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AIDS and Behavior
Published in: AIDS and Behavior 1/2013

01-01-2013 | Substantive Review

Predictors of Late Presentation for HIV Diagnosis: A Literature Review and Suggested Way Forward

Authors: Abraham Mukolo, Raquel Villegas, Muktar Aliyu, Kenneth A. Wallston

Published in: AIDS and Behavior | Issue 1/2013

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Abstract

Early commencement of antiretroviral treatment can be beneficial and economical in the long run. Despite global advances in access to care, a significant proportion of adults presenting at HIV/AIDS care facilities present with advanced HIV disease. Understanding factors associated with late presentation for HIV/AIDS services is critical to the development of effective programs and treatment strategies. Literature on factors associated with late presentation for an HIV diagnosis is reviewed. Highlighted is the current emphasis on socio-demographic factors, the limited exploration of psychosocial correlates, and inconsistencies in the definition of late presentation that make it difficult to compare findings across different studies. Perspectives based on experiences from resource limited settings are underreported. Greater exploration of psychosocial predictors of late HIV diagnosis is advocated for, to guide future intervention research and to inform public policy and practice targeted at ‘difficult to reach’ populations.
Literature
1.
Leombruni P, Fassino S, Lavagnino L, Orofino G, Morosini P, Picardi A. The role of anger in adherence to highly active antiretroviral treatment in patients infected with HIV. Psychother Psychosom. 2009;78:254–7.PubMedCrossRef
2.
When To Start Consortium, Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009;373:1352–63.
3.
Larson BA, Brennan A, McNamara L, Long L, Rosen S, Sanne I, et al. Lost opportunities to complete CD4+ lymphocyte testing among patients who tested positive for HIV in South Africa. Bull World Health Organ. 2010;88:675–80.PubMedCrossRef
4.
Rosen S, Fox M, Larson B. From HIV testing to treatment initiation: the missing link. In: 18th Conference on retroviruses and opportunistic infections (CROI), Boston, MA; 2011.
5.
Manga NM, Diop SA, Ndour CT, Dia NM, Mendy A, Coudec M, et al. Late diagnosis of HIV infection in the Fann, Dakar clinic of infectious diseases: testing circumstances, therapeutic course of patients, and determining factors. Med Mal Infect. 2009;39:95.PubMedCrossRef
6.
Harling G, Orrell C, Wood R. Healthcare utilization of patients accessing an African national treatment program. BMC Health Serv Res. 2007;7:80.PubMedCrossRef
7.
Sall L, Salamon E, Allgulander C, Owe-Larsson B. Psychiatric symptoms and disorders in HIV infected mine workers in South Africa. A retrospective descriptive study of acute first admissions. Afr J Psychiatry. 2009;12:206–12.
8.
Kigozi IM, Dobkin LM, Martin JN, Geng EH, Muyindike W, Emenyonu NI, et al. Late-disease stage at presentation to an HIV clinic in the era of free antiretroviral therapy in sub-Saharan Africa. J Acquir Immune Defic Syndr. 2009;52:280–9.PubMedCrossRef
9.
Girardi E, Sabin CA, Monforte AD. Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing. J Acquir Immune Defic Syndr. 2007;46(Suppl 1):S3–8.PubMedCrossRef
10.
Mussini C, Manzardo C, Johnson M, Monforte AdA, Uberti-Foppa C, Antinori A, et al. Patients presenting with AIDS in the HAART era: a collaborative cohort analysis. AIDS. 2008;22:2461–9.PubMedCrossRef
11.
Bonjour MA, Montagne M, Zambrano M, Molina G, Lippuner C, Wadskier FG, et al. Determinants of late disease-stage presentation at diagnosis of HIV infection in Venezuela: a case-case comparison. AIDS Res Ther. 2008;5:6.PubMedCrossRef
12.
Carrizosa CM, Blumberg EJ, Hovell MF, Martinez-Donate AP, Garcia-Gonzalez G, Lozada R, et al. Determinants and prevalence of late HIV testing in Tijuana, Mexico. AIDS Patient Care STDS. 2010;24:333–40.PubMedCrossRef
13.
Chadborn TR, Delpech VC, Sabin CA, Sinka K, Evans BG. The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000–2004). AIDS. 2006;20:2371–9.PubMedCrossRef
14.
Iliyasu Z, Abubakar IS, Kabir M, Aliyu MH. Knowledge of HIV/AIDS and attitude towards voluntary counseling and testing among adults. J Natl Med Assoc. 2006;98:1917–22.PubMed
15.
Hanna DB, Gupta LS, Jones LE, Thompson DM, Kellerman SE, Sackoff JE. AIDS-defining opportunistic illnesses in the HAART era in New York City. AIDS Care. 2007;19:264–72.PubMedCrossRef
16.
Lee JH, Kim GJ, Choi BS, Hong KJ, Heo MK, Kim SS, et al. Increasing late diagnosis in HIV infection in South Korea: 2000–2007. BMC Public Health. 2010;10:411.PubMedCrossRef
17.
Lemoh C, Guy R, Yohannes K, Lewis J, Street A, Biggs B, et al. Delayed diagnosis of HIV infection in Victoria 1994 to 2006. Sex Health. 2009;6:117–22.PubMedCrossRef
18.
Baker JV, Peng G, Rapkin J, Abrams DI, Silverberg MJ, MacArthur RD, et al. CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS. 2008;22:841–8.PubMedCrossRef
19.
Moore RD, Keruly JC. CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis. 2007;44:441–6.PubMedCrossRef
20.
Taiwo BO, Li X, Palella F, Jacobson LP, Margolick JB, Detels R, et al. Higher risk of AIDS or death in patients with lower CD4 cell counts after virally suppressive HAART. HIV Med. 2009;10:657–60.PubMedCrossRef
21.
Aiuti F, Mezzaroma I. Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART. AIDS Rev. 2006;8:88–97.PubMed
22.
Auld AF, Mbofana F, Shiraishi RW, Sanchez M, Alfredo C, Nelson LJ, et al. Four-year treatment outcomes of adult patients enrolled in Mozambique’s rapidly expanding antiretroviral therapy program. PLoS One. 2011;6:e18453.PubMedCrossRef
23.
Committee TUCHCS. Late diagnosis in the HAART era: proposed common definitions and associations with mortality. AIDS. 2010;24:723–7.
24.
Wolbers M, Bucher HC, Furrer H, Rickenbach M, Cavassini M, Weber R, et al. Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study. HIV Med. 2008;9:397–405.PubMedCrossRef
25.
Plitt SS, Mihalicz D, Singh AE, Jayaraman G, Houston S, Lee BE. Time to testing and accessing care among a population of newly diagnosed patients with HIV with a high proportion of Canadian Aboriginals, 1998–2003. AIDS Patient Care STDS. 2009;23:93–9.PubMedCrossRef
26.
Bamford LP, Ehrenkranz PD, Eberhart MG, Shpaner M, Brady KA. Factors associated with delayed entry into primary HIV medical care after HIV diagnosis. AIDS. 2010;24:928–30.PubMedCrossRef
27.
Reed JB, Hanson D, McNaghten AD, Bertolli J, Teshale E, Gardner L, et al. HIV testing factors associated with delayed entry into HIV medical care among HIV-infected persons from eighteen states, United States, 2000–2004. AIDS Patient Care STDS. 2009;23:765–73.PubMedCrossRef
28.
Krawczyk CS, Funkhouser E, Kilby JM, Kaslow RA, Bey AK, Vermund SH. Factors associated with delayed initiation of HIV medical care among infected persons attending a southern HIV/AIDS clinic. South Med J. 2006;99:472–81.PubMedCrossRef
29.
Angotti N, Bula A, Gaydosh L, Kimchi EZ, Thornton RL, Yeatman SE. Increasing the acceptability of HIV counseling and testing with three C’s: convenience, confidentiality and credibility. Soc Sci Med. 2009;68:2263–70.PubMedCrossRef
30.
Bateganya M, Abdulwadud OA, Kiene SM. WITHDRAWN: home-based HIV voluntary counseling and testing in developing countries. Cochrane Database Syst Rev. 2010;2:CD006493.
31.
Wringe A, Isingo R, Urassa M, Maiseli G, Manyalla R, Changalucha J, et al. Uptake of HIV voluntary counselling and testing services in rural Tanzania: implications for effective HIV prevention and equitable access to treatment. Trop Med Int Health. 2008;13:319–27.PubMedCrossRef
32.
Chiang HC, Yu KL, Yap SF, Goh KK, Mo MH, Yang TW, et al. Awareness of HIV/AIDS prevention and acceptance of HIV testing among residents in Likoma Island, northern Malawi. Trans R Soc Trop Med Hyg. 2009;103:885–91.PubMedCrossRef
33.
Ulett KB, Willig JH, Lin H-Y, Routman JS, Abroms S, Allison J, et al. The therapeutic implications of timely linkage and early retention in HIV care. AIDS Patient Care STDs. 2009;23:41–9.PubMedCrossRef
34.
Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLoS Med. 2007;4:e298.PubMedCrossRef
35.
Krawczyk CS, Funkhouser E, Kilby JM, Vermund SH. Delayed access to HIV diagnosis and care: special concerns for the Southern United States. AIDS Care. 2006;18(Suppl 1):S35–44.PubMedCrossRef
36.
Mayben JK, Kramer JR, Kallen MA, Franzini L, Lairson DR, Giordano TP. Predictors of delayed HIV diagnosis in a recently diagnosed cohort. AIDS Patient Care STDS. 2007;21:195–204.PubMedCrossRef
37.
Mugavero MJ, Castellano C, Edelman D, Hicks C. Late diagnosis of HIV infection: the role of age and sex. Am J Med. 2007;120:370–3.PubMedCrossRef
38.
Krentz HB, Auld MC, Gill MJ. The high cost of medical care for patients who present late (CD4 <200 cells/microL) with HIV infection. HIV Med. 2004;5:93–8.PubMedCrossRef
39.
Antinori A, Johnson M, Moreno S, Rockstroh JK, Yazdanpanah Y. Introduction to late presentation for HIV treatment in Europe. Antivir Ther. 2010;15(Suppl 1):1–2.PubMedCrossRef
40.
Burns FM, Imrie JY, Nazroo J, Johnson AM, Fenton KA. Why the(y) wait? key informant understandings of factors contributing to late presentation and poor utilization of HIV health and social care services by African migrants in Britain. AIDS Care. 2007;19:102–8.PubMedCrossRef
41.
Smith RD, Delpech VC, Brown AE, Rice BD. HIV transmission and high rates of late diagnoses among adults aged 50 years and over. AIDS. 2010;24:2109–15.PubMedCrossRef
42.
Yazdanpanah Y, Lange J, Gerstoft J, Cairns G. Earlier testing for HIV—how do we prevent late presentation? Antivir Ther. 2010;15(Suppl 1):17–24.PubMedCrossRef
43.
Kivela PS, Krol A, Salminen MO, Ristola MA. Determinants of late HIV diagnosis among different transmission groups in Finland from 1985 to 2005. HIV Med. 2010;11:360–7.PubMed
44.
Longo B, Pezzotti P, Boros S, Urciuoli R, Rezza G. Increasing proportion of late testers among AIDS cases in Italy, 1996–2002. AIDS Care. 2005;17:834–41.PubMedCrossRef
45.
Brinkhof MW, Dabis F, Myer L, Bangsberg DR, Boulle A, Nash D, et al. Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bull World Health Organ. 2008;86:559–67.PubMedCrossRef
46.
Burack JH, Barrett DC, Stall RD, Chesney MA, Ekstrand ML, Coates TJ. Depressive symptoms and CD4 lymphocyte decline among HIV-infected men. JAMA. 1993;270:2568–73.PubMedCrossRef
47.
Burns FM, Johnson AM, Nazroo J, Ainsworth J, Anderson J, Fakoya A, et al. Missed opportunities for earlier HIV diagnosis within primary and secondary healthcare settings in the UK. AIDS. 2008;22:115–22.PubMedCrossRef
48.
Yang B, Chan SK, Mohammad N, Meyer JA, Risser J, Chronister KJ, et al. Late HIV diagnosis in Houston/Harris County, Texas, 2000–2007. AIDS Care. 2010;22:766–74.PubMedCrossRef
49.
Shorter MM, Ostermann J, Crump JA, Tribble AC, Itemba DK, Mgonja A, et al. Characteristics of HIV voluntary counseling and testing clients before and during care and treatment scale-up in Moshi, Tanzania. J Acquir Immune Defic Syndr. 2009;52:648–54.PubMedCrossRef
50.
Anderson M, Elam G, Gerver S, Solarin I, Fenton K, Easterbrook P. “It took a piece of me”: initial responses to a positive HIV diagnosis by Caribbean people in the UK. AIDS Care. 2010;22:1493–8.PubMedCrossRef
51.
Beer L, Fagan JL, Valverde E, Bertolli J. Health-related beliefs and decisions about accessing HIV medical care among HIV-infected persons who are not receiving care. AIDS Patient Care STDs. 2009;23:785–92.PubMedCrossRef
52.
Chida Y, Vedhara K. Adverse psychosocial factors predict poorer prognosis in HIV disease: a meta-analytic review of prospective investigations. Brain Behav Immun. 2009;23:434–45.PubMedCrossRef
53.
Genberg BL, Hlavka Z, Konda KA, Maman S, Chariyalertsak S, Chingono A, et al. A comparison of HIV/AIDS-related stigma in four countries: negative attitudes and perceived acts of discrimination towards people living with HIV/AIDS. Soc Sci Med. 2009;68:2279–87.PubMedCrossRef
54.
Luseno WK, Wechsberg WM. Correlates of HIV testing among South African women with high sexual and substance-use risk behaviours. AIDS Care. 2009;21:178–84.PubMedCrossRef
55.
MacPhail C, Pettifor A, Moyo W, Rees H. Factors associated with HIV testing among sexually active South African youth aged 15–24 years. AIDS Care. 2009;21:456–67.PubMedCrossRef
56.
Olley BO, Gxamza F, Seedat S, Theron H, Taljaard J, Reid E, et al. Psychopathology and coping in recently diagnosed HIV/AIDS patients—the role of gender. S Afr Med J. 2003;93:928–31.PubMed
57.
Vajpayee M, Mojumdar K, Raina M, Mishra S, Sreenivas V. HIV voluntary counseling and testing: an experience from India. AIDS Care. 2009;21:826–33.PubMedCrossRef
58.
Mukolo A, Wallston KA. The relationship between positive psychological attributes and psychological well-being in persons with HIV/AIDS. AIDS Behav. 2011 [Epub ahead of print].
59.
Martikainen P, Bartley M, Lahelma E. Psychosocial determinants of health in social epidemiology. Int J Epidemiol. 2002;31:1091–3.PubMedCrossRef
60.
Link BG, Phelan JC. Conceptualizing stigma. Annu Rev Sociol. 2001;27:363–85.CrossRef
61.
Mukolo A, Heflinger CA, Wallston KA. The stigma of childhood mental disorders: a conceptual framework. J Am Acad Child Adolesc Psychiatry. 2010;49:92–103; quiz 198.
62.
Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52:793–800.PubMedCrossRef
63.
Wester WC, Bussmann H, Koethe J, Moffat C, Vermund S, Essex M, et al. Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Bostwana and future challenges. HIV Ther. 2009;3:501–26.PubMedCrossRef
64.
Rosinska M. Current trends in HIV/AIDS epidemiology in Poland, 1999–2004. Eurosurveillance. 2006;11:94–7.
65.
Adler A, Mounier-Jack S, Coker RJ. Late diagnosis of HIV in Europe: definitional and public health challenges. AIDS Care. 2009;21:284–93.PubMedCrossRef
66.
del Rio C. Report from the 15th retrovirus conference: continued problems with late HIV diagnosis and new problems with testing scale-up. AIDS Clin Care. 2008;20:26–7.PubMedCrossRef
67.
World Health Organization. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Geneva: WHO Press; 2007.
68.
Begovac J, Gedike K, Lukas D, Lepej SZ. Late presentation to care for HIV infection in Croatia and the effect of interventions during the Croatian Global Fund Project. AIDS Behav. 2008;12:S48–53.PubMedCrossRef
69.
Borghi V, Girardi E, Bellelli S, Angeletti C, Mussini C, Porter K, et al. Late presenters in an HIV surveillance system in Italy during the period 1992–2006. J Acquir Immune Defic Syndr. 2008;49:282–6.PubMedCrossRef
70.
Girardi E, Aloisi MS, Arici C, Pezzotti P, Serraino D, Balzano R, et al. Delayed presentation and late testing for HIV: demographic and behavioral risk factors in a multicenter study in Italy. J Acquir Immune Defic Syndr. 2004;36:951–9.PubMedCrossRef
71.
Balotta C, Bagnarelli P, Riva C, Valenza A, Antinori S, Colombo MC, et al. Comparable biological and molecular determinants in HIV type 1-infected long-term nonprogressors and recently infected individuals. AIDS Res Hum Retroviruses. 1997;13:337–41.PubMedCrossRef
72.
Marchetti G, Riva A, Cesari M, Bellistri GM, Gianelli E, Casabianca A, et al. HIV-infected long-term nonprogressors display a unique correlative pattern between the interleukin-7/interleukin-7 receptor circuit and T-cell homeostasis. HIV Med. 2009;10:422–31.PubMedCrossRef
73.
Castilla J, Sobrino P, De La Fuente L, Noguer I, Guerra L, Parras F. Late diagnosis of HIV infection in the era of highly active antiretroviral therapy: consequences for AIDS incidence. AIDS. 2002;16:1945–51.PubMedCrossRef
74.
Delpierre C, Dray-Spira R, Cuzin L, Marchou B, Massip P, Lang T, et al. Correlates of late HIV diagnosis: implications for testing policy. Int J STD AIDS. 2007;18:312–7.PubMedCrossRef
75.
Mojumdar K, Vajpayee M, Chauhan NK, Mendiratta S. Late presenters to HIV care and treatment, identification of associated risk factors in HIV-1 infected Indian population. BMC Public Health. 2010;10:416.PubMedCrossRef
76.
Chida Y, Steptoe A. Positive psychological well-being and mortality: a quantitative review of prospective observational studies. Psychosom Med. 2008;70:741–56.PubMedCrossRef
77.
Keiser O, Anastos K, Schechter M, Balestre E, Myer L, Boulle A, et al. Antiretroviral therapy in resource-limited settings to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Trop Med Int Health. 1996;13:870–9.
78.
Diero LO, Shaffer D, Kimaiyo S, Siika AM, Rotich JK, Smith FE, et al. Characteristics of HIV infected patients cared for at “academic model for the prevention and treatment of HIV/AIDS” clinics in western Kenya. East Afr Med J. 2006;83:424–33.PubMed
79.
Mugusi SF, Mwita JC, Francis JM, Aboud S, Bakari M, Aris EA, et al. Effect of improved access to antiretroviral therapy on clinical characteristics of patients enrolled in the HIV care and treatment clinic, at Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania. BMC Public Health. 2010;10:291.PubMedCrossRef
80.
Baratin D, Marceillac E, Trepo C, Cotte L, Peyramond D, Chidiac C, et al. Characteristics of patients diagnosed with AIDS shortly after first detection of HIV antibodies in Lyon University hospitals from 1985 to 2001. HIV Med. 2004;5:273–7.PubMedCrossRef
81.
Marcellin F, Abé C, Loubière S, Boyer S, Blanche J, Koulla-Shiro S, et al. Delayed first consultation after diagnosis of HIV infection in Cameroon. AIDS. 2009;23:1015–9.PubMedCrossRef
82.
Hocking JS, Rodger AJ, Rhodes DG, Crofts N. Late presentation of HIV infection associated with prolonged survival following AIDS diagnosis—characteristics of individuals. Int J STD AIDS. 2000;11:503–8.PubMedCrossRef
83.
Manavi K, McMillan A, Ogilvie M, Scott G. Heterosexual men and women with HIV test positive at a later stage of infection than homo- or bisexual men. Int J STD AIDS. 2004;15:811–4.PubMedCrossRef
84.
Nacher M, El Guedj M, Vaz T, Nasser V, Randrianjohany A, Alvarez F, et al. Risk factors for late HIV diagnosis in French Guiana. AIDS. 2005;19:727–9.PubMedCrossRef
85.
Manirankunda L, Loos J, Alou TA, Colebunders R, Nostlinger C. “It’s better not to know”: perceived barriers to HIV voluntary counseling and testing among sub-Saharan African migrants in Belgium. AIDS Educ Prev. 2009;21:582–93.PubMedCrossRef
86.
Wohl AR, Tejero J, Frye DM. Factors associated with late HIV testing for Latinos diagnosed with AIDS in Los Angeles. AIDS Care. 2009;21:1203–10.PubMedCrossRef
87.
Wong KH, Lee SS, Low KH, Wan WY. Temporal trend and factors associated with late HIV diagnosis in Hong Kong, a low HIV prevalence locality. AIDS Patient Care STDS. 2003;17:461–9.PubMedCrossRef
88.
Klein D, Hurley LB, Merrill D, Quesenberry CP Jr. Review of medical encounters in the 5 years before a diagnosis of HIV-1 infection: implications for early detection. J Acquir Immune Defic Syndr. 2003;32:143–52.PubMedCrossRef
89.
Bell C, Metsch LR, Vogenthaler N, Cardenas G, Rodriguez A, Locascio V, et al. Never in care: characteristics of HIV-infected crack cocaine users in 2 US cities who have never been to outpatient HIV care. J Acquir Immune Defic Syndr. 2010;54:376–80.PubMed
90.
Marsh KA, Reynolds GL, Rogala BE, Fisher DG, Napper LE. Who chooses a rapid test for HIV in Los Angeles County, California? Eval Health Prof. 2010;33:177–96.PubMedCrossRef
91.
Salovey P, Wegner DT. Communicating about health: message framing, persuasion and health behavior. In: Suls J, Wallston KA, editors. Social psychological foundations of health and illness. Calton: Blackwell; 2003. p. 54–81.CrossRef
92.
Baum A, Nesselhof SE. Psychological research and the prevention, etiology, and treatment of AIDS. Am Psychol. 1988;43:900–6.PubMedCrossRef
93.
Cleary PD, Van Devanter N, Rogers TF, Singer E, Shipton-Levy R, Steilen M, et al. Depressive symptoms in blood donors notified of HIV infection. Am J Public Health. 1993;83:534–9.PubMedCrossRef
94.
Owe-Larsson B, Sall L, Salamon E, Allgulander C. HIV infection and psychiatric illness. Afr J Psychiatry. 2009;12:115–28.
95.
Arendt G. Affective disorders in patients with HIV infection: impact of antiretroviral therapy. CNS Drugs. 2006;20:507–18.PubMedCrossRef
96.
Atkinson JH, Higgins JA, Vigil O, Dubrow R, Remien RH, Steward WT, et al. Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IV. AIDS Behav. 2009;13:1061–7.PubMedCrossRef
97.
Berger S, Schad T, von Wyl V, Ehlert U, Zellweger C, Furrer H, et al. Effects of cognitive behavioral stress management on HIV-1 RNA, CD4 cell counts and psychosocial parameters of HIV-infected persons. AIDS. 2008;22:767–75.PubMedCrossRef
98.
Coleman CL, Eller LS, Nokes KM, Bunch E, Reynolds NR, Corless IB, et al. Prayer as a complementary health strategy for managing HIV-related symptoms among ethnically diverse patients. Holist Nurs Pract. 2006;20:65–72.PubMed
99.
Eller LS, Corless I, Bunch EH, Kemppainen J, Holzemer W, Nokes K, et al. Self-care strategies for depressive symptoms in people with HIV disease. J Adv Nurs. 2005;51:119–30.PubMedCrossRef
100.
Gore-Felton C, Koopman C, Spiegel D, Vosvick M, Brondino M, Winningham A. Effects of quality of life and coping on depression among adults living with HIV/AIDS. J Health Psychol. 2006;11:711–29.PubMedCrossRef
101.
Ironson G, Balbin E, Stuetzle R, Fletcher M, O’Cleirigh C, Laurenceau J, et al. Dispositional optimism and the mechanisms by which it predicts slower disease progression in HIV: proactive behavior, avoidant coping, and depression. Int J Behav Med. 2005;12:86–97.PubMedCrossRef
102.
Kaharuza FM, Bunnell R, Moss S, Purcell DW, Bikaako-Kajura W, Wamai N, et al. Depression and CD4 cell count among persons with HIV infection in Uganda. AIDS Behav. 2006;10:S105–11.PubMedCrossRef
103.
Leserman J. Role of depression, stress, and trauma in HIV disease progression. Psychosom Med. 2008;70:539–45.PubMedCrossRef
104.
Leserman J, Barroso J, Pence BW, Salahuddin N, Harmon JL. Trauma, stressful life events and depression predict HIV-related fatigue. AIDS Care. 2008;20:1258–65.PubMedCrossRef
105.
Lyketsos CG, Hoover DR, Guccione M, Dew MA, Wesch JE, Bing EG, et al. Changes in depressive symptoms as AIDS develop. The Multicenter AIDS Cohort Study. Am J Psychiatry. 1996;153:1430–7.PubMed
106.
Pence BW, Miller WC, Whetten K, Eron JJ, Gaynes BN. Prevalence of DSM-IV-defined mood, anxiety, and substance use disorders in an HIV clinic in the Southeastern United States. J Acquir Immune Defic Syndr. 2006;42:298–306.PubMedCrossRef
107.
Parsons JT, Rosof E, Mustanski B. Medication adherence mediates the relationship between adherence self-efficacy and biological assessments of HIV health among those with alcohol use disorders. AIDS Behav. 2008;12:95–103.PubMedCrossRef
108.
Brydon L, Walker C, Wawrzyniak AJ, Chart H, Steptoe A. Dispositional optimism and stress-induced changes in immunity and negative mood. Brain Behav Immun. 2009;23:810–6.PubMedCrossRef
109.
Hammer SM, Eron JJ Jr, Reiss P, Schooley RT, Thompson MA, Walmsley S, et al. Antiretroviral treatment of adult HIV infection recommendations of the International AIDS Society-USA panel. JAMA. 2008;300:555–70.PubMedCrossRef
110.
Nyblade L, Stangl A, Weiss E, Ashburn K. Combating HIV stigma in health care settings: what works? J Int AIDS Soc. 2009;12:15.PubMedCrossRef
111.
Mahajan AP, Sayles JN, Patel VA, Remien RH, Sawires SR, Ortiz DJ, et al. Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward. AIDS. 2008;22(Suppl 2):S67–79.PubMedCrossRef
112.
Egger M, May M, Chene G, Phillips AN, Ledergerber B, Dabis F, et al. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002;360:119–29.PubMedCrossRef
113.
Ounga T, Okinyi M, Onyuro S. Knowledge of HIV survival on skin-piercing instruments among young adults in Nyanza Province, Kenya. Int J STD AIDS. 2009;20:119.PubMedCrossRef
114.
Heckman TG, Kochman A, Sikkema KJ, Kalichman SC, Masten J, Goodkin K. Late middle-aged and older men living with HIV/AIDS: race differences in coping, social support, and psychological distress. J Natl Med Assoc. 2000;92:436–44.PubMed
115.
Alonzo AA, Reynolds NR. Stigma, HIV and AIDS: an exploration and elaboration of a stigma trajectory. Soc Sci Med. 1995;41:303–15.PubMedCrossRef
116.
Kalichman SC, Simbayi LC. HIV testing attitudes, AIDS stigma, and voluntary HIV counselling and testing in a black township in Cape Town, South Africa. Sex Transm Infect. 2003;79:442–7.PubMedCrossRef
117.
Kang SK, Chasteen AL. The development and validation of the age-based rejection sensitivity questionnaire. Gerontologist. 2009;49:303–16.PubMedCrossRef
118.
Richman LS, Leary MR. Reactions to discrimination, stigmatization, ostracism, and other forms of interpersonal rejection: a multimotive model. Psychol Rev. 2009;116:365–83.CrossRef
119.
Edwards GL, Barber BL. The relationship between rejection sensitivity and compliant condom use. Arch Sex Behav. 2009;39:1381–8.PubMedCrossRef
120.
Corrigan PW, Watson AC, Barr L. The self-stigma of mental illness: implications for self-esteem and self-efficacy. J Soc Clin Psychol. 2006;25:875–84.CrossRef
121.
Link BG, Cullen FT, Struening EL, Shrout PE, Dohrenwend BP. A modified labeling theory approach to mental disorders: an empirical assessment. Am Sociol Rev. 1989;54:400–23.CrossRef
122.
Kemeny ME. An interdisciplinary research model to investigate psychosocial cofactors in disease: application to HIV-1 pathogenesis. Brain Behav Immun. 2003;17(Suppl 1):S62–72.PubMedCrossRef
123.
Martin SC, Wolters PL, Klaas PA, Perez L, Wood LV. Coping styles among families of children with HIV infection. AIDS Care. 2004;16:283–92.PubMedCrossRef
124.
Makoae LN, Greeff M, Phetlhu RD, Uys LR, Naidoo JR, Kohi TW, et al. Coping with HIV-related stigma in five African countries. J Assoc Nurses AIDS Care. 2008;19:137–46.PubMedCrossRef
125.
Aday LA, Andersen R. A Framework for the study of access to medical care. Health Serv Res. 1974;9:208–20.PubMed
126.
Pescosolido BA, Gardner CB, Lubell KM. How people get into mental health services: stories of choice, coercion and “muddling through” from “first-timers”. Soc Sci Med. 1998;46:275–86.PubMedCrossRef
127.
Jones DL, Ross D, Weiss SM, Bhat G, Chitalu N. Influence of partner participation on sexual risk behavior reduction among HIV-positive Zambian women. J Urban Health. 2005;82:iv92–100.PubMedCrossRef
128.
Wallston KA, Wallston BS. Health locus of control scales. In: Lefcourt H, editor. Research of the locus of control construct. New York: Academic Press; 1981. p. 189–243.
129.
Wallston KA, Maides S, Wallston BS. Health-related information seeking as a function of health-related locus of control and health value. J Res Pers. 1976;10:215–22.CrossRef
130.
Kilic BG, Sener S. Family functioning and psychosocial characteristics in children with attention deficit hyperactivity disorder with comorbid oppositional defiant disorder or conduct disorder. Türk Psikiyatri Dergisi (Turk J Psychiatry). 2005;16:21–8.
131.
Hoang T, Goetz MB, Yano EM, Rossman B, Anaya HD, Knapp H, et al. The impact of integrated HIV care on patient health outcomes. Med Care. 2009;47:560–7.PubMedCrossRef
132.
Pearson CR, Micek MA, Pfeiffer J, Montoya P, Matediane E, Jonasse T, et al. One year after ART initiation: psychosocial factors associated with stigma among HIV-positive Mozambicans. AIDS Behav. 2009;13:1189–96.PubMedCrossRef
133.
Maughan-Brown B. Stigma rises despite antiretroviral roll-out: a longitudinal analysis in South Africa. Soc Sci Med. 2010;70:368–74.PubMedCrossRef
134.
Sengupta S, Banks B, Jonas D, Miles MS, Smith GC. HIV interventions to reduce HIV/AIDS stigma: a systematic review. AIDS Behav. 2011;15:1075–87.PubMedCrossRef
135.
Aracena-Genao B, Navarro J, Lamadrid-Figueroa H, Forsythe S, Trejo-Valdivia B. Costs and benefits of HAART for patients with HIV in a public hospital in Mexico. AIDS. 2008;22(Suppl):S141–8.PubMedCrossRef
136.
Lawn SD, Myer L, Bekker LG, Wood R. CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa. BMC Infect Dis. 2006;6:59.PubMedCrossRef
137.
Kaufmann GR, Furrer H, Ledergerber B, Perrin L, Opravil M, Vernazza P, et al. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy. Clin Infect Dis. 2005;41:361–72.PubMedCrossRef
138.
McKinnon LR, Kimani M, Wachihi C, Nagelkerke NJ, Muriuki FK, Kariri A, et al. Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women. PLoS One. 2010;5:e11434.PubMedCrossRef
139.
Antinori A, Johnson M, Moreno S, Yazdanpanah Y, Rockstroh JK. Report of a European Working Group on late presentation with HIV infection: recommendations and regional variation. Antivir Ther. 2010;15(Suppl 1):31–5.PubMedCrossRef
140.
Johnson M, Sabin C, Girardi E. Definition and epidemiology of late presentation in Europe. Antivir Ther. 2010;15(Suppl 1):3–8.PubMedCrossRef
141.
Moreno S, Mocroft A, Monforte A. Medical and societal consequences of late presentation. Antivir Ther. 2010;15(Suppl 1):9–15.PubMedCrossRef
142.
Thanawuth N, Chongsuvivatwong V. Late HIV diagnosis and delay in CD4 count measurement among HIV-infected patients in Southern Thailand. AIDS Care. 2008;20:43–50.PubMedCrossRef
143.
Dodd PJ, Garnett GP, Hallett TB. Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS. 2010;24:729–35.PubMedCrossRef
144.
Tayler-Smith K, Zachariah R, Massaquoi M, Manzi M, Pasulani O, van den Akker T, et al. Unacceptable attrition among WHO stages 1 and 2 patients in a hospital-based setting in rural Malawi: can we retain such patients within the general health system? Trans R Soc Trop Med Hyg. 2010;104:313–9.PubMedCrossRef
145.
McDonald AM, Li Y, Dore GJ, Ree H, Kaldor JM. Late HIV presentation among AIDS cases in Australia, 1992–2001. Aust N Z J Public Health. 2003;27:608–13.PubMedCrossRef
146.
de Paoli MM, Manongi R, Klepp KI. Factors influencing acceptability of voluntary counselling and HIV-testing among pregnant women in Northern Tanzania. AIDS Care. 2004;16:411–25.PubMedCrossRef
147.
McLeroy KR, Bibeau D, Steckler A, Glanz K. An ecological perspective on health promotion programs. Health Educ Q. 1988;15:351–77.PubMedCrossRef
148.
Janz NK, Champion VL, Strecher VJ. The health belief model. In: Glanz K, Rimer BK, Lewis FM, editors. Health behavior and health education: theory, research, and practice. 3rd ed. San Francisco: Jossey-Bass; 2002. p. 45–66.
149.
Ajzen I. The theory of planned behavior. Organ Behav Hum Decis Process. 1991;50:179–211.CrossRef
150.
Rogers RW. Cognitive and physiological processes in fear appeals and attitude change: a revised theory of protection motivation. In: Cacioppo JT, Petty RE, editors. Social psychophysiology: a sourcebook. New York: The Guildford Press; 1983. p. 153–76.
151.
Grispen JE, Ronda G, Dinant GJ, de Vries NK, van der Weijden T. To test or not to test: a cross-sectional survey of the psychosocial determinants of self-testing for cholesterol, glucose, and HIV. BMC Public Health. 2011;11:112.PubMedCrossRef
Metadata
Title
Predictors of Late Presentation for HIV Diagnosis: A Literature Review and Suggested Way Forward
Authors
Abraham Mukolo
Raquel Villegas
Muktar Aliyu
Kenneth A. Wallston
Publication date
01-01-2013
Publisher
Springer US
Published in
AIDS and Behavior / Issue 1/2013
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-011-0097-6

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