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01-07-2014 | Clinical Investigation

Disturbed oxidant/antioxidant balance in aqueous humour of patients with exfoliation syndrome

Authors: Emrullah Beyazyıldız, Ali Bülent Çankaya, Özlem Beyazyıldız, Esra Ergan, Hüseyin Tuğrul Çelik, Pelin Yılmazbaş, Faruk Öztürk

Published in: Japanese Journal of Ophthalmology | Issue 4/2014

Abstract

Purpose

To establish the total oxidant status (TOS), total antioxidant capacity (TAC) and oxidative stress index (OSI) of the aqueous humour in patients presenting exfoliation syndrome (EXS) without glaucoma.

Methods

The TOS, TAC and OSI of the aqueous humour of patients with EXS (group 1, n = 17) and patients without EXS (group 2, n = 25) who underwent cataract surgery were evaluated. Samples were measured spectrophotometrically using a colourimetric method. The Mann–Whitney U, independent-samples t tests, Pearson correlation and analysis of covariance tests were used in the statistical analyses.

Results

The mean TOS in group 1 and 2 patients was 57.6 ± 32.4 and 30.4 ± 22.6 mmol/L, respectively, which is a statistically significant difference (p = 0.001). The mean TAC level in group 1 and 2 patients was 2.3 ± 0.7 and 2.5 ± 0.7 mmol/L, respectively, and although TAC was decreased in group 1 relative to group 2, the difference was not statistically significant (p = 0.55). The mean OSI in group 1 and 2 patients was 27.4 ± 17.1 and 12.5 ± 8.3 mmol/L, respectively, with the mean OSI level statistically higher in group 1 (p = 0.03).

Conclusion

Our findings provide evidence that the aqueous humour of EXS patients is characterised by increased oxidative stress and a disturbed oxidant/antioxidant balance. The increased oxidative stress and decreased levels of antioxidants in ocular fluids of EXS patients may play a significant role in the pathogenesis and complications of EXS.

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Title: Disturbed oxidant/antioxidant balance in aqueous humour of patients with exfoliation syndrome
Authors: Emrullah Beyazyıldız
Ali Bülent Çankaya
Özlem Beyazyıldız
Esra Ergan
Hüseyin Tuğrul Çelik
Pelin Yılmazbaş
Faruk Öztürk
Publication date: 01-07-2014
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 4/2014
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-014-0325-5

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Springer Medicine

Disturbed oxidant/antioxidant balance in aqueous humour of patients with exfoliation syndrome

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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