Published in:
01-06-2010 | Brief Report
Severe prolonged cholestatic hepatitis caused by exemestane
Authors:
Ting Bao, John Fetting, Laura Mumford, Jane Zorzi, Karineh Shahverdi, Stacie Jeter, Frank Herlong, Vered Stearns, Linda Lee
Published in:
Breast Cancer Research and Treatment
|
Issue 3/2010
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Excerpt
Aromatase inhibitors (AIs) are used as first-line adjuvant hormonal therapy in postmenopausal women with hormone receptor-positive breast cancer, either as monotherapy or sequential therapy after tamoxifen [
1‐
6]. Unlike tamoxifen, the former gold standard adjuvant hormonal therapy, AIs cause musculoskeletal symptoms, osteoporosis, and bone fractures [
1‐
6]. Although AIs such as letrozole and anastrozole also cause liver enzyme elevation unrelated to liver metastasis in 3–5% patients,
1 , 2 severe hepatotoxicity has rarely been associated with AIs. We report a case of severe prolonged cholestatic hepatitis caused by exemestane. …