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01-11-2008 | Epidemiology

TGFβ1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFβ1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy

Authors: Thangarajan Rajkumar, Mani Samson, Ranganathan Rama, Veluswami Sridevi, Urmila Mahji, Rajaraman Swaminathan, Nirmala K. Nancy

Published in: Breast Cancer Research and Treatment | Issue 1/2008

Abstract

The breast cancer incidence has been increasing in the south Indian women. A case (n = 250)–control (n = 500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP’s) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFβ1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer. In addition, the value of the SNP’s in predicting primary tumor’s pathologic response following neo-adjuvant chemo-radiotherapy was assessed. Genotyping was done using PCR (GSTM1, GSTT1), Taqman Allelic discrimination assay (GSTP1, c-erbB2) and PCR-CTPP (p53 and TGFβ1). None of the gene SNP’s studied were associated with a statistically significant increased risk for the breast cancer. However, combined analysis of the SNP’s showed that p53 (Arg/Arg and Arg/Pro) with TGFβ1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P = 0.01) and Multivariate (P = 0.003) analysis. There was no statistically significant association for the GST family members with the breast cancer risk. TGFβ1 (Pro/Pro) allele was found to predict complete pathologic response in the primary tumour following neo-adjuvant chemo-radiotherapy (OR = 6.53 and 10.53 in Univariate and Multivariate analysis respectively) (P = 0.004) and was independent of stage. This study suggests that SNP’s can help predict breast cancer risk in south Indian women and that TGFβ1 (Pro/Pro) allele is associated with a better pCR in the primary tumour.

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Title: TGFβ1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFβ1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy
Authors: Thangarajan Rajkumar
Mani Samson
Ranganathan Rama
Veluswami Sridevi
Urmila Mahji
Rajaraman Swaminathan
Nirmala K. Nancy
Publication date: 01-11-2008
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 1/2008
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9821-3

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