Prev 14(5):1052–1059PubMedCrossRef
9.
go back to reference Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578PubMedCrossRef Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578PubMedCrossRef
10.
go back to reference Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226PubMedCrossRef Key TJ, Appleby PN, Reeves GK et al (2003) Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95(16):1218–1226PubMedCrossRef
11.
go back to reference Rose DP, Vona-Davis L (2010) Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66(1):33–38PubMedCrossRef Rose DP, Vona-Davis L (2010) Interaction between menopausal status and obesity in affecting breast cancer risk. Maturitas 66(1):33–38PubMedCrossRef
12.
go back to reference Boyd NF, Martin LJ, Sun L et al (2006) Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 15(11):2086–2092PubMedCrossRef Boyd NF, Martin LJ, Sun L et al (2006) Body size, mammographic density, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 15(11):2086–2092PubMedCrossRef
13.
go back to reference Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB (2011) Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol 174(8):909–918PubMedCrossRef Harris HR, Tamimi RM, Willett WC, Hankinson SE, Michels KB (2011) Body size across the life course, mammographic density, and risk of breast cancer. Am J Epidemiol 174(8):909–918PubMedCrossRef
14.
go back to reference Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15(3):279–290PubMedCrossRef Hovey RC, Aimo L (2010) Diverse and active roles for adipocytes during mammary gland growth and function. J Mammary Gland Biol Neoplasia 15(3):279–290PubMedCrossRef
15.
go back to reference Ching S, Kashinkunti S, Niehaus MD, Zinser GM (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J Cell Biochem 112(11):3393–3405PubMedCrossRef Ching S, Kashinkunti S, Niehaus MD, Zinser GM (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D and signal via vitamin D receptor, modulating mammary epithelial cell growth. J Cell Biochem 112(11):3393–3405PubMedCrossRef
16.
go back to reference Beer AE, Billingham RE (1978) Adipose tissue, a neglected factor in aetiology of breast cancer? Lancet 2(8084):296PubMedCrossRef Beer AE, Billingham RE (1978) Adipose tissue, a neglected factor in aetiology of breast cancer? Lancet 2(8084):296PubMedCrossRef
17.
go back to reference Levental KR, Yu H, Kass L et al (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139(5):891–906PubMedCrossRef Levental KR, Yu H, Kass L et al (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139(5):891–906PubMedCrossRef
18.
go back to reference Paszek MJ, Zahir N, Johnson KR et al (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241–254PubMedCrossRef Paszek MJ, Zahir N, Johnson KR et al (2005) Tensional homeostasis and the malignant phenotype. Cancer Cell 8(3):241–254PubMedCrossRef
19.
go back to reference Provenzano PP, Inman DR, Eliceiri KW, Keely PJ (2009) Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28(49):4326–4343PubMedCrossRef Provenzano PP, Inman DR, Eliceiri KW, Keely PJ (2009) Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene 28(49):4326–4343PubMedCrossRef
20.
go back to reference Ronnov-Jessen L, Bissell MJ (2009) Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med 15(1):5–13PubMedCrossRef Ronnov-Jessen L, Bissell MJ (2009) Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med 15(1):5–13PubMedCrossRef
21.
go back to reference Brower V (2010) Homing in on mechanisms linking breast density to breast cancer risk. J Natl Cancer Inst 102(12):843–845PubMedCrossRef Brower V (2010) Homing in on mechanisms linking breast density to breast cancer risk. J Natl Cancer Inst 102(12):843–845PubMedCrossRef
22.
go back to reference Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9(2):108–122PubMedCrossRef Butcher DT, Alliston T, Weaver VM (2009) A tense situation: forcing tumour progression. Nat Rev Cancer 9(2):108–122PubMedCrossRef
Metadata
Title
Breast fat and breast cancer
Authors
Andreas Pettersson
Rulla M. Tamimi
Publication date
01-08-2012
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2012
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-012-2186-2

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