Top

Published in:

01-01-2008 | Epidemiology

Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study

Authors: Asha R. Kallianpur, Sang-Ah Lee, Yu-Tang Gao, Wei Lu, Ying Zheng, Zhi-Xian Ruan, Qi Dai, Kai Gu, Xiao-Ou Shu, Wei Zheng

Published in: Breast Cancer Research and Treatment | Issue 1/2008

Abstract

Background

Dietary fats and other constituents have been studied extensively in relation to breast cancer risk. Iron, an essential micronutrient with pro-oxidant properties, has received little attention, and specific fats may augment its toxicity. We investigated the effects of iron and fats from various food sources on the risk of breast cancer.

Methods

Participants in a population-based case–control study, 3,452 breast cancer cases, and 3,474 age-frequency-matched controls, completed in-person interviews, including a detailed food-frequency questionnaire. Plant- and animal-derived iron and fat intakes were derived from dietary intake data and food composition tables. Unconditional logistic regression models were used to study the independent and interactive effects of different forms of iron and fats on breast cancer risk.

Results

Animal-derived (largely heme) iron intake was positively associated with breast cancer risk (P _trend < 0.01; OR = 1.49 in the highest vs. lowest quartile, 95% confidence interval [CI] 1.25–1.78) after adjustment for known risk factors, antioxidant vitamin and isoflavone intake, and vitamin supplement use. The effect of animal-derived iron was similar in pre- and postmenopausal women. Intake of animal-derived fats was also associated with increased risk (adjusted OR = 1.34, 95% CI 1.14–1.58), particularly after menopause. A significant interaction between iron and fat from animal sources was observed (P < 0.01).

Conclusions

A high intake of animal-derived (heme) iron may be associated with an increased risk of primary breast cancer in Chinese women, and saturated and mono-unsaturated fats that are also derived from animal sources may augment this effect. Combined reductions in animal-derived iron and fat consumption have the potential to reduce breast cancer risk.

Kallianpur AR, Hall LD, Yadav M et al (2004) Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer. Cancer Epidemiol Biomarkers Prev 13:205–212PubMedCrossRef

Symons MC, Gutteridge JM (1998) Free radicals and iron: chemistry, biology, and medicine. Oxford University Press, London

Stevens RG, Graubard BI, Micozzi MS et al (1994) Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int J Cancer 56:364–369PubMedCrossRef

Kato I, Dnistrian AM, Schwartz M et al (1999) Iron intake, body iron stores, and colorectal cancer risk in women: a nested case–control study. Int J Cancer 80:693–698PubMedCrossRef

Chan AT, Ma J, Tranah GJ et al (2005) Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J Natl Cancer Inst 97:917–926PubMed

Kuvibidila SR, Gauther T, Rayford W (2004) Serum ferritin levels and transferrin saturation in men with prostate cancer. J Natl Med Assoc 96:641–649PubMed

Carpenter CE, Mahoney AW (1992) Contributions of heme and nonheme iron to human nutrition. Crit Rev Food Sci Nutr 31:333–367PubMedCrossRef

Hambraeus L (1999) Animal- and plant-food-based diets and iron status: benefits and costs. Proc Nutr Soc 58:235–242PubMedCrossRef

Kallianpur AR. Iron and oxidative injury—a commentary on "Fatty acid-mediated iron translocation: a synergistic mechanism of oxidative injury" by D. Yao et al (2005). Free Radic Biol Med 39:1305–1309

10.

Zheng W, Gustafson DR, Sinha R et al (1998) Well-done meat intake and the risk of breast cancer. J Natl Cancer Inst 90:1724–1729PubMedCrossRef

11.

Sinha R, Gustafson DR, Kulldorff M et al (2000) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk. J Natl Cancer Inst 92:1352–1354PubMedCrossRef

12.

Shannon J, Cook LS, Stanford JL (2003) Dietary intake and risk of postmenopausal breast cancer (United States). Cancer Causes Control 14:19–27PubMedCrossRef

13.

Gonzalez CA (2006) Nutrition and cancer: the current epidemiological evidence. Br J Nutr 96(suppl 1):S42–S45PubMed

14.

Boyd NF, Stone J, Vogt KN et al (2003) Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer 89:1672–1685PubMedCrossRef

15.

Yao D, Shi W, Gou Y et al (2005) Fatty acid-mediated intracellular iron translocation: a synergistic mechanism of oxidative injury. Free Radic Biol Med 39:1385–1398PubMedCrossRef

16.

Gao Y-T, Shu X-O, Dai Q et al (2000) Association of menstrual and reproductive factors with breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer 87:295–300PubMedCrossRef

17.

Shu X-O, Yang G, Jin F et al (2004) Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study. Eur J Clin Nutr 58:17–23PubMedCrossRef

18.

Shrubsole MJ, Gao Y-T, Cai Q et al (2004) MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 13:190–196PubMedCrossRef

19.

Boyapati SM, Shu X-O, Ruan Z-X et al (2005) Soyfood intake and breast cancer survival: a follow-up of the Shanghai Breast Cancer Study. Breast Canc Res Treat 92:11–17CrossRef

20.

Negri E, La Vecchia C, Franceschi S et al (1996) Intake of selected micronutrients and the risk or breast cancer. Int J Cancer 65:140–144PubMedCrossRef

21.

Adzersen KH, Jess P, Freivogel KW et al (2003) Raw and cooked vegetables, fruits, and selected micronutrients, and breast cancer risk: a case–control study in Germany. Nutr Cancer 46:131–137PubMedCrossRef

22.

Wang F, Elliott RL, Head JF (1999) Inhibitory effect of deferoxamine mesylate and low iron diet on the 13762NF rat mammary adenocarcinoma. Anticancer Res 19:445–450PubMed

23.

Stevens RG, Morris JE, Cordis GA et al (2003) Oxidative damage in colon and mammary tissue of the HFE knockout mouse. Free Radic Biol Med 34:1212–1216PubMedCrossRef

24.

Liehr JG, Jones JS (2001) Role of iron in estrogen-induced cancer. Curr Med Chem 8:839–849PubMed

25.

Wyllie S, Liehr JG (1998) Enhancement of estrogen-induced renal tumorigenesis in hamsters by dietary iron. Carcinogenesis 19:1285–1290PubMedCrossRef

26.

Nelson RL (2001) Iron and colorectal cancer risk: human studies. Nutr Rev 59:140–148PubMedCrossRef

27.

Lee D-H, Anderson KE, Harnack LJ et al (2004) Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. J Natl Cancer Inst 96:403–407PubMed

28.

Sesink AL, Termont DS, Kleibeuker JH (1999) Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res 59:5704–5709PubMed

29.

Oates PS, West AR (2006) Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility. World J Gastroenterol 12:4281–4295PubMed

30.

Cho E, Spiegelman D, Hunter DJ et al (2003) Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 95:1079–1085PubMedCrossRef

31.

Cho E, Chen WY, Hunter DJ et al (2006) Red meat intake and risk of breast cancer among premenopausal women. Arch Intern Med 166:2253–2259PubMedCrossRef

32.

Hunter DJ, Spiegelman D, Hans-Olov A et al (1996) Cohort studies of fat intake and the risk of breast cancer—a pooled analysis. N Engl J Med 334:356–361PubMedCrossRef

33.

Missmer SA, Smith-Warner SA, Spiegelman D et al (2002) Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol 31:78–85PubMedCrossRef

34.

Dai Q, Shu X-O, Jin F et al (2002) Consumption of animal foods, cooking methods, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 11:801–808PubMed

35.

Du S, Zhai F, Wang Y et al (2000) Current methods for estimating dietary iron bioavailability do not work in China. J Nutr 130:193–198PubMed

36.

Prentice RL, Caan B, Chlebowski RT et al (2006) Low-fat dietary pattern and risk of invasive breast cancer. The Women's Health Initiative Randomized Controlled Dietary Modification Trial. J Am Med Assoc 295:629–642CrossRef

37.

Barnard RJ, Gonzalez JH, Liva ME et al (2006) Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutr Cancer 55:28–34PubMedCrossRef

38.

Rock CL, Flatt SW, Thomson CA et al (2004) Effects of a high-fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer. J Clin Oncol 22:2379–2387PubMedCrossRef

39.

Kushi L, Giovannucci E (2002) Dietary fat and cancer. Am J Med 113(suppl 9B):63S–70SPubMedCrossRef

40.

Zacharski LR, Ornstein DL, Woloshin S, Schwartz LM (2000) Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data. Am Heart J 140:98–104PubMedCrossRef

41.

Sinha R, Cross A, Curtin J et al (2005) Development of a food frequency questionnaire module and databases for compounds in cooked and processed meats. Mol Nutr Food Res 49:648–655PubMedCrossRef

42.

Pierre F, Peiro G, Tache S (2006) New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid. Cancer Epidemiol Biomarkers Prev 15:2274–2279PubMedCrossRef

43.

Hanson LM, Engelman HM, Alekel DL et al (2006) Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am J Clin Nutr 84:774–780PubMed

44.

Hallberg L, Hulthen L (2000) Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 71:1147–1160PubMed

45.

Martinez-Torres C, Leets I, Taylor P et al (1986) Heme, ferritin and vegetable iron absorption in humans from meals denatured of heme iron during the cooking of beef. J Nutr 116:1720–1725PubMed

Title: Dietary animal-derived iron and fat intake and breast cancer risk in the Shanghai Breast Cancer Study
Authors: Asha R. Kallianpur
Sang-Ah Lee
Yu-Tang Gao
Wei Lu
Ying Zheng
Zhi-Xian Ruan
Qi Dai
Kai Gu
Xiao-Ou Shu
Wei Zheng
Publication date: 01-01-2008
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 1/2008
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9538-3

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2008

TGFβ2 and TβRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells

Intake of fruits, and vegetables in relation to breast cancer risk by hormone receptor status

Effects of polyamine depletion by α-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells

MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature

Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer

Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer

Keynote webinar | Spotlight on antibody–drug conjugates in cancer