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01-09-2009 | Epidemiology

Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS)

Authors: Tsogzolmaa Dorjgochoo, Yu-Tang Gao, Wong-Ho Chow, Xiao-Ou Shu, Honglan Li, Gong Yang, Qiuyin Cai, Nathaniel Rothman, Hui Cai, Adrian A. Franke, Wei Zheng, Qi Dai

Published in: Breast Cancer Research and Treatment | Issue 2/2009

Abstract

Evidence from some previous studies suggests that lipophilic antioxidants, particularly carotenoids, may reduce the risk of breast cancer. We prospectively investigated the associations of plasma levels of tocopherols, retinol, carotenoids with the risk of developing breast cancer among Chinese women. We conducted a study of 365 incident breast cancer cases and 726 individually matched controls nested within a large cohort study of women aged 40–70 years at baseline. We observed no associations between breast cancer risk and any of the tocopherols, retinol, and most carotenoids. However, high levels of plasma lycopene other than trans, 5- and 7-cis or trans α-cryptoxanthin were inversely associated with the risk of developing breast cancer. Our results do not support an overall protective effect of lipophilic antioxidants on breast cancer risk. The few inverse associations observed for subtype of carotenoids may need to be confirmed in future studies.

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Title: Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS)
Authors: Tsogzolmaa Dorjgochoo
Yu-Tang Gao
Wong-Ho Chow
Xiao-Ou Shu
Honglan Li
Gong Yang
Qiuyin Cai
Nathaniel Rothman
Hui Cai
Adrian A. Franke
Wei Zheng
Qi Dai
Publication date: 01-09-2009
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 2/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-008-0270-4

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