Skip to main content
Top
Published in: Breast Cancer Research and Treatment 2/2007

01-10-2007 | Review

Paraneoplastic neurological syndromes and breast cancer. Regression of paraneoplastic neurological sensorimotor neuropathy in a patient with metastatic breast cancer treated with capecitabine: a case study and mini-review of the literature

Authors: Alessandro M. Minisini, Giada Pauletto, Paolo Bergonzi, Gianpiero Fasola

Published in: Breast Cancer Research and Treatment | Issue 2/2007

Login to get access

Abstract

Paraneoplastic neurological syndromes are a rare complication of breast cancer. Nevertheless, they may be clinically relevant leading to neurological impairment. Clinicians should be aware that these neurological disorders could even precede the diagnosis of breast cancer. Here we present the case of a female patient with advanced breast cancer who developed paraneoplastic sensorimotor neuropathy. Treatment with capecitabine lead to clinical amelioration. A review of the literature on the paraneoplastic neurological syndromes in breast cancer is also included.
Literature
1.
go back to reference Dalmau J, Gultekin HS, Posnes JB (1999) Paraneoplastic neurological syndromes: pathogenesis and physiopathology. Brain Pathol 9:261–273 Dalmau J, Gultekin HS, Posnes JB (1999) Paraneoplastic neurological syndromes: pathogenesis and physiopathology. Brain Pathol 9:261–273
3.
go back to reference Cao Y, Abbas J, Wu X, Dooley J et al (1999) Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature. Gynecol Oncol 75:178–183PubMedCrossRef Cao Y, Abbas J, Wu X, Dooley J et al (1999) Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature. Gynecol Oncol 75:178–183PubMedCrossRef
4.
go back to reference Peltola J, Hietaharju A, Rantala I et al (1998) A reversible neuronal antibody (anti-Tr) associated paraneoplastic cerebellar degeneration in Hodgkin’s disease. Acta Neurol Scand 98:360–363PubMedCrossRef Peltola J, Hietaharju A, Rantala I et al (1998) A reversible neuronal antibody (anti-Tr) associated paraneoplastic cerebellar degeneration in Hodgkin’s disease. Acta Neurol Scand 98:360–363PubMedCrossRef
5.
go back to reference Ohguro H, Yokoi Y, Ohguro I et al (2004) Clinical and immunologic aspects of cancer-associated retinopathy. Am J Ophthalmol 137:1117–1119PubMedCrossRef Ohguro H, Yokoi Y, Ohguro I et al (2004) Clinical and immunologic aspects of cancer-associated retinopathy. Am J Ophthalmol 137:1117–1119PubMedCrossRef
6.
go back to reference Newsom-Davis J (2004) Lambert-Eaton myasthenic syndrome. Rev Neurol (Paris) 160:177–180 Newsom-Davis J (2004) Lambert-Eaton myasthenic syndrome. Rev Neurol (Paris) 160:177–180
7.
go back to reference Tomimitsu H, Arimura K, Nagado et al (2004) Mechanism of action of voltage-gated K+ channel antibodies in acquired neuromyotonia. Ann Neurol 56:440–444PubMedCrossRef Tomimitsu H, Arimura K, Nagado et al (2004) Mechanism of action of voltage-gated K+ channel antibodies in acquired neuromyotonia. Ann Neurol 56:440–444PubMedCrossRef
8.
go back to reference Altaha R, Abraham J (2003) Paraneoplastic neurological syndrome associated with occult breast cancer: a case report and review of literature. Breast J 9:417–419PubMedCrossRef Altaha R, Abraham J (2003) Paraneoplastic neurological syndrome associated with occult breast cancer: a case report and review of literature. Breast J 9:417–419PubMedCrossRef
9.
go back to reference Rojas-Marcos I, Rousseau A, Keime-Guibert F et al (2003) Spectrum of paraneoplastic neurological disorders in women with breast and gynaecologic cancer. Medicine (Baltimore) 82:216–223CrossRef Rojas-Marcos I, Rousseau A, Keime-Guibert F et al (2003) Spectrum of paraneoplastic neurological disorders in women with breast and gynaecologic cancer. Medicine (Baltimore) 82:216–223CrossRef
10.
go back to reference Peterson K, Rosenblum MK, Kotanides H et al (1992) Paraneoplastic cerebellar degeneration. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 42:1931–1937PubMed Peterson K, Rosenblum MK, Kotanides H et al (1992) Paraneoplastic cerebellar degeneration. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 42:1931–1937PubMed
11.
go back to reference Gatti G, Sismek S, Kurne A et al (2003) Paraneoplastic neurological disorders in breast cancer. Breast 12:203–207PubMedCrossRef Gatti G, Sismek S, Kurne A et al (2003) Paraneoplastic neurological disorders in breast cancer. Breast 12:203–207PubMedCrossRef
12.
go back to reference Budde-Steffen C, Anderson NE, Rosenblum MK et al (1988) An antineuronal autoantibody in paraneoplastic opsoclonus. Ann Neurol 23:528PubMedCrossRef Budde-Steffen C, Anderson NE, Rosenblum MK et al (1988) An antineuronal autoantibody in paraneoplastic opsoclonus. Ann Neurol 23:528PubMedCrossRef
13.
go back to reference Poser JB (1995) Paraneoplastic syndromes. In:Poser JB (ed) Neurological complication of cancer. Contemporary neurology series 45, OUP, New York Poser JB (1995) Paraneoplastic syndromes. In:Poser JB (ed) Neurological complication of cancer. Contemporary neurology series 45, OUP, New York
14.
go back to reference Ohguro H, Nakazawa M (2002) Pathological roles of recoverin in cancer-associated retinopathy. Adv Exp Med Biol 514:109–124PubMed Ohguro H, Nakazawa M (2002) Pathological roles of recoverin in cancer-associated retinopathy. Adv Exp Med Biol 514:109–124PubMed
15.
go back to reference Chan C, O’Day J (2001) Melanoma-associated retinopathy: does autoimmunity prolong survival? Clin Experiment Ophthalmol 29:235–138PubMedCrossRef Chan C, O’Day J (2001) Melanoma-associated retinopathy: does autoimmunity prolong survival? Clin Experiment Ophthalmol 29:235–138PubMedCrossRef
16.
go back to reference Folli F, Piccolo G (2002) Stiff-man syndrome: pathogenetic, nosological, and therapeutic considerations. In:Vincent A, Martino G (ed) Antibodies in neurological disease, 1st edn. Springer-Verlag, Italia, Milano Folli F, Piccolo G (2002) Stiff-man syndrome: pathogenetic, nosological, and therapeutic considerations. In:Vincent A, Martino G (ed) Antibodies in neurological disease, 1st edn. Springer-Verlag, Italia, Milano
17.
go back to reference Pringle CE, Hudson AJ, Munoz DG et al (1992) Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 115:495–520PubMedCrossRef Pringle CE, Hudson AJ, Munoz DG et al (1992) Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 115:495–520PubMedCrossRef
18.
go back to reference Corcia P, Honnorat J, Guennoc AM et al (2000). Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome. Rev Neurol (Paris) 156:1020–1022 Corcia P, Honnorat J, Guennoc AM et al (2000). Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome. Rev Neurol (Paris) 156:1020–1022
19.
go back to reference Wakata N, Kurihara T, Saito E, Kinoshita M (2002) Polymyositis and dermatomyositis associated with malignancy: a 30 years retrospective study. Int J Dermatol 41:729–734PubMedCrossRef Wakata N, Kurihara T, Saito E, Kinoshita M (2002) Polymyositis and dermatomyositis associated with malignancy: a 30 years retrospective study. Int J Dermatol 41:729–734PubMedCrossRef
20.
go back to reference Levin MI, Mozaffar T, Al-Lozi MT et al (1998) Paraneoplastic necrotizing myopathy: clinical and pathological features. Neurology 50:764–767PubMed Levin MI, Mozaffar T, Al-Lozi MT et al (1998) Paraneoplastic necrotizing myopathy: clinical and pathological features. Neurology 50:764–767PubMed
21.
go back to reference Rudnicki SA, Dalmau J (2005) Paraneoplastic syndromes of the peripheral nerves. Curr Opin Neurol 18:598–603PubMedCrossRef Rudnicki SA, Dalmau J (2005) Paraneoplastic syndromes of the peripheral nerves. Curr Opin Neurol 18:598–603PubMedCrossRef
22.
go back to reference Camdessanche JP, Antoine JC, Honnorat J et al (2002) Paraneoplastic peripheral neuropathy associated with anti-Hu antibodies. A clinical and electrophysiological study of 20 patients. Brain 125:166–175 PubMedCrossRef Camdessanche JP, Antoine JC, Honnorat J et al (2002) Paraneoplastic peripheral neuropathy associated with anti-Hu antibodies. A clinical and electrophysiological study of 20 patients. Brain 125:166–175 PubMedCrossRef
23.
go back to reference Quarles RH, Weiss MD (1999) Autoantibodies associated with peripheral neuropathy. Muscle Nerve 22:800–822PubMedCrossRef Quarles RH, Weiss MD (1999) Autoantibodies associated with peripheral neuropathy. Muscle Nerve 22:800–822PubMedCrossRef
24.
go back to reference Graus F, Delattre JY, Antoine JC et al (2004) Recommended diagnostic criteria for paraneoplastic neurologicl syndromes. J Neuro Neurosurg Psychiatr 75:1135–1140CrossRef Graus F, Delattre JY, Antoine JC et al (2004) Recommended diagnostic criteria for paraneoplastic neurologicl syndromes. J Neuro Neurosurg Psychiatr 75:1135–1140CrossRef
Metadata
Title
Paraneoplastic neurological syndromes and breast cancer. Regression of paraneoplastic neurological sensorimotor neuropathy in a patient with metastatic breast cancer treated with capecitabine: a case study and mini-review of the literature
Authors
Alessandro M. Minisini
Giada Pauletto
Paolo Bergonzi
Gianpiero Fasola
Publication date
01-10-2007
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 2/2007
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-006-9444-0

Other articles of this Issue 2/2007

Breast Cancer Research and Treatment 2/2007 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine