Skip to main content
Top
Published in: AIDS and Behavior 2/2021

01-02-2021 | Human Immunodeficiency Virus | Original Paper

The Effects of Perceived Stress and Cortisol Concentration on Antiretroviral Adherence When Mediated by Psychological Flexibility Among Southern Black Men Living with HIV

Authors: Robert L. Cooper, Lauren L. Brown, Mohammad Tabatabai, David W. Haas, Bryan E. Shepherd, Hector F. Myers, Ryan D. Edgerton, Castro Bonny, Julia A. Watson, Vladimir Berthaud

Published in: AIDS and Behavior | Issue 2/2021

Login to get access

Abstract

This pilot study investigates the correlation between psychological stress and antiretroviral therapy (ART) adherence and plasma HIV RNA (viral load) as mediated by psychological flexibility among Black men in the south. Data were collected from 48 HIV-positive, low income Black men. Results indicate a strong positive correlation between perceived stress and psychological inflexibility (adjusted for age and income rs = 0.67; p < 0.001), a negative correlation between psychological inflexibility and ART adherence (adjusted rs = − 0.32; p = 0.03), a negative correlation between perceived stress and ART adherence (adjusted rs = − 0.45; p = 0.006), and a negative correlation between ART adherence and viral load (adjusted rs = − 0.37; p = 0.04). Our findings suggest stress decreases adherence to ART and viral suppression among Black men living with HIV. However, psychological flexibility did not mediate the relationship between stress and treatment adherence. Hair cortisol concentrations were high (mean of 34.2 pg/mg), but uncorrelated with adherence.
Literature
1.
go back to reference US Centers for Disease Control and Prevention. HIV in the Southern United States. CDC Issue Brief. Atlanta: US Centers for Disease Control and Prevention; 2016. US Centers for Disease Control and Prevention. HIV in the Southern United States. CDC Issue Brief. Atlanta: US Centers for Disease Control and Prevention; 2016.
3.
go back to reference National HIV Strategy. National HIV/AIDS Strategy: Updated to 2020. Indicators-at-a-Glance. 2019. National HIV Strategy. National HIV/AIDS Strategy: Updated to 2020. Indicators-at-a-Glance. 2019.
4.
go back to reference Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016;375(9):830–9.CrossRef Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016;375(9):830–9.CrossRef
5.
go back to reference Keuroghlian AS, et al. Trauma, Dissociation, and antiretroviral adherence among persons living with HIV/AIDS. J Psychiatr Res. 2011;45:942–8.CrossRef Keuroghlian AS, et al. Trauma, Dissociation, and antiretroviral adherence among persons living with HIV/AIDS. J Psychiatr Res. 2011;45:942–8.CrossRef
6.
go back to reference Bogart LM, Wagner GJ, Galvan FH, Klein DJ. Longitudinal relationships between antiretroviral treatment adherence and discrimination due to HIV-serostatus, race, and sexual orientation among African-American men with HIV. Ann Behav Med. 2010;40(2):184–90.CrossRef Bogart LM, Wagner GJ, Galvan FH, Klein DJ. Longitudinal relationships between antiretroviral treatment adherence and discrimination due to HIV-serostatus, race, and sexual orientation among African-American men with HIV. Ann Behav Med. 2010;40(2):184–90.CrossRef
7.
go back to reference Thames AD, Moizel J, Panos SE, Patel SM, Byrd DA, Myers HF, et al. Differential predictors of medication adherence in HIV: findings from a sample of African American and Caucasian HIV-positive drug-using adults. AIDS Patient Care STDS. 2012;26(10):621–30.CrossRef Thames AD, Moizel J, Panos SE, Patel SM, Byrd DA, Myers HF, et al. Differential predictors of medication adherence in HIV: findings from a sample of African American and Caucasian HIV-positive drug-using adults. AIDS Patient Care STDS. 2012;26(10):621–30.CrossRef
8.
go back to reference Evans GW, Schamberg MA. Childhood poverty, chronic stress, and adult working memory. Proc Natl Acad Sci USA. 2009;106(16):6545–9.CrossRef Evans GW, Schamberg MA. Childhood poverty, chronic stress, and adult working memory. Proc Natl Acad Sci USA. 2009;106(16):6545–9.CrossRef
9.
go back to reference Weinstein TL, Xiaoming L. The relationship between stress and clinical outcomes for persons living with HIV/AIDS: a systematic review of the global literature. AIDS Care. 2016;28(2):160–9.CrossRef Weinstein TL, Xiaoming L. The relationship between stress and clinical outcomes for persons living with HIV/AIDS: a systematic review of the global literature. AIDS Care. 2016;28(2):160–9.CrossRef
10.
go back to reference Sun Y, Gao L, Kan Y, Shi B-X. The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systematic lupus erythematosus. Lupus. 2018;28(2):149–55.CrossRef Sun Y, Gao L, Kan Y, Shi B-X. The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systematic lupus erythematosus. Lupus. 2018;28(2):149–55.CrossRef
11.
go back to reference Anderou E, Alexopoulous EC, Lionis C, Varvogl L, Gnardellis C, Chrousos GP, Darviri C. Perceived stress scale: reliability and validity study in Greece. Int J Environ Red Public Health. 2011;8:3287–98.CrossRef Anderou E, Alexopoulous EC, Lionis C, Varvogl L, Gnardellis C, Chrousos GP, Darviri C. Perceived stress scale: reliability and validity study in Greece. Int J Environ Red Public Health. 2011;8:3287–98.CrossRef
12.
go back to reference Reis RS, Hino AAF, Anez CRR. Perceived stress scale: reliability and validity study in Brazil. J Health Psychol. 2010;15:107.CrossRef Reis RS, Hino AAF, Anez CRR. Perceived stress scale: reliability and validity study in Brazil. J Health Psychol. 2010;15:107.CrossRef
13.
go back to reference Gow R, Thomson R, Rieder M, Van Uum S, Koren G. An assessment of cortisol analysis in hair and its clinical applications. Forensic Sci Int. 2010;196(1–3):32–7.CrossRef Gow R, Thomson R, Rieder M, Van Uum S, Koren G. An assessment of cortisol analysis in hair and its clinical applications. Forensic Sci Int. 2010;196(1–3):32–7.CrossRef
14.
go back to reference Wosu A, Gelaye B, Valdimarsdóttir U, Kirschbaum C, Stalder T, Shields A, Williams M. Hair cortisol in relation to sociodemographic and lifestyle characteristics in a multiethnic US sample. Ann Epidemiol. 2015;25:90–5.CrossRef Wosu A, Gelaye B, Valdimarsdóttir U, Kirschbaum C, Stalder T, Shields A, Williams M. Hair cortisol in relation to sociodemographic and lifestyle characteristics in a multiethnic US sample. Ann Epidemiol. 2015;25:90–5.CrossRef
15.
go back to reference Spencer RL, Deak T. A users guide to the HPA axis. Physiol Behav. 2017;178:43–65.CrossRef Spencer RL, Deak T. A users guide to the HPA axis. Physiol Behav. 2017;178:43–65.CrossRef
16.
go back to reference Pochigaeva K, Druzhkova T, Yakovlev A, Onufriev MV. Hair cortisol as a marker of hypothalamic-pituitary-adrenal axis activity in female patients with major depressive disorder. Metab Brain Dis. 2017;32(2):577–83.CrossRef Pochigaeva K, Druzhkova T, Yakovlev A, Onufriev MV. Hair cortisol as a marker of hypothalamic-pituitary-adrenal axis activity in female patients with major depressive disorder. Metab Brain Dis. 2017;32(2):577–83.CrossRef
17.
go back to reference Rohleder N. Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems—2011 Curt Richter Award Winner. Psychoneuroendocrinology. 2012;37(3):307–16.CrossRef Rohleder N. Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems—2011 Curt Richter Award Winner. Psychoneuroendocrinology. 2012;37(3):307–16.CrossRef
18.
go back to reference Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130(4):601–30.CrossRef Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130(4):601–30.CrossRef
19.
go back to reference Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8(4):383–95.CrossRef Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci. 2006;8(4):383–95.CrossRef
20.
go back to reference DeHouwer J, Hughes S, Barnes-Holmes D. Associative learning as higher order cognition: learning in human and nonhuman animals from the perspective of propositional theories and relational frame theory. J Comp Psychol. 2016;130(3):215–25.CrossRef DeHouwer J, Hughes S, Barnes-Holmes D. Associative learning as higher order cognition: learning in human and nonhuman animals from the perspective of propositional theories and relational frame theory. J Comp Psychol. 2016;130(3):215–25.CrossRef
21.
go back to reference Hayes SC, Strosahl KD, Wilson KG. Acceptance and commitment therapy (2nd edition): the process and practice of mindful change. 2nd ed. New York: Guilford Press; 2012. Hayes SC, Strosahl KD, Wilson KG. Acceptance and commitment therapy (2nd edition): the process and practice of mindful change. 2nd ed. New York: Guilford Press; 2012.
22.
go back to reference Graham CD, Gouick J, Krahé C, Gillanders D. A systematic review of the use of Acceptance and Commitment Therapy (ACT) in chronic disease and long-term conditions. Clin Psychol Rev. 2016;46:46–58.CrossRef Graham CD, Gouick J, Krahé C, Gillanders D. A systematic review of the use of Acceptance and Commitment Therapy (ACT) in chronic disease and long-term conditions. Clin Psychol Rev. 2016;46:46–58.CrossRef
23.
go back to reference Moitra E, LaPlante A, Armstrong ML, Chan PA, Stein MD. Pilot randomized controlled trial of acceptance-based behavior therapy to promote HIV acceptance, HIV disclosure, and retention in medical care. AIDS Behav. 2017;21(9):2641–9.CrossRef Moitra E, LaPlante A, Armstrong ML, Chan PA, Stein MD. Pilot randomized controlled trial of acceptance-based behavior therapy to promote HIV acceptance, HIV disclosure, and retention in medical care. AIDS Behav. 2017;21(9):2641–9.CrossRef
24.
go back to reference Hayes SC, Luoma JB, Bond FW, Masuda A, Lillis J. Acceptance and commitment therapy: model, processes and outcomes. Behav Res Ther. 2006;44(1):1–25.CrossRef Hayes SC, Luoma JB, Bond FW, Masuda A, Lillis J. Acceptance and commitment therapy: model, processes and outcomes. Behav Res Ther. 2006;44(1):1–25.CrossRef
25.
go back to reference Ironson G, O’Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, Schneiderman N, Solomon G. Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med. 2004;67(6):1013–21.CrossRef Ironson G, O’Cleirigh C, Fletcher MA, Laurenceau JP, Balbin E, Klimas N, Schneiderman N, Solomon G. Psychosocial factors predict CD4 and viral load change in men and women with human immunodeficiency virus in the era of highly active antiretroviral treatment. Psychosom Med. 2004;67(6):1013–21.CrossRef
26.
go back to reference Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.CrossRef Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.CrossRef
27.
go back to reference Sternthal M, Slopen N, Williams DR. Racial disparities in health: how much does stress really matter? Du Bois Rev. 2011;8(1):95–113.CrossRef Sternthal M, Slopen N, Williams DR. Racial disparities in health: how much does stress really matter? Du Bois Rev. 2011;8(1):95–113.CrossRef
28.
go back to reference Wright Dom Naar-King S, Lam P, Templin T, Frey M. Stigma scale revised: reliability and validity of a brief measure of stigma for HIV + youth. J Adolesc Health. 2007;40(1):96–8.CrossRef Wright Dom Naar-King S, Lam P, Templin T, Frey M. Stigma scale revised: reliability and validity of a brief measure of stigma for HIV + youth. J Adolesc Health. 2007;40(1):96–8.CrossRef
29.
go back to reference Williams DR, Williams-Morris R. Racism and mental health: the African American experience. Ethn Health. 2000;5:243–68.CrossRef Williams DR, Williams-Morris R. Racism and mental health: the African American experience. Ethn Health. 2000;5:243–68.CrossRef
30.
go back to reference Gray M, Litz B, Hsu J, Lombardo T. Psychometric properties of the Life Events Checklist. Assessment. 2004;11:330–41.CrossRef Gray M, Litz B, Hsu J, Lombardo T. Psychometric properties of the Life Events Checklist. Assessment. 2004;11:330–41.CrossRef
31.
go back to reference Loussouran G, Lozano I, Panhard S, Collaudin C, El Rawadi C, Genain G. Diversity in human hair growth, diameter, colour, and shape. An in vivo study on young adults from 24 different ethnic groups observes in five continents. Eur J Dermatol. 2016;26(2):144–54.CrossRef Loussouran G, Lozano I, Panhard S, Collaudin C, El Rawadi C, Genain G. Diversity in human hair growth, diameter, colour, and shape. An in vivo study on young adults from 24 different ethnic groups observes in five continents. Eur J Dermatol. 2016;26(2):144–54.CrossRef
32.
go back to reference Loussouran G. African hair growth parameters. Br J Dermatol. 2001;145(2):294–7.CrossRef Loussouran G. African hair growth parameters. Br J Dermatol. 2001;145(2):294–7.CrossRef
33.
go back to reference Bond FW, Hayes SC, Baer RA, Carpenter KM, Guenole N, Orcutt HK, Waltz TZ, Zettle RD. Preliminary psychometric properties of the Acceptance and Action Questionniare - II: a revised measure of psychological flexibility and experiential avoidance. Behav Ther. 2011;42:676–88.CrossRef Bond FW, Hayes SC, Baer RA, Carpenter KM, Guenole N, Orcutt HK, Waltz TZ, Zettle RD. Preliminary psychometric properties of the Acceptance and Action Questionniare - II: a revised measure of psychological flexibility and experiential avoidance. Behav Ther. 2011;42:676–88.CrossRef
34.
go back to reference Kalichman SC, Amaral CM, Swetzes C, Jones M, Macy R, Kalichman MO, Cherry C. A simple single-item rating scale to measure medication adherence: further evidence for convergent validity. J Int Assoc Provid AIDS Care. 2009;8(6):367–74. Kalichman SC, Amaral CM, Swetzes C, Jones M, Macy R, Kalichman MO, Cherry C. A simple single-item rating scale to measure medication adherence: further evidence for convergent validity. J Int Assoc Provid AIDS Care. 2009;8(6):367–74.
35.
go back to reference Liu Q, Li C, Wanga V, Shepherd BE. Covariate-adjusted Spearman’s rank correlation with probability-scale residuals. Biometrics. 2018;74:595–605.CrossRef Liu Q, Li C, Wanga V, Shepherd BE. Covariate-adjusted Spearman’s rank correlation with probability-scale residuals. Biometrics. 2018;74:595–605.CrossRef
36.
go back to reference Vranceanu AM, Safren SA, Lu M, Coady WM, Skolnik PR, Rogers WH, Wilson IB. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in person with HIV. AIDS Patient Care and STDs. 2008;22(40):313–21.CrossRef Vranceanu AM, Safren SA, Lu M, Coady WM, Skolnik PR, Rogers WH, Wilson IB. The relationship of post-traumatic stress disorder and depression to antiretroviral medication adherence in person with HIV. AIDS Patient Care and STDs. 2008;22(40):313–21.CrossRef
37.
go back to reference Bottonari KA, Safren SA, McQuaid JR, Hsian CB, Roberts JE. A longitudinal investigation of the impact of life stress on HIV treatment adherence. J Behav Med. 2010;33(6):486–95.CrossRef Bottonari KA, Safren SA, McQuaid JR, Hsian CB, Roberts JE. A longitudinal investigation of the impact of life stress on HIV treatment adherence. J Behav Med. 2010;33(6):486–95.CrossRef
38.
go back to reference Nakimuli-Mpungu E, Misisi S, Wamala K, Okello J, Ndyanabangi S, Birungi J, et al. Recruitment and baseline characteristics of participants in the social, emotional, and economic empowerment through knowledge of group support psychotherapy study (SEEK-GSP): cluster randomized controlled trial. JMIR Res Protoc. 2019;8(1):11560.CrossRef Nakimuli-Mpungu E, Misisi S, Wamala K, Okello J, Ndyanabangi S, Birungi J, et al. Recruitment and baseline characteristics of participants in the social, emotional, and economic empowerment through knowledge of group support psychotherapy study (SEEK-GSP): cluster randomized controlled trial. JMIR Res Protoc. 2019;8(1):11560.CrossRef
39.
go back to reference Webel AR, Sattar A, Schreiner N, Kinley B, Moore SM, Salata RA. The impact of mental wellness on HIV self- management. J Asssoc Nurses AIDS Care. 2016;27(4):468–75.CrossRef Webel AR, Sattar A, Schreiner N, Kinley B, Moore SM, Salata RA. The impact of mental wellness on HIV self- management. J Asssoc Nurses AIDS Care. 2016;27(4):468–75.CrossRef
40.
go back to reference Wosu AC, Gelaye B, Valdimarsdottir U, Kirschbaum C, Stadler T, Shields AE, Williams MA. Hair cortisol in relation to socio-demographic and lifestyle characteristics in multi-ethnic US. Ann Epidemiol. 2015;25(2):90–5.CrossRef Wosu AC, Gelaye B, Valdimarsdottir U, Kirschbaum C, Stadler T, Shields AE, Williams MA. Hair cortisol in relation to socio-demographic and lifestyle characteristics in multi-ethnic US. Ann Epidemiol. 2015;25(2):90–5.CrossRef
Metadata
Title
The Effects of Perceived Stress and Cortisol Concentration on Antiretroviral Adherence When Mediated by Psychological Flexibility Among Southern Black Men Living with HIV
Authors
Robert L. Cooper
Lauren L. Brown
Mohammad Tabatabai
David W. Haas
Bryan E. Shepherd
Hector F. Myers
Ryan D. Edgerton
Castro Bonny
Julia A. Watson
Vladimir Berthaud
Publication date
01-02-2021
Publisher
Springer US
Published in
AIDS and Behavior / Issue 2/2021
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-020-03016-8

Other articles of this Issue 2/2021

AIDS and Behavior 2/2021 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine