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AIDS and Behavior
Published in: AIDS and Behavior 7/2022

28-01-2022 | Human Immunodeficiency Virus | Original Paper

Real-World User Experiences with a Digital Pill System to Measure PrEP Adherence: Perspectives from MSM with Substance Use

Authors: Peter R. Chai, Georgia R. Goodman, Olivia Bronzi, Gerard Gonzales, Alejandro Baez, Maria J. Bustamante, Jesse Najarro, Yassir Mohamed, Matthew C. Sullivan, Kenneth H. Mayer, Edward W. Boyer, Conall O’Cleirigh, Rochelle K. Rosen

Published in: AIDS and Behavior | Issue 7/2022

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Abstract

Once-daily oral pre-exposure prophylaxis (PrEP) is highly effective for preventing HIV transmission, but adherence can be challenging for men who have sex with men (MSM) who use substances. A novel method for directly measuring ingestion events is a digital pill system (DPS), which comprises an ingestible radiofrequency emitter that signals a wearable Reader device upon PrEP ingestion, relaying ingestion data to a wearable Reader device and then to a smartphone application. Qualitative interviews were conducted with 15 MSM with non-alcohol substance use following an open-label pilot demonstration trial involving use of the DPS to measure PrEP adherence for 90 days. The purpose of this qualitative investigation was to understand overall user experiences and potential barriers and facilitators to using the DPS to measure PrEP adherence among MSM. The DPS was largely perceived as acceptable, novel, and valuable, with most participants reporting that the system was easily integrated into their daily routines. Technological and design factors, especially related to the wearable Reader, impacted participants’ interest in using the technology long-term; several suggested improvements were discussed.
Trial Registration ClinicalTrials.gov: NCT03842436.
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Metadata
Title
Real-World User Experiences with a Digital Pill System to Measure PrEP Adherence: Perspectives from MSM with Substance Use
Authors
Peter R. Chai
Georgia R. Goodman
Olivia Bronzi
Gerard Gonzales
Alejandro Baez
Maria J. Bustamante
Jesse Najarro
Yassir Mohamed
Matthew C. Sullivan
Kenneth H. Mayer
Edward W. Boyer
Conall O’Cleirigh
Rochelle K. Rosen
Publication date
28-01-2022
Publisher
Springer US
Published in
AIDS and Behavior / Issue 7/2022
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-022-03594-9

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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